Moracin M derivative targeting PDE4 for the treatment of psoriasis
Phosphodiesterase-4 (PDE4), a member of the phosphodiesterase superfamily, has highly important roles in cyclic nucleotide signaling pathways and a variety of skin disorders. Blocking PDE4 activity with PDE4 inhibitors increases intracellular cAMP levels and effectively relieves the skin inflammator...
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| Main Authors: | Liru Chen, Deyan Wu, Sen Wang, Lingyu Wu, Youyou Chen, Baoli Li, Haibin Luo, Jian Li, Wenwen Liu |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Compuscript Ltd
2025-02-01
|
| Series: | Acta Materia Medica |
| Online Access: | https://www.scienceopen.com/hosted-document?doi=10.15212/AMM-2024-0086 |
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