Supersensitivity Psychosis and Its Response to Asenapine in a Patient with Delusional Disorder
Supersensitivity psychosis is a recognized complication of long-term antipsychotic treatment, in which patients develop new or reemergent psychotic symptoms, generally accompanied by dyskinetic movements, due to prolonged dopamine receptor blockade and resultant supersensitivity. Though it is most c...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Case Reports in Psychiatry |
| Online Access: | http://dx.doi.org/10.1155/2014/215732 |
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| author | Ravi Philip Rajkumar |
| author_facet | Ravi Philip Rajkumar |
| author_sort | Ravi Philip Rajkumar |
| collection | DOAJ |
| description | Supersensitivity psychosis is a recognized complication of long-term antipsychotic treatment, in which patients develop new or reemergent psychotic symptoms, generally accompanied by dyskinetic movements, due to prolonged dopamine receptor blockade and resultant supersensitivity. Though it is most closely associated with schizophrenia and the use of typical antipsychotic agents, it has also been documented in patients with other diagnoses, and in those receiving atypical antipsychotics. There is no established treatment for this condition. In this paper, we describe a patient with persistent delusional disorder, jealous type, who developed a supersensitivity psychosis characterized by persecutory delusions, auditory hallucinations, and thought insertion in association with mild tardive dyskinesia. These symptoms resolved completely following six weeks of treatment with the second-generation antipsychotic asenapine, 20 mg/day. The mechanisms and implications of the patient’s symptomatology and response are discussed. |
| format | Article |
| id | doaj-art-abdfb5f06c30424d89de347e8437df3c |
| institution | Kabale University |
| issn | 2090-682X 2090-6838 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Psychiatry |
| spelling | doaj-art-abdfb5f06c30424d89de347e8437df3c2025-08-20T03:39:13ZengWileyCase Reports in Psychiatry2090-682X2090-68382014-01-01201410.1155/2014/215732215732Supersensitivity Psychosis and Its Response to Asenapine in a Patient with Delusional DisorderRavi Philip Rajkumar0Department of Psychiatry, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry 605 006, IndiaSupersensitivity psychosis is a recognized complication of long-term antipsychotic treatment, in which patients develop new or reemergent psychotic symptoms, generally accompanied by dyskinetic movements, due to prolonged dopamine receptor blockade and resultant supersensitivity. Though it is most closely associated with schizophrenia and the use of typical antipsychotic agents, it has also been documented in patients with other diagnoses, and in those receiving atypical antipsychotics. There is no established treatment for this condition. In this paper, we describe a patient with persistent delusional disorder, jealous type, who developed a supersensitivity psychosis characterized by persecutory delusions, auditory hallucinations, and thought insertion in association with mild tardive dyskinesia. These symptoms resolved completely following six weeks of treatment with the second-generation antipsychotic asenapine, 20 mg/day. The mechanisms and implications of the patient’s symptomatology and response are discussed.http://dx.doi.org/10.1155/2014/215732 |
| spellingShingle | Ravi Philip Rajkumar Supersensitivity Psychosis and Its Response to Asenapine in a Patient with Delusional Disorder Case Reports in Psychiatry |
| title | Supersensitivity Psychosis and Its Response to Asenapine in a Patient with Delusional Disorder |
| title_full | Supersensitivity Psychosis and Its Response to Asenapine in a Patient with Delusional Disorder |
| title_fullStr | Supersensitivity Psychosis and Its Response to Asenapine in a Patient with Delusional Disorder |
| title_full_unstemmed | Supersensitivity Psychosis and Its Response to Asenapine in a Patient with Delusional Disorder |
| title_short | Supersensitivity Psychosis and Its Response to Asenapine in a Patient with Delusional Disorder |
| title_sort | supersensitivity psychosis and its response to asenapine in a patient with delusional disorder |
| url | http://dx.doi.org/10.1155/2014/215732 |
| work_keys_str_mv | AT raviphiliprajkumar supersensitivitypsychosisanditsresponsetoasenapineinapatientwithdelusionaldisorder |