p47phox: A Central Regulator of NADPH Oxidase Function and a Promising Therapeutic Target in Redox-Related Diseases

p47phox: A Central Regulator of NADPH Oxidase Function and a Promising Therapeutic Target in Redox-Related Diseases

The NADPH oxidase 2 (NOX2) complex is a critical regulator of immune homeostasis. It is utilized by phagocytic leukocytes including neutrophils, monocytes, and macrophages to generate reactive oxygen species (ROS) that drive microbe clearance and modulate inflammatory responses. Within NOX2, the ess...

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Bibliographic Details
Main Authors: Madison E. Gamble, Sruthi Sureshkumar, Maria Janina Carrera Espinoza, Natalie L. Hakim, Claudia M. Espitia, Fangchao Bi, Kevin R. Kelly, Wei Wang, Steffan T. Nawrocki, Jennifer S. Carew
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Cells
Subjects:
p47phox
oxidative stress
redox
cancer
targeted therapy
Online Access:https://www.mdpi.com/2073-4409/14/14/1043
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