Discovery and validation of biomarkers for Parkinson’s disease from human cerebrospinal fluid using mass spectrometry-based proteomics analysisResearch in context

Discovery and validation of biomarkers for Parkinson’s disease from human cerebrospinal fluid using mass spectrometry-based proteomics analysisResearch in context

Summary: Background: Proteomic biomarkers for Parkinson’s disease (PD) are critical for identifying new targets for disease-modifying therapies and expanding our understanding of disease pathophysiology. Methods: Deep proteome analysis of a cerebrospinal fluid (CSF) cohort (40 PD, 40 controls) coup...

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Bibliographic Details
Main Authors: Sungtaek Oh, Jaehun Jung, Jinhyeok Kim, Yura Jang, Catherine C. Bakker, Alexander Y. Pantelyat, Zhen Zhang, Ted M. Dawson, Chan Hyun Na, Liana S. Rosenthal
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:EBioMedicine
Subjects:
Parkinson’s disease
Biomarkers
Proteomics
Cerebrospinal fluids
Mass spectrometry
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396425002889
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