FHL2 deteriorates IL-1β induced inflammation, apoptosis, and extracellular matrix degradation in chondrocyte-like ATDC5 cells by mTOR and NF-ĸB pathways

FHL2 deteriorates IL-1β induced inflammation, apoptosis, and extracellular matrix degradation in chondrocyte-like ATDC5 cells by mTOR and NF-ĸB pathways

Abstract Background The role of nuclear translocation in osteoarthritis (OA) pathogenesis has garnered increasing attention in recent years. Extensive research has demonstrated that FHL2 acts as a nuclear transmitter through interactions with other nuclear transcription factors. We aimed to investig...

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Bibliographic Details
Main Authors: Yicheng Li, Fei Wang, Baochao Ji, Abdusami Amati, Li Cao
Format: Article
Language:English
Published: BMC 2025-04-01
Series:BMC Musculoskeletal Disorders
Subjects:
FHL2
IL-1β
mTOR
NF-ĸB
Signaling pathway
Osteoarthritis
Online Access:https://doi.org/10.1186/s12891-025-08536-9
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