Severe Aplastic Anemia Developed after Thymectomy: A Case Report and Literature Review
Thymus neoplasms are frequently related to paraneoplastic autoimmune manifestations. Its most common associations are myasthenia gravis and pure red cell aplasia. Aplastic anemia has been increasingly documented as an initial presentation of thymoma. Nevertheless, its development after successful su...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2020/7819321 |
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| author | Bruna Cristine Duarte Rodrigues Pedro José Galvão Freire Beatriz Pinto e Siqueira Campos Juliana Oliveira Vieira Pedro Alves da Cruz Gouveia |
| author_facet | Bruna Cristine Duarte Rodrigues Pedro José Galvão Freire Beatriz Pinto e Siqueira Campos Juliana Oliveira Vieira Pedro Alves da Cruz Gouveia |
| author_sort | Bruna Cristine Duarte Rodrigues |
| collection | DOAJ |
| description | Thymus neoplasms are frequently related to paraneoplastic autoimmune manifestations. Its most common associations are myasthenia gravis and pure red cell aplasia. Aplastic anemia has been increasingly documented as an initial presentation of thymoma. Nevertheless, its development after successful surgical resection of thymoma is a rare condition. We report a case of a 53-year-old man with severe aplastic anemia preceded by amegakaryocytic thrombocytopenia three years after thymectomy with no signs of disease recurrence. He underwent immunosuppressive therapy with cyclosporine 5 mg/kg/day and prednisone 2 mg/kg/day for six weeks. Considering the availability of a compatible donor, allogeneic stem cell transplantation was carried out. However, the patient died 11 days after transplant. A literature review was conducted, and another ten cases of aplastic anemia, diagnosed three months to four years after thymectomy, were identified. These cases suggest persistence of peripheral self-reactive T lymphocytes even years after tumor definitive treatment. |
| format | Article |
| id | doaj-art-abc8d6526da745df821496ea74751c94 |
| institution | OA Journals |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-abc8d6526da745df821496ea74751c942025-08-20T02:20:13ZengWileyCase Reports in Hematology2090-65602090-65792020-01-01202010.1155/2020/78193217819321Severe Aplastic Anemia Developed after Thymectomy: A Case Report and Literature ReviewBruna Cristine Duarte Rodrigues0Pedro José Galvão Freire1Beatriz Pinto e Siqueira Campos2Juliana Oliveira Vieira3Pedro Alves da Cruz Gouveia4Internal Medicine Service, Federal University of Pernambuco, Recife, PE, BrazilInternal Medicine Service, Federal University of Pernambuco, Recife, PE, BrazilInternal Medicine Service, Federal University of Pernambuco, Recife, PE, BrazilHematology Service, Federal University of Pernambuco, Recife, PE, BrazilInternal Medicine Service, Federal University of Pernambuco, Recife, PE, BrazilThymus neoplasms are frequently related to paraneoplastic autoimmune manifestations. Its most common associations are myasthenia gravis and pure red cell aplasia. Aplastic anemia has been increasingly documented as an initial presentation of thymoma. Nevertheless, its development after successful surgical resection of thymoma is a rare condition. We report a case of a 53-year-old man with severe aplastic anemia preceded by amegakaryocytic thrombocytopenia three years after thymectomy with no signs of disease recurrence. He underwent immunosuppressive therapy with cyclosporine 5 mg/kg/day and prednisone 2 mg/kg/day for six weeks. Considering the availability of a compatible donor, allogeneic stem cell transplantation was carried out. However, the patient died 11 days after transplant. A literature review was conducted, and another ten cases of aplastic anemia, diagnosed three months to four years after thymectomy, were identified. These cases suggest persistence of peripheral self-reactive T lymphocytes even years after tumor definitive treatment.http://dx.doi.org/10.1155/2020/7819321 |
| spellingShingle | Bruna Cristine Duarte Rodrigues Pedro José Galvão Freire Beatriz Pinto e Siqueira Campos Juliana Oliveira Vieira Pedro Alves da Cruz Gouveia Severe Aplastic Anemia Developed after Thymectomy: A Case Report and Literature Review Case Reports in Hematology |
| title | Severe Aplastic Anemia Developed after Thymectomy: A Case Report and Literature Review |
| title_full | Severe Aplastic Anemia Developed after Thymectomy: A Case Report and Literature Review |
| title_fullStr | Severe Aplastic Anemia Developed after Thymectomy: A Case Report and Literature Review |
| title_full_unstemmed | Severe Aplastic Anemia Developed after Thymectomy: A Case Report and Literature Review |
| title_short | Severe Aplastic Anemia Developed after Thymectomy: A Case Report and Literature Review |
| title_sort | severe aplastic anemia developed after thymectomy a case report and literature review |
| url | http://dx.doi.org/10.1155/2020/7819321 |
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