Investigation of the physical behavior of Magnesium Sulphate/Sucrose in pharmaceuticals at different temperatures
The physical behavior of MgSO4 as a drug additive in sucrose solution has been investigated. In the procedure, MgSO4 solutions were dissolved in three separate sucrose mixtures at varying temperatures ranging from 25 to 45 °C. Electrical conductivity, density, and viscosity of mixtures were measured...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-06-01
|
| Series: | Carbohydrate Polymer Technologies and Applications |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666893925001446 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849335779538501632 |
|---|---|
| author | Zaineb O. Ettarhouni Ali Elhamassi Suad E. Abughrin Fida S. ALaamin Salihu Ismail Ajaya Bhattarai |
| author_facet | Zaineb O. Ettarhouni Ali Elhamassi Suad E. Abughrin Fida S. ALaamin Salihu Ismail Ajaya Bhattarai |
| author_sort | Zaineb O. Ettarhouni |
| collection | DOAJ |
| description | The physical behavior of MgSO4 as a drug additive in sucrose solution has been investigated. In the procedure, MgSO4 solutions were dissolved in three separate sucrose mixtures at varying temperatures ranging from 25 to 45 °C. Electrical conductivity, density, and viscosity of mixtures were measured, and data were analyzed. Magnesium sulphate additives in medicine have been studied based on the Onsager equation to determine the molar conductance at infinite dilution, it was found that all mixtures behave as weak electrolytes based on the ion/disaccharide interactions. It was also found that the higher the temperature, the higher the electrical conductivity, and the lower the viscosity and density of these mixtures. UV–Vis spectroscopy can compare proposed additives with 10 % w/v MgSO4 injection to observe potential interactions or stability issues. |
| format | Article |
| id | doaj-art-abdecc0b6c8144358bf11f75e108d189 |
| institution | Kabale University |
| issn | 2666-8939 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Carbohydrate Polymer Technologies and Applications |
| spelling | doaj-art-abdecc0b6c8144358bf11f75e108d1892025-08-20T03:45:10ZengElsevierCarbohydrate Polymer Technologies and Applications2666-89392025-06-011010080610.1016/j.carpta.2025.100806Investigation of the physical behavior of Magnesium Sulphate/Sucrose in pharmaceuticals at different temperaturesZaineb O. Ettarhouni0Ali Elhamassi1Suad E. Abughrin2Fida S. ALaamin3Salihu Ismail4Ajaya Bhattarai5Department of Chemistry, Faculty of Science, University of Tripoli, Tripoli P.O. Box 13503, LibyaDepartment of Chemistry, Faculty of Science, University of Tripoli, Tripoli P.O. Box 13503, LibyaDepartment of Solar Cell, The Libyan Center for Solar Energy Research and Studies, Libyan Authority for Scientific Research, P.O. Box 30454, Tripoli, LibyaDepartment of Chemistry, Faculty of Science, University of Tripoli, Tripoli P.O. Box 13503, LibyaDepartment of Analytical Chemistry, Faculty of Science, Yusuf Maitama Sule University, PMB 3220 Kano, Nigeria; Department of Analytical Chemistry, Faculty of Pharmacy, Near East University, 99138, Nicosia, TRNC, Mersin 10, TurkeyDepartment of Chemistry, Mahendra Morang Adarsh Multiple Campus, Tribhuvan University, Biratnagar 56613, Nepal; Department of Chemistry, Indian Institute of Technology Madras, Chennai 600036, India; Corresponding author.The physical behavior of MgSO4 as a drug additive in sucrose solution has been investigated. In the procedure, MgSO4 solutions were dissolved in three separate sucrose mixtures at varying temperatures ranging from 25 to 45 °C. Electrical conductivity, density, and viscosity of mixtures were measured, and data were analyzed. Magnesium sulphate additives in medicine have been studied based on the Onsager equation to determine the molar conductance at infinite dilution, it was found that all mixtures behave as weak electrolytes based on the ion/disaccharide interactions. It was also found that the higher the temperature, the higher the electrical conductivity, and the lower the viscosity and density of these mixtures. UV–Vis spectroscopy can compare proposed additives with 10 % w/v MgSO4 injection to observe potential interactions or stability issues.http://www.sciencedirect.com/science/article/pii/S2666893925001446SucroseBeer-Lambert LawUV–Vis Spectroscopy |
| spellingShingle | Zaineb O. Ettarhouni Ali Elhamassi Suad E. Abughrin Fida S. ALaamin Salihu Ismail Ajaya Bhattarai Investigation of the physical behavior of Magnesium Sulphate/Sucrose in pharmaceuticals at different temperatures Carbohydrate Polymer Technologies and Applications Sucrose Beer-Lambert Law UV–Vis Spectroscopy |
| title | Investigation of the physical behavior of Magnesium Sulphate/Sucrose in pharmaceuticals at different temperatures |
| title_full | Investigation of the physical behavior of Magnesium Sulphate/Sucrose in pharmaceuticals at different temperatures |
| title_fullStr | Investigation of the physical behavior of Magnesium Sulphate/Sucrose in pharmaceuticals at different temperatures |
| title_full_unstemmed | Investigation of the physical behavior of Magnesium Sulphate/Sucrose in pharmaceuticals at different temperatures |
| title_short | Investigation of the physical behavior of Magnesium Sulphate/Sucrose in pharmaceuticals at different temperatures |
| title_sort | investigation of the physical behavior of magnesium sulphate sucrose in pharmaceuticals at different temperatures |
| topic | Sucrose Beer-Lambert Law UV–Vis Spectroscopy |
| url | http://www.sciencedirect.com/science/article/pii/S2666893925001446 |
| work_keys_str_mv | AT zaineboettarhouni investigationofthephysicalbehaviorofmagnesiumsulphatesucroseinpharmaceuticalsatdifferenttemperatures AT alielhamassi investigationofthephysicalbehaviorofmagnesiumsulphatesucroseinpharmaceuticalsatdifferenttemperatures AT suadeabughrin investigationofthephysicalbehaviorofmagnesiumsulphatesucroseinpharmaceuticalsatdifferenttemperatures AT fidasalaamin investigationofthephysicalbehaviorofmagnesiumsulphatesucroseinpharmaceuticalsatdifferenttemperatures AT salihuismail investigationofthephysicalbehaviorofmagnesiumsulphatesucroseinpharmaceuticalsatdifferenttemperatures AT ajayabhattarai investigationofthephysicalbehaviorofmagnesiumsulphatesucroseinpharmaceuticalsatdifferenttemperatures |