Anti-inflammatory effect of fluvastatin on polarized macrophages and its dependence on the mevalonate pathway

Anti-inflammatory effect of fluvastatin on polarized macrophages and its dependence on the mevalonate pathway

Abstract The study focuses on the effects of fluvastatin on immunomarkers of the M1 and M2 macrophages and its direct role in macrophage (M0) polarization. Moreover, it investigates the dependency of immunomodulatory properties of fluvastatin on the mevalonate pathway. Macrophages (M0, M1, M2), diff...

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Bibliographic Details
Main Authors: Barbora Muffova, Sona Kauerova, Karel Paukner, Hana Bartuskova, Rudolf Poledne, Ivana Kralova Lesna
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Scientific Reports
Subjects:
Fluvastatin
Macrophages
Polarization
Inflammation
Mevalonate pathway
Online Access:https://doi.org/10.1038/s41598-025-02418-9
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