1,4‐Dioxane Induces Epithelial‐Mesenchymal Transition and Carcinogenesis in an Nrf2‐Dependent Manner

1,4‐Dioxane Induces Epithelial‐Mesenchymal Transition and Carcinogenesis in an Nrf2‐Dependent Manner

ABSTRACT The carcinogenic potential of the environmental pollutant 1,4‐dioxane (1,4‐D) in humans is not yet fully understood or recognised. In this study, we provide evidence that 1,4‐D acts as a carcinogen in human epithelial cells. Using the human bronchial epithelial cell line BEAS‐2B, with or wi...

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Main Authors: Ziwei Wang, Chitra Thakur, Zhuoyue Bi, Yiran Qiu, Wenxuan Zhang, Haoyan Ji, Arjun K. Venkatesan, Sashank Cherukuri, Ke Jian Liu, John D. Haley, Xinwei Mao, Jaymie Meliker, Fei Chen
Format: Article
Language:English
Published: Wiley 2025-05-01
Series:Journal of Extracellular Vesicles
Subjects:
1,4‐dioxane
EMT
EV biogenesis
Nrf2
SDC4
Online Access:https://doi.org/10.1002/jev2.70072
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