Sex‐Specific Impact of Metabolic Dysfunction‐Associated Fatty Liver Disease on Incident Cardiovascular Diseases and Mortality
ABSTRACT Background and Aims Considering recent revisions in the nomenclature for fatty liver disease, alongside limited data on sex‐specific differences in its cardiovascular/mortality outcomes, this study aims to investigate the prevalence and impact of metabolic‐associated fatty liver disease (MA...
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Wiley
2025-05-01
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| Series: | Endocrinology, Diabetes & Metabolism |
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| Online Access: | https://doi.org/10.1002/edm2.70035 |
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| author | Mahsa Abbaszadeh Farhad Hosseinpanah Maryam Tohidi Sahar Karimpour Reyhan Maryam Mahdavi Majid Valizadeh |
| author_facet | Mahsa Abbaszadeh Farhad Hosseinpanah Maryam Tohidi Sahar Karimpour Reyhan Maryam Mahdavi Majid Valizadeh |
| author_sort | Mahsa Abbaszadeh |
| collection | DOAJ |
| description | ABSTRACT Background and Aims Considering recent revisions in the nomenclature for fatty liver disease, alongside limited data on sex‐specific differences in its cardiovascular/mortality outcomes, this study aims to investigate the prevalence and impact of metabolic‐associated fatty liver disease (MAFLD) on cardiovascular disease (CVD) and mortality in men and women over a 12‐year follow‐up period. Methods In this large population‐based cohort study, 7101 individuals aged ≥ 30 were enrolled. The prevalence of MAFLD was investigated in both genders. After excluding individuals with a history of previous CVD, 6331 participants were followed up for CVD and mortality over 12 years. Steatosis was defined as fatty liver index (FLI) ≥ 60. Multivariate‐adjusted hazard ratios (HRs) were calculated for CVD and mortality. Results The prevalence of MAFLD was 43.2%, higher in men (46.5%) than women (40.6%). Men with MAFLD (47.7 ± 12.1) were younger than women (52.2 ± 11.1). In the 12‐year follow‐up of 6331 individuals, multivariable‐adjusted CVD HRs for MAFLD were 1.36 (1.10–1.67) in men and 1.48 (1.16–1.88) in women. Adjusted mortality HRs were 1.17 (0.86–1.59) and 1.38 (1.00–1.91) in men and women, respectively. Among patients with MAFLD, a subgroup with diabetes faced the highest hazard for CVD and mortality. Conclusion This study found that MAFLD is more common in men at a younger age. Despite the higher prevalence in men, women with MAFLD face a greater risk of cardiovascular events and mortality. Findings highlight the importance of gender‐specific considerations in primary prevention programmes for MAFLD‐related cardiovascular disease and mortality. |
| format | Article |
| id | doaj-art-abb3bd2d7b524d32ac9b8d2b9845fa52 |
| institution | Kabale University |
| issn | 2398-9238 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | Endocrinology, Diabetes & Metabolism |
| spelling | doaj-art-abb3bd2d7b524d32ac9b8d2b9845fa522025-08-20T03:48:15ZengWileyEndocrinology, Diabetes & Metabolism2398-92382025-05-0183n/an/a10.1002/edm2.70035Sex‐Specific Impact of Metabolic Dysfunction‐Associated Fatty Liver Disease on Incident Cardiovascular Diseases and MortalityMahsa Abbaszadeh0Farhad Hosseinpanah1Maryam Tohidi2Sahar Karimpour Reyhan3Maryam Mahdavi4Majid Valizadeh5Endocrinology and Metabolism Research Center Imam Khomeini Hospital Complex, Tehran University of Medical Sciences Tehran IranObesity Research Center Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Science Tehran IranPrevention of Metabolic Disorders Research Center Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences Tehran IranEndocrinology and Metabolism Research Center Imam Khomeini Hospital Complex, Tehran University of Medical Sciences Tehran IranObesity Research Center Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Science Tehran IranObesity Research Center Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Science Tehran IranABSTRACT Background and Aims Considering recent revisions in the nomenclature for fatty liver disease, alongside limited data on sex‐specific differences in its cardiovascular/mortality outcomes, this study aims to investigate the prevalence and impact of metabolic‐associated fatty liver disease (MAFLD) on cardiovascular disease (CVD) and mortality in men and women over a 12‐year follow‐up period. Methods In this large population‐based cohort study, 7101 individuals aged ≥ 30 were enrolled. The prevalence of MAFLD was investigated in both genders. After excluding individuals with a history of previous CVD, 6331 participants were followed up for CVD and mortality over 12 years. Steatosis was defined as fatty liver index (FLI) ≥ 60. Multivariate‐adjusted hazard ratios (HRs) were calculated for CVD and mortality. Results The prevalence of MAFLD was 43.2%, higher in men (46.5%) than women (40.6%). Men with MAFLD (47.7 ± 12.1) were younger than women (52.2 ± 11.1). In the 12‐year follow‐up of 6331 individuals, multivariable‐adjusted CVD HRs for MAFLD were 1.36 (1.10–1.67) in men and 1.48 (1.16–1.88) in women. Adjusted mortality HRs were 1.17 (0.86–1.59) and 1.38 (1.00–1.91) in men and women, respectively. Among patients with MAFLD, a subgroup with diabetes faced the highest hazard for CVD and mortality. Conclusion This study found that MAFLD is more common in men at a younger age. Despite the higher prevalence in men, women with MAFLD face a greater risk of cardiovascular events and mortality. Findings highlight the importance of gender‐specific considerations in primary prevention programmes for MAFLD‐related cardiovascular disease and mortality.https://doi.org/10.1002/edm2.70035cardiovascular diseasemetabolic dysfunction‐associated fatty liver diseasesmortalitynon‐alcoholic fatty liver disease |
| spellingShingle | Mahsa Abbaszadeh Farhad Hosseinpanah Maryam Tohidi Sahar Karimpour Reyhan Maryam Mahdavi Majid Valizadeh Sex‐Specific Impact of Metabolic Dysfunction‐Associated Fatty Liver Disease on Incident Cardiovascular Diseases and Mortality Endocrinology, Diabetes & Metabolism cardiovascular disease metabolic dysfunction‐associated fatty liver diseases mortality non‐alcoholic fatty liver disease |
| title | Sex‐Specific Impact of Metabolic Dysfunction‐Associated Fatty Liver Disease on Incident Cardiovascular Diseases and Mortality |
| title_full | Sex‐Specific Impact of Metabolic Dysfunction‐Associated Fatty Liver Disease on Incident Cardiovascular Diseases and Mortality |
| title_fullStr | Sex‐Specific Impact of Metabolic Dysfunction‐Associated Fatty Liver Disease on Incident Cardiovascular Diseases and Mortality |
| title_full_unstemmed | Sex‐Specific Impact of Metabolic Dysfunction‐Associated Fatty Liver Disease on Incident Cardiovascular Diseases and Mortality |
| title_short | Sex‐Specific Impact of Metabolic Dysfunction‐Associated Fatty Liver Disease on Incident Cardiovascular Diseases and Mortality |
| title_sort | sex specific impact of metabolic dysfunction associated fatty liver disease on incident cardiovascular diseases and mortality |
| topic | cardiovascular disease metabolic dysfunction‐associated fatty liver diseases mortality non‐alcoholic fatty liver disease |
| url | https://doi.org/10.1002/edm2.70035 |
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