Combination of White Blood Cell Count to Mean Platelet Volume Ratio and Neutrophil-to-Platelet Ratio Predicts Long-Term Adverse Events in Patients with MINOCA

Background. White blood cell count to mean platelet volume ratio (WMR) and neutrophil-to-platelet ratio (NPR) have been demonstrated as prognostic inflammatory biomarkers of the acute coronary syndrome. We aimed to evaluate the prognostic value of WMR and NPR among myocardial infarction with nonobst...

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Main Authors: Ayman A. Mohammed, Lu Liu, Redhwan M. Mareai, Abdul-Quddus Mohammed, Guoqing Yin, Shekhar Singh, Yawei Xu, Fuad A. Abdu, Wenliang Che
Format: Article
Language:English
Published: Wiley 2022-01-01
Series:Mediators of Inflammation
Online Access:http://dx.doi.org/10.1155/2022/5642406
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author Ayman A. Mohammed
Lu Liu
Redhwan M. Mareai
Abdul-Quddus Mohammed
Guoqing Yin
Shekhar Singh
Yawei Xu
Fuad A. Abdu
Wenliang Che
author_facet Ayman A. Mohammed
Lu Liu
Redhwan M. Mareai
Abdul-Quddus Mohammed
Guoqing Yin
Shekhar Singh
Yawei Xu
Fuad A. Abdu
Wenliang Che
author_sort Ayman A. Mohammed
collection DOAJ
description Background. White blood cell count to mean platelet volume ratio (WMR) and neutrophil-to-platelet ratio (NPR) have been demonstrated as prognostic inflammatory biomarkers of the acute coronary syndrome. We aimed to evaluate the prognostic value of WMR and NPR among myocardial infarction with nonobstructive coronary arteries (MINOCA) patients. Method. A total of 274 MINOCA patients were enrolled. Baseline clinical data, blood cell panel, and biochemical parameters were evaluated. The patients were classified according to the medians of WMR and NPR. The primary endpoint of the present study was major adverse cardiovascular events (MACE). Multivariable Cox regression analysis was used to assess the effect of independent variables of WMR and NPR on the dependent variable (MACE). Result. The median values of WMR and NPR were 701 and 0.03, respectively. During the median follow-up of 28 months, a total of 58 incidences of MACE occurred. The MACE rate was more frequent in high WMR and high NPR patients. In Kaplan-Meier analysis, the incidence of MACE was higher in WMR>701 and NPR>0.03 (long-rank P=0.004 and P=0.002, respectively). The combined high WMR and high NPR showed a significantly higher rate of MACE (long-rank P=0.001). Cox regression analysis showed that the combined high WMR and high NPR were independent predictors of long-term MACE with the highest hazard ratio (HR, 2.511; 95% CI, 1.271 to 4.960; P=0.008). Conclusion. High WMR and NPR separately or in combination were correlated with increased risk of MACE among MINOCA patients, suggesting WMR and NPR may assist as a reliable inflammatory marker in risk prediction of MINOCA patients.
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spelling doaj-art-abdb2b3319394af7a692e65a9928c80e2025-02-03T01:23:38ZengWileyMediators of Inflammation1466-18612022-01-01202210.1155/2022/5642406Combination of White Blood Cell Count to Mean Platelet Volume Ratio and Neutrophil-to-Platelet Ratio Predicts Long-Term Adverse Events in Patients with MINOCAAyman A. Mohammed0Lu Liu1Redhwan M. Mareai2Abdul-Quddus Mohammed3Guoqing Yin4Shekhar Singh5Yawei Xu6Fuad A. Abdu7Wenliang Che8Department of CardiologyDepartment of CardiologyDepartment of CardiologyDepartment of CardiologyDepartment of CardiologyDepartment of CardiologyDepartment of CardiologyDepartment of CardiologyDepartment of CardiologyBackground. White blood cell count to mean platelet volume ratio (WMR) and neutrophil-to-platelet ratio (NPR) have been demonstrated as prognostic inflammatory biomarkers of the acute coronary syndrome. We aimed to evaluate the prognostic value of WMR and NPR among myocardial infarction with nonobstructive coronary arteries (MINOCA) patients. Method. A total of 274 MINOCA patients were enrolled. Baseline clinical data, blood cell panel, and biochemical parameters were evaluated. The patients were classified according to the medians of WMR and NPR. The primary endpoint of the present study was major adverse cardiovascular events (MACE). Multivariable Cox regression analysis was used to assess the effect of independent variables of WMR and NPR on the dependent variable (MACE). Result. The median values of WMR and NPR were 701 and 0.03, respectively. During the median follow-up of 28 months, a total of 58 incidences of MACE occurred. The MACE rate was more frequent in high WMR and high NPR patients. In Kaplan-Meier analysis, the incidence of MACE was higher in WMR>701 and NPR>0.03 (long-rank P=0.004 and P=0.002, respectively). The combined high WMR and high NPR showed a significantly higher rate of MACE (long-rank P=0.001). Cox regression analysis showed that the combined high WMR and high NPR were independent predictors of long-term MACE with the highest hazard ratio (HR, 2.511; 95% CI, 1.271 to 4.960; P=0.008). Conclusion. High WMR and NPR separately or in combination were correlated with increased risk of MACE among MINOCA patients, suggesting WMR and NPR may assist as a reliable inflammatory marker in risk prediction of MINOCA patients.http://dx.doi.org/10.1155/2022/5642406
spellingShingle Ayman A. Mohammed
Lu Liu
Redhwan M. Mareai
Abdul-Quddus Mohammed
Guoqing Yin
Shekhar Singh
Yawei Xu
Fuad A. Abdu
Wenliang Che
Combination of White Blood Cell Count to Mean Platelet Volume Ratio and Neutrophil-to-Platelet Ratio Predicts Long-Term Adverse Events in Patients with MINOCA
Mediators of Inflammation
title Combination of White Blood Cell Count to Mean Platelet Volume Ratio and Neutrophil-to-Platelet Ratio Predicts Long-Term Adverse Events in Patients with MINOCA
title_full Combination of White Blood Cell Count to Mean Platelet Volume Ratio and Neutrophil-to-Platelet Ratio Predicts Long-Term Adverse Events in Patients with MINOCA
title_fullStr Combination of White Blood Cell Count to Mean Platelet Volume Ratio and Neutrophil-to-Platelet Ratio Predicts Long-Term Adverse Events in Patients with MINOCA
title_full_unstemmed Combination of White Blood Cell Count to Mean Platelet Volume Ratio and Neutrophil-to-Platelet Ratio Predicts Long-Term Adverse Events in Patients with MINOCA
title_short Combination of White Blood Cell Count to Mean Platelet Volume Ratio and Neutrophil-to-Platelet Ratio Predicts Long-Term Adverse Events in Patients with MINOCA
title_sort combination of white blood cell count to mean platelet volume ratio and neutrophil to platelet ratio predicts long term adverse events in patients with minoca
url http://dx.doi.org/10.1155/2022/5642406
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