Statin Drugs Are Associated With Response to Immune Checkpoint Blockade in Recurrent/Metastatic Head and Neck Cancer

Statin Drugs Are Associated With Response to Immune Checkpoint Blockade in Recurrent/Metastatic Head and Neck Cancer

ABSTRACT Background Statin drugs, frequently used to treat hyperlipidemia, are associated with improved survival outcomes in multiple solid tumor types, including head and neck squamous cell carcinoma (HNSCC). Preclinical studies suggest that manipulation of cholesterol with statins and other agents...

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Bibliographic Details
Main Authors: Tyler J. Kristoff, Sean Evans, Pranay Nayi, Marin Abousaud, Subir Goyal, Yuan Liu, Dong Shin, Conor E. Steuer, Nabil F. Saba, Nicole C. Schmitt
Format: Article
Language:English
Published: Wiley 2025-03-01
Series:Cancer Medicine
Subjects:
head and neck cancer
immune checkpoint blockade
immunotherapy
PD‐1
PD‐L1
squamous cell carcinoma
Online Access:https://doi.org/10.1002/cam4.70718
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