Hippocampal and cortical high-frequency oscillations orchestrate human semantic networks during word list memory
Summary: Episodic memory requires the precise coordination between the hippocampus and distributed cortical regions. This may be facilitated by bursts of brain activity called high-frequency oscillations (HFOs). We hypothesized that HFOs activate specific networks during memory retrieval and aimed t...
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Elsevier
2025-04-01
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| Series: | iScience |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004225004328 |
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| author | Akash Mishra Serdar Akkol Elizabeth Espinal Noah Markowitz Gelana Tostaeva Elisabeth Freund Ashesh D. Mehta Stephan Bickel |
| author_facet | Akash Mishra Serdar Akkol Elizabeth Espinal Noah Markowitz Gelana Tostaeva Elisabeth Freund Ashesh D. Mehta Stephan Bickel |
| author_sort | Akash Mishra |
| collection | DOAJ |
| description | Summary: Episodic memory requires the precise coordination between the hippocampus and distributed cortical regions. This may be facilitated by bursts of brain activity called high-frequency oscillations (HFOs). We hypothesized that HFOs activate specific networks during memory retrieval and aimed to describe the electrophysiological properties of HFO-associated activity. To study this, we recorded intracranial electroencephalography while human participants performed a list learning task. Hippocampal HFOs (hHFOs) increased during encoding and retrieval, and these increases correlated with memory performance. During retrieval, hHFOs demonstrated activation of semantic processing regions that were previously active during encoding. This consisted of broadband high-frequency activity (HFA) and cortical HFOs. HFOs in the anterior temporal lobe, a major semantic hub, co-occurred with hHFOs, particularly during retrieval. These coincident HFOs were associated with greater cortical HFA and cortical theta bursts. Hence, HFOs may support synchronization of activity across distributed nodes of the hippocampal-cortical memory network. |
| format | Article |
| id | doaj-art-abcdb276c1864d0da57daa3296b8d2c6 |
| institution | OA Journals |
| issn | 2589-0042 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj-art-abcdb276c1864d0da57daa3296b8d2c62025-08-20T01:55:11ZengElsevieriScience2589-00422025-04-0128411217110.1016/j.isci.2025.112171Hippocampal and cortical high-frequency oscillations orchestrate human semantic networks during word list memoryAkash Mishra0Serdar Akkol1Elizabeth Espinal2Noah Markowitz3Gelana Tostaeva4Elisabeth Freund5Ashesh D. Mehta6Stephan Bickel7Northwell, New Hyde Park, NY, USA; Departments of Neurosurgery and Neurology, Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY, USA; Corresponding authorNorthwell, New Hyde Park, NY, USA; Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, USA; Elmezzi Graduate School of Molecular Medicine, Manhasset, NY, USANorthwell, New Hyde Park, NY, USA; Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, USA; Department of Psychological and Brain Sciences, Drexel University, Philadelphia, PA, USANorthwell, New Hyde Park, NY, USA; Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, USANorthwell, New Hyde Park, NY, USA; Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, USANorthwell, New Hyde Park, NY, USA; Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, USANorthwell, New Hyde Park, NY, USA; Departments of Neurosurgery and Neurology, Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY, USANorthwell, New Hyde Park, NY, USA; Departments of Neurosurgery and Neurology, Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY, USA; Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, USA; Center for Biomedical Imaging and Neuromodulation, Nathan Kline Institute, Orangeburg, NY, USA; Corresponding authorSummary: Episodic memory requires the precise coordination between the hippocampus and distributed cortical regions. This may be facilitated by bursts of brain activity called high-frequency oscillations (HFOs). We hypothesized that HFOs activate specific networks during memory retrieval and aimed to describe the electrophysiological properties of HFO-associated activity. To study this, we recorded intracranial electroencephalography while human participants performed a list learning task. Hippocampal HFOs (hHFOs) increased during encoding and retrieval, and these increases correlated with memory performance. During retrieval, hHFOs demonstrated activation of semantic processing regions that were previously active during encoding. This consisted of broadband high-frequency activity (HFA) and cortical HFOs. HFOs in the anterior temporal lobe, a major semantic hub, co-occurred with hHFOs, particularly during retrieval. These coincident HFOs were associated with greater cortical HFA and cortical theta bursts. Hence, HFOs may support synchronization of activity across distributed nodes of the hippocampal-cortical memory network.http://www.sciencedirect.com/science/article/pii/S2589004225004328Cognitive neuroscienceLinguistics |
| spellingShingle | Akash Mishra Serdar Akkol Elizabeth Espinal Noah Markowitz Gelana Tostaeva Elisabeth Freund Ashesh D. Mehta Stephan Bickel Hippocampal and cortical high-frequency oscillations orchestrate human semantic networks during word list memory iScience Cognitive neuroscience Linguistics |
| title | Hippocampal and cortical high-frequency oscillations orchestrate human semantic networks during word list memory |
| title_full | Hippocampal and cortical high-frequency oscillations orchestrate human semantic networks during word list memory |
| title_fullStr | Hippocampal and cortical high-frequency oscillations orchestrate human semantic networks during word list memory |
| title_full_unstemmed | Hippocampal and cortical high-frequency oscillations orchestrate human semantic networks during word list memory |
| title_short | Hippocampal and cortical high-frequency oscillations orchestrate human semantic networks during word list memory |
| title_sort | hippocampal and cortical high frequency oscillations orchestrate human semantic networks during word list memory |
| topic | Cognitive neuroscience Linguistics |
| url | http://www.sciencedirect.com/science/article/pii/S2589004225004328 |
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