Comparative efficacy of 2% minoxidil alone against combination of 2% minoxidil and low-level laser therapy in female pattern hair loss–A randomized controlled trial in Chinese females
Objectives: To investigate the effectiveness and safety of combination of 655 nm low level laser helmet device with topical 2 % minoxidil solution at FPHL in Chinese population. Materials and methods: Randomized, parallel, controlled, single-blind clinical trial was conducted. FPHL subjects were ran...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-02-01
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| Series: | Photodiagnosis and Photodynamic Therapy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S157210002400005X |
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| author | Xianhong Yang Rui Qiao Wei Cheng Xuemei Lan Yufen Li Yiqun Jiang |
| author_facet | Xianhong Yang Rui Qiao Wei Cheng Xuemei Lan Yufen Li Yiqun Jiang |
| author_sort | Xianhong Yang |
| collection | DOAJ |
| description | Objectives: To investigate the effectiveness and safety of combination of 655 nm low level laser helmet device with topical 2 % minoxidil solution at FPHL in Chinese population. Materials and methods: Randomized, parallel, controlled, single-blind clinical trial was conducted. FPHL subjects were randomly allocated into 2 % minoxidil group and combination group. The 2 % minoxidil group received 1 ml topical 2 % minoxidil solution twice daily for 24 weeks. The combination group received 1 ml topical 2 % minoxidil solution twice daily together with 20 min 655 nm low-level laser helmet once every other day for 24 weeks. Hair parameters in two scalp areas including midscalp and vertex were evaluated at baseline, 12th week and 24th week. Results: In midscalp area, the combination group showed a lower increase in intermediate hair percentage than 2 % minoxidil group, which was statistically significant. Besides, the combination group had statistically significant increase than 2 % minoxidil group in mean hair diameter. Reported relative adverse events included slightly hair loss (27.8 %), desquamation (19.0 %), pruritus (15.2 %), seborrhea (2.5 %) and hypertrichosis (2.5 %). Conclusion: In our trial, LLLT was demonstrated as a useful supplementary treatment for FPHL and the combination with 2 % minoxidil accomplished better improvement in intermediate hair enlargement and hair diameter of midscalp for FPHL |
| format | Article |
| id | doaj-art-ab9c2d4adea6419bbefb636262067751 |
| institution | OA Journals |
| issn | 1572-1000 |
| language | English |
| publishDate | 2024-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Photodiagnosis and Photodynamic Therapy |
| spelling | doaj-art-ab9c2d4adea6419bbefb6362620677512025-08-20T02:39:02ZengElsevierPhotodiagnosis and Photodynamic Therapy1572-10002024-02-014510396610.1016/j.pdpdt.2024.103966Comparative efficacy of 2% minoxidil alone against combination of 2% minoxidil and low-level laser therapy in female pattern hair loss–A randomized controlled trial in Chinese femalesXianhong Yang0Rui Qiao1Wei Cheng2Xuemei Lan3Yufen Li4Yiqun Jiang5Department of Dermatopathology, Hospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing 210042, China; Center for Plastic & Reconstructive Surgery, Department of Dermatology, Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou Medical College), Hangzhou 310014, ChinaDepartment of Dermatopathology, Hospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing 210042, ChinaDepartment of Dermatopathology, Hospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing 210042, ChinaDepartment of Dermatopathology, Hospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing 210042, ChinaDepartment of Dermatopathology, Hospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing 210042, ChinaDepartment of Dermatopathology, Hospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing 210042, China; Corresponding author.Objectives: To investigate the effectiveness and safety of combination of 655 nm low level laser helmet device with topical 2 % minoxidil solution at FPHL in Chinese population. Materials and methods: Randomized, parallel, controlled, single-blind clinical trial was conducted. FPHL subjects were randomly allocated into 2 % minoxidil group and combination group. The 2 % minoxidil group received 1 ml topical 2 % minoxidil solution twice daily for 24 weeks. The combination group received 1 ml topical 2 % minoxidil solution twice daily together with 20 min 655 nm low-level laser helmet once every other day for 24 weeks. Hair parameters in two scalp areas including midscalp and vertex were evaluated at baseline, 12th week and 24th week. Results: In midscalp area, the combination group showed a lower increase in intermediate hair percentage than 2 % minoxidil group, which was statistically significant. Besides, the combination group had statistically significant increase than 2 % minoxidil group in mean hair diameter. Reported relative adverse events included slightly hair loss (27.8 %), desquamation (19.0 %), pruritus (15.2 %), seborrhea (2.5 %) and hypertrichosis (2.5 %). Conclusion: In our trial, LLLT was demonstrated as a useful supplementary treatment for FPHL and the combination with 2 % minoxidil accomplished better improvement in intermediate hair enlargement and hair diameter of midscalp for FPHLhttp://www.sciencedirect.com/science/article/pii/S157210002400005XFemale pattern hair lossLow-level laser therapytreatmentClinical trial |
| spellingShingle | Xianhong Yang Rui Qiao Wei Cheng Xuemei Lan Yufen Li Yiqun Jiang Comparative efficacy of 2% minoxidil alone against combination of 2% minoxidil and low-level laser therapy in female pattern hair loss–A randomized controlled trial in Chinese females Photodiagnosis and Photodynamic Therapy Female pattern hair loss Low-level laser therapy treatment Clinical trial |
| title | Comparative efficacy of 2% minoxidil alone against combination of 2% minoxidil and low-level laser therapy in female pattern hair loss–A randomized controlled trial in Chinese females |
| title_full | Comparative efficacy of 2% minoxidil alone against combination of 2% minoxidil and low-level laser therapy in female pattern hair loss–A randomized controlled trial in Chinese females |
| title_fullStr | Comparative efficacy of 2% minoxidil alone against combination of 2% minoxidil and low-level laser therapy in female pattern hair loss–A randomized controlled trial in Chinese females |
| title_full_unstemmed | Comparative efficacy of 2% minoxidil alone against combination of 2% minoxidil and low-level laser therapy in female pattern hair loss–A randomized controlled trial in Chinese females |
| title_short | Comparative efficacy of 2% minoxidil alone against combination of 2% minoxidil and low-level laser therapy in female pattern hair loss–A randomized controlled trial in Chinese females |
| title_sort | comparative efficacy of 2 minoxidil alone against combination of 2 minoxidil and low level laser therapy in female pattern hair loss a randomized controlled trial in chinese females |
| topic | Female pattern hair loss Low-level laser therapy treatment Clinical trial |
| url | http://www.sciencedirect.com/science/article/pii/S157210002400005X |
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