Arterial Stiffness and Markers of Atrial Myopathy
ABSTRACT Background Arterial stiffness, measured using carotid‐femoral pulse wave velocity (c‐f PWV) and heart rate‐corrected augmentation index (Aix75), is associated with cardiovascular disease, and in some studies incident atrial fibrillation (AF). In this cross‐sectional study, we aimed to inves...
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Wiley
2025-03-01
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| Series: | Annals of Noninvasive Electrocardiology |
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| Online Access: | https://doi.org/10.1111/anec.70044 |
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| author | Magdalena Okrajni Pyotr Platonov Iram Faqir Muhammad Fredrik Holmqvist Johan Economou Lundberg Anders Persson Cecilia Kennbäck Jeffrey S. Healey Gunnar Engström Linda S. Johnson |
| author_facet | Magdalena Okrajni Pyotr Platonov Iram Faqir Muhammad Fredrik Holmqvist Johan Economou Lundberg Anders Persson Cecilia Kennbäck Jeffrey S. Healey Gunnar Engström Linda S. Johnson |
| author_sort | Magdalena Okrajni |
| collection | DOAJ |
| description | ABSTRACT Background Arterial stiffness, measured using carotid‐femoral pulse wave velocity (c‐f PWV) and heart rate‐corrected augmentation index (Aix75), is associated with cardiovascular disease, and in some studies incident atrial fibrillation (AF). In this cross‐sectional study, we aimed to investigate whether arterial stiffness is associated with markers of atrial myopathy, which refers to structural and electrical changes in the atria that indicate increased AF risk. Methods We included 1050 participants (age 57 ± 4.3 years, 47% males) from the population‐based Swedish CArdioPulmonary bioImage Study with c‐f PWV and Aix75 data. A random subsample (n = 331) underwent echocardiography. The association between arterial stiffness and atrial myopathy markers was studied using multivariable‐adjusted negative binomial regression models for premature atrial complexes (PACs) on 24 h ECG, linear regression for P‐wave duration and left atrial volume index (LAVi), and logistic regression models for abnormal P‐wave terminal force in V1 (PWTFV1) and P‐wave axis. Results Arterial stiffness was associated with fewer PACs: incidence rate ratio (IRR) 0.45 (95% CI: 0.31 to 0.65, p < 0.001) per 1 m/s increase in c‐f PWV and IRR 0.66 (95% CI: 0.49 to 0.89, p = 0.01) per % increase in Aix75. There was no association between arterial stiffness and P‐wave indices, OR 1.09 (95% CI: 0.85 to 1.40), p = 0.50 for abnormal PWTFV1, and β −0.003 (−0.10 to 0.09), p = 0.95 for P‐wave duration, both per 1 m/s increase in c‐f PWV. Conclusions Arterial stiffness, measured as either c‐f PWV or Aix75, was associated with fewer PACs, whereas no association was found with P‐wave indices. The association between arterial stiffness and atrial myopathy is complex and merits further study. |
| format | Article |
| id | doaj-art-abdad9526d3045bc9435a743d7b7135b |
| institution | DOAJ |
| issn | 1082-720X 1542-474X |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Wiley |
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| series | Annals of Noninvasive Electrocardiology |
| spelling | doaj-art-abdad9526d3045bc9435a743d7b7135b2025-08-20T02:49:44ZengWileyAnnals of Noninvasive Electrocardiology1082-720X1542-474X2025-03-01302n/an/a10.1111/anec.70044Arterial Stiffness and Markers of Atrial MyopathyMagdalena Okrajni0Pyotr Platonov1Iram Faqir Muhammad2Fredrik Holmqvist3Johan Economou Lundberg4Anders Persson5Cecilia Kennbäck6Jeffrey S. Healey7Gunnar Engström8Linda S. Johnson9Department of Clinical Sciences, Malmö Lund University Malmö SwedenDepartment of Clinical Sciences, Lund Lund University Lund SwedenDepartment of Clinical Sciences, Malmö Lund University Malmö SwedenDepartment of Clinical Sciences, Lund Lund University Lund SwedenDepartment of Clinical Sciences, Malmö Lund University Malmö SwedenDepartment of Clinical Sciences, Malmö Lund University Malmö SwedenDepartment of Clinical Sciences, Malmö Lund University Malmö SwedenPopulation Health Research Institute McMaster University Hamilton Ontario CanadaDepartment of Clinical Sciences, Malmö Lund University Malmö SwedenDepartment of Clinical Sciences, Malmö Lund University Malmö SwedenABSTRACT Background Arterial stiffness, measured using carotid‐femoral pulse wave velocity (c‐f PWV) and heart rate‐corrected augmentation index (Aix75), is associated with cardiovascular disease, and in some studies incident atrial fibrillation (AF). In this cross‐sectional study, we aimed to investigate whether arterial stiffness is associated with markers of atrial myopathy, which refers to structural and electrical changes in the atria that indicate increased AF risk. Methods We included 1050 participants (age 57 ± 4.3 years, 47% males) from the population‐based Swedish CArdioPulmonary bioImage Study with c‐f PWV and Aix75 data. A random subsample (n = 331) underwent echocardiography. The association between arterial stiffness and atrial myopathy markers was studied using multivariable‐adjusted negative binomial regression models for premature atrial complexes (PACs) on 24 h ECG, linear regression for P‐wave duration and left atrial volume index (LAVi), and logistic regression models for abnormal P‐wave terminal force in V1 (PWTFV1) and P‐wave axis. Results Arterial stiffness was associated with fewer PACs: incidence rate ratio (IRR) 0.45 (95% CI: 0.31 to 0.65, p < 0.001) per 1 m/s increase in c‐f PWV and IRR 0.66 (95% CI: 0.49 to 0.89, p = 0.01) per % increase in Aix75. There was no association between arterial stiffness and P‐wave indices, OR 1.09 (95% CI: 0.85 to 1.40), p = 0.50 for abnormal PWTFV1, and β −0.003 (−0.10 to 0.09), p = 0.95 for P‐wave duration, both per 1 m/s increase in c‐f PWV. Conclusions Arterial stiffness, measured as either c‐f PWV or Aix75, was associated with fewer PACs, whereas no association was found with P‐wave indices. The association between arterial stiffness and atrial myopathy is complex and merits further study.https://doi.org/10.1111/anec.7004424 h ECGarterial stiffnessatrial myopathyleft atrial volumepremature atrial complexesP‐wave |
| spellingShingle | Magdalena Okrajni Pyotr Platonov Iram Faqir Muhammad Fredrik Holmqvist Johan Economou Lundberg Anders Persson Cecilia Kennbäck Jeffrey S. Healey Gunnar Engström Linda S. Johnson Arterial Stiffness and Markers of Atrial Myopathy Annals of Noninvasive Electrocardiology 24 h ECG arterial stiffness atrial myopathy left atrial volume premature atrial complexes P‐wave |
| title | Arterial Stiffness and Markers of Atrial Myopathy |
| title_full | Arterial Stiffness and Markers of Atrial Myopathy |
| title_fullStr | Arterial Stiffness and Markers of Atrial Myopathy |
| title_full_unstemmed | Arterial Stiffness and Markers of Atrial Myopathy |
| title_short | Arterial Stiffness and Markers of Atrial Myopathy |
| title_sort | arterial stiffness and markers of atrial myopathy |
| topic | 24 h ECG arterial stiffness atrial myopathy left atrial volume premature atrial complexes P‐wave |
| url | https://doi.org/10.1111/anec.70044 |
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