Molecular docking and biological evaluation of a novel IWS1 inhibitor for the treatment of human retroperitoneal liposarcoma

Molecular docking and biological evaluation of a novel IWS1 inhibitor for the treatment of human retroperitoneal liposarcoma

Abstract IWS1 is a key assembly factor of the RNA polymerase II (RNAPII) elongation complex, and its overexpression is associated with worse outcomes in patients with liposarcoma (LPS). This study aimed to identify compounds that can disrupt the IWS1/Spt6 interaction and assess their biological effe...

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Main Authors: Marina Goryunova, Yiran He, Carson Karakis, Elizaveta K. Titerina, Ana I. Salazar-Puerta, Sayumi Tahara, Nipin Sp, Neil N. Thakkar, Orlando Cómbita-Heredia, Kavya Dathathreya, Alessandro La Ferlita, Yanping Xu, Zhentao Zhang, Raphael Pollock, Daniel Gallego-Perez, Hua Zhu, Christopher M. Hadad, Joal D. Beane
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-025-07215-y
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