Comparison of Zn, Cu, and Fe Content in Hair and Serum in Alopecia Areata Patients with Normal Group
Background. Alopecia areata (AA) is an autoimmune condition, in which hair is lost from some areas of the body. Though its etiopathogenesis is not fully understood, there are claims that imbalance of trace elements may trigger the onset of AA, by distorting immune functions. In this study, we tried...
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| Format: | Article |
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Wiley
2014-01-01
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| Series: | Dermatology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2014/784863 |
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| author | Ladan Dastgheib Zohreh Mostafavi-pour Ahmad Adnan Abdorazagh Zahra Khoshdel Maryam Sadat Sadati Iman Ahrari Sajjad Ahrari Mahsa Ghavipisheh |
| author_facet | Ladan Dastgheib Zohreh Mostafavi-pour Ahmad Adnan Abdorazagh Zahra Khoshdel Maryam Sadat Sadati Iman Ahrari Sajjad Ahrari Mahsa Ghavipisheh |
| author_sort | Ladan Dastgheib |
| collection | DOAJ |
| description | Background. Alopecia areata (AA) is an autoimmune condition, in which hair is lost from some areas of the body. Though its etiopathogenesis is not fully understood, there are claims that imbalance of trace elements may trigger the onset of AA, by distorting immune functions. In this study, we tried to investigate the relationship between AA and iron, zinc, and copper levels of serum and hair. Materials and Methods. Sixteen female patients with AA (14–40 years old) and 27 healthy female controls were enrolled in this study. Serum and hair level of iron, zinc, and copper were measured by flame emission spectroscopy. The resulting data was analyzed with SPSS15. Results. We did not detect a significant difference in the serum and hair level of iron, zinc, and copper between patients and controls. There was a significant correlation between serum and hair level of iron (r=0.504, P=0.001), zinc (r=0.684, P=0.0001), and copper (r=0.759, P=0.0001) in patients and controls. Discussion and Conclusion. According to this study, there was no statistically significant difference between trace elements among AA patients and controls. So the trace elements level in hair and serum may not be relevant to the immunologic dysfunction that exists in AA patients. |
| format | Article |
| id | doaj-art-abc36af0b23048e8a80f708f4f3d3cdd |
| institution | OA Journals |
| issn | 1687-6105 1687-6113 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Dermatology Research and Practice |
| spelling | doaj-art-abc36af0b23048e8a80f708f4f3d3cdd2025-08-20T02:20:13ZengWileyDermatology Research and Practice1687-61051687-61132014-01-01201410.1155/2014/784863784863Comparison of Zn, Cu, and Fe Content in Hair and Serum in Alopecia Areata Patients with Normal GroupLadan Dastgheib0Zohreh Mostafavi-pour1Ahmad Adnan Abdorazagh2Zahra Khoshdel3Maryam Sadat Sadati4Iman Ahrari5Sajjad Ahrari6Mahsa Ghavipisheh7Molecular Dermatology Research Center, Dermatology Department, Shiraz University of Medical Sciences, Shiraz, IranMaternal-Fetal Medicine Research Center, Hafez Hospital, Shiraz University of Medical Sciences, Shiraz, IranMolecular Dermatology Research Center, Dermatology Department, Shiraz University of Medical Sciences, Shiraz, IranRecombinant Protein Laboratory, Department of Biochemistry, Shiraz University of Medical Sciences, Shiraz, IranMolecular Dermatology Research Center, Dermatology Department, Shiraz University of Medical Sciences, Shiraz, IranStudent Research Committee, Shiraz University of Medical Sciences, Shiraz, IranDepartment of Biology, Shiraz University, Shiraz, IranStudent Research Committee, Fasa University of Medical Sciences, Fasa, IranBackground. Alopecia areata (AA) is an autoimmune condition, in which hair is lost from some areas of the body. Though its etiopathogenesis is not fully understood, there are claims that imbalance of trace elements may trigger the onset of AA, by distorting immune functions. In this study, we tried to investigate the relationship between AA and iron, zinc, and copper levels of serum and hair. Materials and Methods. Sixteen female patients with AA (14–40 years old) and 27 healthy female controls were enrolled in this study. Serum and hair level of iron, zinc, and copper were measured by flame emission spectroscopy. The resulting data was analyzed with SPSS15. Results. We did not detect a significant difference in the serum and hair level of iron, zinc, and copper between patients and controls. There was a significant correlation between serum and hair level of iron (r=0.504, P=0.001), zinc (r=0.684, P=0.0001), and copper (r=0.759, P=0.0001) in patients and controls. Discussion and Conclusion. According to this study, there was no statistically significant difference between trace elements among AA patients and controls. So the trace elements level in hair and serum may not be relevant to the immunologic dysfunction that exists in AA patients.http://dx.doi.org/10.1155/2014/784863 |
| spellingShingle | Ladan Dastgheib Zohreh Mostafavi-pour Ahmad Adnan Abdorazagh Zahra Khoshdel Maryam Sadat Sadati Iman Ahrari Sajjad Ahrari Mahsa Ghavipisheh Comparison of Zn, Cu, and Fe Content in Hair and Serum in Alopecia Areata Patients with Normal Group Dermatology Research and Practice |
| title | Comparison of Zn, Cu, and Fe Content in Hair and Serum in Alopecia Areata Patients with Normal Group |
| title_full | Comparison of Zn, Cu, and Fe Content in Hair and Serum in Alopecia Areata Patients with Normal Group |
| title_fullStr | Comparison of Zn, Cu, and Fe Content in Hair and Serum in Alopecia Areata Patients with Normal Group |
| title_full_unstemmed | Comparison of Zn, Cu, and Fe Content in Hair and Serum in Alopecia Areata Patients with Normal Group |
| title_short | Comparison of Zn, Cu, and Fe Content in Hair and Serum in Alopecia Areata Patients with Normal Group |
| title_sort | comparison of zn cu and fe content in hair and serum in alopecia areata patients with normal group |
| url | http://dx.doi.org/10.1155/2014/784863 |
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