Spectrophotometric determination of Metronidazole and Metronidazole benzoate via first and Second Derivative order spectroscopy
A New Spectrophotometric Methods are improved for determination Metronidazole (MTZ) and Metronidazolebenzoate (MTZB) depending on1STand 2nd derivative spectrum of the two drugs by using ethanol as a solvent. Many techniques were proportionated with concentration (peak high to base line, peak to peak...
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University of Baghdad, College of Science for Women
2017-06-01
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| Series: | مجلة بغداد للعلوم |
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| Online Access: | http://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/2367 |
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| description | A New Spectrophotometric Methods are improved for determination Metronidazole (MTZ) and Metronidazolebenzoate (MTZB) depending on1STand 2nd derivative spectrum of the two drugs by using ethanol as a solvent. Many techniques were proportionated with concentration (peak high to base line, peak to peak and peak area). The linearity of the methodsranged between(1-25µg.ml-1) is obtained. The results were precise and accurate throw RSD% were between (0.041-0.751%) and (0.0331-0.452%), Rec% values between (97.78, 101.87%) and (98.033-102.39%) while the LOD between (0.051-0.231 µg.ml-1) and (0.074-1.04 µg.ml-1) and LOQ between (0.170-0.770µg.ml-1) and (0.074-0.313 µg.ml-1) of (MTZ) and of (MTZB) respectively. These Methods were successfully applied to determination of (MTZ) and (MTZB) in the pharmaceutical preparatio; ns |
| format | Article |
| id | doaj-art-abbdb27b007e485d91f5895fd328a5f9 |
| institution | DOAJ |
| issn | 2078-8665 2411-7986 |
| language | English |
| publishDate | 2017-06-01 |
| publisher | University of Baghdad, College of Science for Women |
| record_format | Article |
| series | مجلة بغداد للعلوم |
| spelling | doaj-art-abbdb27b007e485d91f5895fd328a5f92025-08-20T02:54:40ZengUniversity of Baghdad, College of Science for Womenمجلة بغداد للعلوم2078-86652411-79862017-06-0114210.21123/bsj.14.2.320-327Spectrophotometric determination of Metronidazole and Metronidazole benzoate via first and Second Derivative order spectroscopyBaghdad Science JournalA New Spectrophotometric Methods are improved for determination Metronidazole (MTZ) and Metronidazolebenzoate (MTZB) depending on1STand 2nd derivative spectrum of the two drugs by using ethanol as a solvent. Many techniques were proportionated with concentration (peak high to base line, peak to peak and peak area). The linearity of the methodsranged between(1-25µg.ml-1) is obtained. The results were precise and accurate throw RSD% were between (0.041-0.751%) and (0.0331-0.452%), Rec% values between (97.78, 101.87%) and (98.033-102.39%) while the LOD between (0.051-0.231 µg.ml-1) and (0.074-1.04 µg.ml-1) and LOQ between (0.170-0.770µg.ml-1) and (0.074-0.313 µg.ml-1) of (MTZ) and of (MTZB) respectively. These Methods were successfully applied to determination of (MTZ) and (MTZB) in the pharmaceutical preparatio; nshttp://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/2367Spectrophotometric, determination, Metronidazole and Metronidazole Benzoate, First and second order derivative of spectrum |
| spellingShingle | Baghdad Science Journal Spectrophotometric determination of Metronidazole and Metronidazole benzoate via first and Second Derivative order spectroscopy مجلة بغداد للعلوم Spectrophotometric, determination, Metronidazole and Metronidazole Benzoate, First and second order derivative of spectrum |
| title | Spectrophotometric determination of Metronidazole and Metronidazole benzoate via first and Second Derivative order spectroscopy |
| title_full | Spectrophotometric determination of Metronidazole and Metronidazole benzoate via first and Second Derivative order spectroscopy |
| title_fullStr | Spectrophotometric determination of Metronidazole and Metronidazole benzoate via first and Second Derivative order spectroscopy |
| title_full_unstemmed | Spectrophotometric determination of Metronidazole and Metronidazole benzoate via first and Second Derivative order spectroscopy |
| title_short | Spectrophotometric determination of Metronidazole and Metronidazole benzoate via first and Second Derivative order spectroscopy |
| title_sort | spectrophotometric determination of metronidazole and metronidazole benzoate via first and second derivative order spectroscopy |
| topic | Spectrophotometric, determination, Metronidazole and Metronidazole Benzoate, First and second order derivative of spectrum |
| url | http://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/2367 |
| work_keys_str_mv | AT baghdadsciencejournal spectrophotometricdeterminationofmetronidazoleandmetronidazolebenzoateviafirstandsecondderivativeorderspectroscopy |