Effect of spironolactone on transmitral diastolic blood flow and course of chronic heart failure with preserved left ventricular ejection fraction
Existing recommendations on the mineralocorticoid/aldosterone receptor antagonists have been developed only for patients with systolic heart failure, and all outcome trials performed in patients with preserved ejection fraction failed to improve prognosis in this condition. Аim. To examine the ef...
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| Format: | Article |
| Language: | English |
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Zaporizhzhia State Medical and Pharmaceutical University
2015-10-01
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| Series: | Zaporožskij Medicinskij Žurnal |
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| Online Access: | http://zmj.zsmu.edu.ua/article/view/53746/50303 |
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| author | V. A. Vasylenko |
| author_facet | V. A. Vasylenko |
| author_sort | V. A. Vasylenko |
| collection | DOAJ |
| description | Existing recommendations on the mineralocorticoid/aldosterone receptor antagonists have been developed only for patients with systolic heart failure, and all outcome trials performed in patients with preserved ejection fraction failed to improve prognosis in this condition.
Аim. To examine the effectiveness of spironolactone therapy in elderly patients with chronic heart failure NYHA I–II with preserved left ventricular ejection fraction.
Methods and results. Peculiarities of transmitral diastolic blood flow was studied with Doppler echocardiography. 6-min walk test and NT-proBNP was performed for the assessment of clinical course improvement in such patients.
Conclusion. It was found that spironolactone therapy improves mitral diastolic blood flow, reduces concentration of NT-proBNP, which correlates with improved clinical course of heart failure. |
| format | Article |
| id | doaj-art-ab9519ed99b74047a20ceee76688a91f |
| institution | OA Journals |
| issn | 2306-4145 2310-1210 |
| language | English |
| publishDate | 2015-10-01 |
| publisher | Zaporizhzhia State Medical and Pharmaceutical University |
| record_format | Article |
| series | Zaporožskij Medicinskij Žurnal |
| spelling | doaj-art-ab9519ed99b74047a20ceee76688a91f2025-08-20T02:20:12ZengZaporizhzhia State Medical and Pharmaceutical UniversityZaporožskij Medicinskij Žurnal2306-41452310-12102015-10-015912http://dx.doi.org/10.14739/2310-1210.2015.5.53746Effect of spironolactone on transmitral diastolic blood flow and course of chronic heart failure with preserved left ventricular ejection fractionV. A. VasylenkoExisting recommendations on the mineralocorticoid/aldosterone receptor antagonists have been developed only for patients with systolic heart failure, and all outcome trials performed in patients with preserved ejection fraction failed to improve prognosis in this condition. Аim. To examine the effectiveness of spironolactone therapy in elderly patients with chronic heart failure NYHA I–II with preserved left ventricular ejection fraction. Methods and results. Peculiarities of transmitral diastolic blood flow was studied with Doppler echocardiography. 6-min walk test and NT-proBNP was performed for the assessment of clinical course improvement in such patients. Conclusion. It was found that spironolactone therapy improves mitral diastolic blood flow, reduces concentration of NT-proBNP, which correlates with improved clinical course of heart failure.http://zmj.zsmu.edu.ua/article/view/53746/50303Congestive Heart FailureSpironolactoneNT-proBNP |
| spellingShingle | V. A. Vasylenko Effect of spironolactone on transmitral diastolic blood flow and course of chronic heart failure with preserved left ventricular ejection fraction Zaporožskij Medicinskij Žurnal Congestive Heart Failure Spironolactone NT-proBNP |
| title | Effect of spironolactone on transmitral diastolic blood flow and course of chronic heart failure with preserved left ventricular ejection fraction |
| title_full | Effect of spironolactone on transmitral diastolic blood flow and course of chronic heart failure with preserved left ventricular ejection fraction |
| title_fullStr | Effect of spironolactone on transmitral diastolic blood flow and course of chronic heart failure with preserved left ventricular ejection fraction |
| title_full_unstemmed | Effect of spironolactone on transmitral diastolic blood flow and course of chronic heart failure with preserved left ventricular ejection fraction |
| title_short | Effect of spironolactone on transmitral diastolic blood flow and course of chronic heart failure with preserved left ventricular ejection fraction |
| title_sort | effect of spironolactone on transmitral diastolic blood flow and course of chronic heart failure with preserved left ventricular ejection fraction |
| topic | Congestive Heart Failure Spironolactone NT-proBNP |
| url | http://zmj.zsmu.edu.ua/article/view/53746/50303 |
| work_keys_str_mv | AT vavasylenko effectofspironolactoneontransmitraldiastolicbloodflowandcourseofchronicheartfailurewithpreservedleftventricularejectionfraction |