Epilepsy in onchocerciasis endemic areas: systematic review and meta-analysis of population-based surveys.
<h4>Objective</h4>We sought to evaluate the relationship between onchocerciasis prevalence and that of epilepsy using available data collected at community level.<h4>Design</h4>We conducted a systematic review and meta-regression of available data.<h4>Data sources</h...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2009-06-01
|
| Series: | PLoS Neglected Tropical Diseases |
| Online Access: | https://doi.org/10.1371/journal.pntd.0000461 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849682963397083136 |
|---|---|
| author | Sébastien D S Pion Christoph Kaiser Fernand Boutros-Toni Amandine Cournil Melanie M Taylor Stefanie E O Meredith Ansgar Stufe Ione Bertocchi Walter Kipp Pierre-Marie Preux Michel Boussinesq |
| author_facet | Sébastien D S Pion Christoph Kaiser Fernand Boutros-Toni Amandine Cournil Melanie M Taylor Stefanie E O Meredith Ansgar Stufe Ione Bertocchi Walter Kipp Pierre-Marie Preux Michel Boussinesq |
| author_sort | Sébastien D S Pion |
| collection | DOAJ |
| description | <h4>Objective</h4>We sought to evaluate the relationship between onchocerciasis prevalence and that of epilepsy using available data collected at community level.<h4>Design</h4>We conducted a systematic review and meta-regression of available data.<h4>Data sources</h4>Electronic and paper records on subject area ever produced up to February 2008.<h4>Review methods</h4>We searched for population-based studies reporting on the prevalence of epilepsy in communities for which onchocerciasis prevalence was available or could be estimated. Two authors independently assessed eligibility and study quality and extracted data. The estimation of point prevalence of onchocerciasis was standardized across studies using appropriate correction factors. Variation in epilepsy prevalence was then analyzed as a function of onchocerciasis endemicity using random-effect logistic models.<h4>Results</h4>Eight studies from west (Benin and Nigeria), central (Cameroon and Central African Republic) and east Africa (Uganda, Tanzania and Burundi) met the criteria for inclusion and analysis. Ninety-one communities with a total population of 79,270 individuals screened for epilepsy were included in the analysis. The prevalence of epilepsy ranged from 0 to 8.7% whereas that of onchocerciasis ranged from 5.2 to 100%. Variation in epilepsy prevalence was consistent with a logistic function of onchocerciasis prevalence, with epilepsy prevalence being increased, on average, by 0.4% for each 10% increase in onchocerciasis prevalence.<h4>Conclusion</h4>These results give further evidence that onchocerciasis is associated with epilepsy and that the disease burden of onchocerciasis might have to be re-estimated by taking into account this relationship. |
| format | Article |
| id | doaj-art-abc52c3bd9c34df5a7f80785e25fe754 |
| institution | DOAJ |
| issn | 1935-2727 1935-2735 |
| language | English |
| publishDate | 2009-06-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Neglected Tropical Diseases |
| spelling | doaj-art-abc52c3bd9c34df5a7f80785e25fe7542025-08-20T03:24:02ZengPublic Library of Science (PLoS)PLoS Neglected Tropical Diseases1935-27271935-27352009-06-0136e46110.1371/journal.pntd.0000461Epilepsy in onchocerciasis endemic areas: systematic review and meta-analysis of population-based surveys.Sébastien D S PionChristoph KaiserFernand Boutros-ToniAmandine CournilMelanie M TaylorStefanie E O MeredithAnsgar StufeIone BertocchiWalter KippPierre-Marie PreuxMichel Boussinesq<h4>Objective</h4>We sought to evaluate the relationship between onchocerciasis prevalence and that of epilepsy using available data collected at community level.<h4>Design</h4>We conducted a systematic review and meta-regression of available data.<h4>Data sources</h4>Electronic and paper records on subject area ever produced up to February 2008.<h4>Review methods</h4>We searched for population-based studies reporting on the prevalence of epilepsy in communities for which onchocerciasis prevalence was available or could be estimated. Two authors independently assessed eligibility and study quality and extracted data. The estimation of point prevalence of onchocerciasis was standardized across studies using appropriate correction factors. Variation in epilepsy prevalence was then analyzed as a function of onchocerciasis endemicity using random-effect logistic models.<h4>Results</h4>Eight studies from west (Benin and Nigeria), central (Cameroon and Central African Republic) and east Africa (Uganda, Tanzania and Burundi) met the criteria for inclusion and analysis. Ninety-one communities with a total population of 79,270 individuals screened for epilepsy were included in the analysis. The prevalence of epilepsy ranged from 0 to 8.7% whereas that of onchocerciasis ranged from 5.2 to 100%. Variation in epilepsy prevalence was consistent with a logistic function of onchocerciasis prevalence, with epilepsy prevalence being increased, on average, by 0.4% for each 10% increase in onchocerciasis prevalence.<h4>Conclusion</h4>These results give further evidence that onchocerciasis is associated with epilepsy and that the disease burden of onchocerciasis might have to be re-estimated by taking into account this relationship.https://doi.org/10.1371/journal.pntd.0000461 |
| spellingShingle | Sébastien D S Pion Christoph Kaiser Fernand Boutros-Toni Amandine Cournil Melanie M Taylor Stefanie E O Meredith Ansgar Stufe Ione Bertocchi Walter Kipp Pierre-Marie Preux Michel Boussinesq Epilepsy in onchocerciasis endemic areas: systematic review and meta-analysis of population-based surveys. PLoS Neglected Tropical Diseases |
| title | Epilepsy in onchocerciasis endemic areas: systematic review and meta-analysis of population-based surveys. |
| title_full | Epilepsy in onchocerciasis endemic areas: systematic review and meta-analysis of population-based surveys. |
| title_fullStr | Epilepsy in onchocerciasis endemic areas: systematic review and meta-analysis of population-based surveys. |
| title_full_unstemmed | Epilepsy in onchocerciasis endemic areas: systematic review and meta-analysis of population-based surveys. |
| title_short | Epilepsy in onchocerciasis endemic areas: systematic review and meta-analysis of population-based surveys. |
| title_sort | epilepsy in onchocerciasis endemic areas systematic review and meta analysis of population based surveys |
| url | https://doi.org/10.1371/journal.pntd.0000461 |
| work_keys_str_mv | AT sebastiendspion epilepsyinonchocerciasisendemicareassystematicreviewandmetaanalysisofpopulationbasedsurveys AT christophkaiser epilepsyinonchocerciasisendemicareassystematicreviewandmetaanalysisofpopulationbasedsurveys AT fernandboutrostoni epilepsyinonchocerciasisendemicareassystematicreviewandmetaanalysisofpopulationbasedsurveys AT amandinecournil epilepsyinonchocerciasisendemicareassystematicreviewandmetaanalysisofpopulationbasedsurveys AT melaniemtaylor epilepsyinonchocerciasisendemicareassystematicreviewandmetaanalysisofpopulationbasedsurveys AT stefanieeomeredith epilepsyinonchocerciasisendemicareassystematicreviewandmetaanalysisofpopulationbasedsurveys AT ansgarstufe epilepsyinonchocerciasisendemicareassystematicreviewandmetaanalysisofpopulationbasedsurveys AT ionebertocchi epilepsyinonchocerciasisendemicareassystematicreviewandmetaanalysisofpopulationbasedsurveys AT walterkipp epilepsyinonchocerciasisendemicareassystematicreviewandmetaanalysisofpopulationbasedsurveys AT pierremariepreux epilepsyinonchocerciasisendemicareassystematicreviewandmetaanalysisofpopulationbasedsurveys AT michelboussinesq epilepsyinonchocerciasisendemicareassystematicreviewandmetaanalysisofpopulationbasedsurveys |