Neuropeptide Y mRNA expression in the aging inferior colliculus of fischer brown norway rats

Neuropeptide Y mRNA expression in the aging inferior colliculus of fischer brown norway rats

IntroductionA major contributor to age-related hearing loss is the decline of GABAergic inhibition, particularly in the inferior colliculus (IC), which is the midbrain hub of the central auditory system. The initial loss of inhibition is thought to be a compensatory mechanism in response to decrease...

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Main Authors: Laila S. Almassri, Kristen M. Crane, Sean R. Hergenrother, Gurveer Singh, Gillian L. Barach, Melina C. Iafrate, Joshua C. Harris, Nick Tokar, Andrew P. Ohl, Jesse W. Young, Jeffrey G. Mellott
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Aging Neuroscience
Subjects:
inferior colliculus
NPY
smFISH
NPY mRNA
GAD1 mRNA
aging
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2025.1626021/full
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