Neurotrophic Keratitis in Locally Advanced Nasopharyngeal Carcinoma
Nasopharyngeal carcinoma is a locally invasive malignant tumor that invades the orbit frequently. We came across a 65-year-old man with locally advanced nasopharyngeal carcinoma on chemotherapy with orbital invasion causing total ophthalmoplegia, loss of corneal sensations, and ptosis. He also had a...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Light House Polyclinic Mangalore
2025-04-01
|
| Series: | Online Journal of Health & Allied Sciences |
| Subjects: | |
| Online Access: | https://www.ojhas.org/issue93/2025-1-10.html |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850183038146707456 |
|---|---|
| author | Madhurima A Nayak Sunayana Bhat Sripathi Kamath B Akshata Charlotte |
| author_facet | Madhurima A Nayak Sunayana Bhat Sripathi Kamath B Akshata Charlotte |
| author_sort | Madhurima A Nayak |
| collection | DOAJ |
| description | Nasopharyngeal carcinoma is a locally invasive malignant tumor that invades the orbit frequently. We came across a 65-year-old man with locally advanced nasopharyngeal carcinoma on chemotherapy with orbital invasion causing total ophthalmoplegia, loss of corneal sensations, and ptosis. He also had a central neurotrophic keratitis with hypopyon. Based on these findings, a diagnosis of left-sided superior orbital fissure syndrome with neurotrophic keratitis was made. CT scan of the head revealed a soft-tissue mass abutting the superior aspect of the orbit and cavernous sinus and tumor recurrence was confirmed. We started the patient on topical fortified antibiotics and Atropine after placing a bandage contact lens. He was advised palliative radiotherapy by the medical oncologist. In two months, there was marked improvement in ocular motility, ptosis, and redness. The ulcer had healed by the formation of a central macular opacity. Corneal sensations had returned. This case exemplifies the reversible nature of superior orbital fissure syndrome and associated corneal anesthesia. As the tumor is radiosensitive, the mass effect of the tumor was reduced leading to the resolution of ophthalmoplegia and healing of the ulcer. |
| format | Article |
| id | doaj-art-ab824c41f41a4e79ab09634918ceed11 |
| institution | OA Journals |
| issn | 0972-5997 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Light House Polyclinic Mangalore |
| record_format | Article |
| series | Online Journal of Health & Allied Sciences |
| spelling | doaj-art-ab824c41f41a4e79ab09634918ceed112025-08-20T02:17:28ZengLight House Polyclinic MangaloreOnline Journal of Health & Allied Sciences0972-59972025-04-01241Neurotrophic Keratitis in Locally Advanced Nasopharyngeal CarcinomaMadhurima A Nayak0Sunayana Bhat1Sripathi Kamath B2Akshata Charlotte3Assistant Professor, Department of Ophthalmology, Father Muller Medical College, Mangaluru, India.Professor, Department of Ophthalmology, Father Muller Medical College, Mangaluru, India.Associate Professor, Department of Ophthalmology, Father Muller Medical College, Mangaluru, India.Assistant Professor, Department of Ophthalmology, Father Muller Medical College, Mangaluru, India.Nasopharyngeal carcinoma is a locally invasive malignant tumor that invades the orbit frequently. We came across a 65-year-old man with locally advanced nasopharyngeal carcinoma on chemotherapy with orbital invasion causing total ophthalmoplegia, loss of corneal sensations, and ptosis. He also had a central neurotrophic keratitis with hypopyon. Based on these findings, a diagnosis of left-sided superior orbital fissure syndrome with neurotrophic keratitis was made. CT scan of the head revealed a soft-tissue mass abutting the superior aspect of the orbit and cavernous sinus and tumor recurrence was confirmed. We started the patient on topical fortified antibiotics and Atropine after placing a bandage contact lens. He was advised palliative radiotherapy by the medical oncologist. In two months, there was marked improvement in ocular motility, ptosis, and redness. The ulcer had healed by the formation of a central macular opacity. Corneal sensations had returned. This case exemplifies the reversible nature of superior orbital fissure syndrome and associated corneal anesthesia. As the tumor is radiosensitive, the mass effect of the tumor was reduced leading to the resolution of ophthalmoplegia and healing of the ulcer.https://www.ojhas.org/issue93/2025-1-10.htmlneurotrophic keratitisnasopharyngeal carcinomasuperior orbital fissure syndrome |
| spellingShingle | Madhurima A Nayak Sunayana Bhat Sripathi Kamath B Akshata Charlotte Neurotrophic Keratitis in Locally Advanced Nasopharyngeal Carcinoma Online Journal of Health & Allied Sciences neurotrophic keratitis nasopharyngeal carcinoma superior orbital fissure syndrome |
| title | Neurotrophic Keratitis in Locally Advanced Nasopharyngeal Carcinoma |
| title_full | Neurotrophic Keratitis in Locally Advanced Nasopharyngeal Carcinoma |
| title_fullStr | Neurotrophic Keratitis in Locally Advanced Nasopharyngeal Carcinoma |
| title_full_unstemmed | Neurotrophic Keratitis in Locally Advanced Nasopharyngeal Carcinoma |
| title_short | Neurotrophic Keratitis in Locally Advanced Nasopharyngeal Carcinoma |
| title_sort | neurotrophic keratitis in locally advanced nasopharyngeal carcinoma |
| topic | neurotrophic keratitis nasopharyngeal carcinoma superior orbital fissure syndrome |
| url | https://www.ojhas.org/issue93/2025-1-10.html |
| work_keys_str_mv | AT madhurimaanayak neurotrophickeratitisinlocallyadvancednasopharyngealcarcinoma AT sunayanabhat neurotrophickeratitisinlocallyadvancednasopharyngealcarcinoma AT sripathikamathb neurotrophickeratitisinlocallyadvancednasopharyngealcarcinoma AT akshatacharlotte neurotrophickeratitisinlocallyadvancednasopharyngealcarcinoma |