Cardiometabolic Index as a predictor of mortality in metabolic Dysfunction-Associated Steatotic Liver Disease
Abstract Background Cardiometabolic Index (CMI) is positively correlated with liver fibrosis in patients with Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), but its association with mortality risk in MASLD patients remains unclear. Methods This study utilized data from NHANES III...
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BMC
2025-07-01
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| Series: | BMC Gastroenterology |
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| Online Access: | https://doi.org/10.1186/s12876-025-04127-z |
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| author | Yang Yang Cheng Zeng Zhiqiang Jin Yi Huang Huabao Liu |
| author_facet | Yang Yang Cheng Zeng Zhiqiang Jin Yi Huang Huabao Liu |
| author_sort | Yang Yang |
| collection | DOAJ |
| description | Abstract Background Cardiometabolic Index (CMI) is positively correlated with liver fibrosis in patients with Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), but its association with mortality risk in MASLD patients remains unclear. Methods This study utilized data from NHANES III and linked it with the mortality database up to December 31, 2019. Cox regression analysis was used to examine the relationship between CMI and mortality rates. Linear regression analysis was conducted to explore the correlation between CMI and the TyG index, and mediation analysis was performed to investigate the potential mechanisms underlying the association between CMI and mortality. Results The study included 2,260 MASLD patients with a median age of 51 years and a median CMI of 2.5. In the fully adjusted Cox regression model, CMI was positively associated with all-cause mortality (per 1-SD increase, HR = 1.04, 95% CI = 1.00-1.08) and other-cause mortality rates (per 1-SD increase, HR = 1.25, 95% CI = 1.12–1.40), but not with cardiovascular or cancer-related mortality. Mediation analysis indicated that the TyG index mediated 16.6% of the association between CMI and all-cause mortality. Conclusion CMI in MASLD patients is associated with an increased risk of all-cause and other-cause mortality. |
| format | Article |
| id | doaj-art-aba246289d114c03b482f94fe1b9b46d |
| institution | Kabale University |
| issn | 1471-230X |
| language | English |
| publishDate | 2025-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Gastroenterology |
| spelling | doaj-art-aba246289d114c03b482f94fe1b9b46d2025-08-20T03:45:52ZengBMCBMC Gastroenterology1471-230X2025-07-0125111210.1186/s12876-025-04127-zCardiometabolic Index as a predictor of mortality in metabolic Dysfunction-Associated Steatotic Liver DiseaseYang Yang0Cheng Zeng1Zhiqiang Jin2Yi Huang3Huabao Liu4Chongqing Traditional Chinese Medicine HospitalDepartment of Infectious Diseases, Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, the Second Affiliated Hospital, Chongqing Medical UniversityDepartment of Infectious Diseases, Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, the Second Affiliated Hospital, Chongqing Medical UniversityChongqing Traditional Chinese Medicine HospitalChongqing Traditional Chinese Medicine HospitalAbstract Background Cardiometabolic Index (CMI) is positively correlated with liver fibrosis in patients with Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), but its association with mortality risk in MASLD patients remains unclear. Methods This study utilized data from NHANES III and linked it with the mortality database up to December 31, 2019. Cox regression analysis was used to examine the relationship between CMI and mortality rates. Linear regression analysis was conducted to explore the correlation between CMI and the TyG index, and mediation analysis was performed to investigate the potential mechanisms underlying the association between CMI and mortality. Results The study included 2,260 MASLD patients with a median age of 51 years and a median CMI of 2.5. In the fully adjusted Cox regression model, CMI was positively associated with all-cause mortality (per 1-SD increase, HR = 1.04, 95% CI = 1.00-1.08) and other-cause mortality rates (per 1-SD increase, HR = 1.25, 95% CI = 1.12–1.40), but not with cardiovascular or cancer-related mortality. Mediation analysis indicated that the TyG index mediated 16.6% of the association between CMI and all-cause mortality. Conclusion CMI in MASLD patients is associated with an increased risk of all-cause and other-cause mortality.https://doi.org/10.1186/s12876-025-04127-zCardiometabolic indexMASLDMortalityTriglyceride-glucose indexNHANES |
| spellingShingle | Yang Yang Cheng Zeng Zhiqiang Jin Yi Huang Huabao Liu Cardiometabolic Index as a predictor of mortality in metabolic Dysfunction-Associated Steatotic Liver Disease BMC Gastroenterology Cardiometabolic index MASLD Mortality Triglyceride-glucose index NHANES |
| title | Cardiometabolic Index as a predictor of mortality in metabolic Dysfunction-Associated Steatotic Liver Disease |
| title_full | Cardiometabolic Index as a predictor of mortality in metabolic Dysfunction-Associated Steatotic Liver Disease |
| title_fullStr | Cardiometabolic Index as a predictor of mortality in metabolic Dysfunction-Associated Steatotic Liver Disease |
| title_full_unstemmed | Cardiometabolic Index as a predictor of mortality in metabolic Dysfunction-Associated Steatotic Liver Disease |
| title_short | Cardiometabolic Index as a predictor of mortality in metabolic Dysfunction-Associated Steatotic Liver Disease |
| title_sort | cardiometabolic index as a predictor of mortality in metabolic dysfunction associated steatotic liver disease |
| topic | Cardiometabolic index MASLD Mortality Triglyceride-glucose index NHANES |
| url | https://doi.org/10.1186/s12876-025-04127-z |
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