Exploring rice varietal effects on triglyceride/high density lipoprotein ratio in hyperlipidemia-induced wistar rats
Background: Excessive intake of white rice has been associated with elevated triglyceride (TG) levels and decreased high density lipoprotein (HDL) cholesterol concentrations. Conversely, black and red rice varieties have demonstrated favorable impacts on lipid metabolism. However, despite these bene...
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Diponegoro University
2025-06-01
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| Series: | Jurnal Gizi Indonesia: The Indonesian Journal of Nutrition |
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| Online Access: | https://ejournal.undip.ac.id/index.php/jgi/article/view/63269 |
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| author | Yusie Rosmalinda Etika Ratna Noer Mohammad Sulchan Sya’bani Isnaen Khikmaturrohman Martha Ardiaria Firdaus Shadiqa Marsa Via Anugrah Henny Hartanti Sandi Wijayanti Binar Panunggal |
| author_facet | Yusie Rosmalinda Etika Ratna Noer Mohammad Sulchan Sya’bani Isnaen Khikmaturrohman Martha Ardiaria Firdaus Shadiqa Marsa Via Anugrah Henny Hartanti Sandi Wijayanti Binar Panunggal |
| author_sort | Yusie Rosmalinda |
| collection | DOAJ |
| description | Background: Excessive intake of white rice has been associated with elevated triglyceride (TG) levels and decreased high density lipoprotein (HDL) cholesterol concentrations. Conversely, black and red rice varieties have demonstrated favorable impacts on lipid metabolism. However, despite these benefits, their palatability and texture are often met with aversion by consumers. Consequently, it is imperative to investigate rice blends that are both well-received by individuals and exhibit pronounced efficacy in reducing the TG/HDL ratio.
Objective: To investigate the differential effects on the TG/HDL ratio in rats administered different combinations of white, red, and black rice.
Methods: This research follows a true experimental design incorporating pre- and post-tests with a control group. Thirty rats were initially fed a hyperlipidemic diet for 14 days. Subsequently, the rats were subjected to interventions involving different rice combinations for a duration of 28 days. These combinations included K(+) (positive control), P1 (100% white rice), P2 (21 g red and 4 g white rice), P3 (16 g black and 4 g white rice), and P4 (8 g black, 8 g red, and 4 g white rice). Triglyceride and HDL levels were quantified using the GPO-PAP and CHOD-PAP methods, respectively. Statistical analysis was performed utilizing ANOVA tests followed by LSD post-hoc tests for comparison.
Results: Triglycerides decrease in P4 (-51.04±0.72) was the highest, followed by P3 (47.18±0.51), P2 (-34.60±1.07), P1 (-17.03±1, 06). Cholesterol HDL increase in P4 (49.36±1.68) was the highest, followed by P3 (42.71±0.41), P2 (38.09±0.76), P1 (30.64±0.90). The TG/HDL ratio in P1, P2, P3, and P4 were 0.21±0.092, -2.12±0.164, -2.45±0.123, -2.82±0.148, -3.18±0.371, respectively. The rice combination intervention had a significant decreased on the TG/HDL ratio (p=0.000).
Conclusion: The intervention involving rice combinations resulted in a greater reduction in the TG/HDL ratio compared to the consumption of white rice alone. Among the various combinations tested, the combination of white, red, and black rice demonstrated the most significant reduction in the triglyceride to HDL-cholesterol (TG/HDL) ratio. |
| format | Article |
| id | doaj-art-ab800cd635ee4e3c93233bc2c4f12704 |
| institution | Kabale University |
| issn | 2338-3119 |
| language | Indonesian |
| publishDate | 2025-06-01 |
| publisher | Diponegoro University |
| record_format | Article |
| series | Jurnal Gizi Indonesia: The Indonesian Journal of Nutrition |
| spelling | doaj-art-ab800cd635ee4e3c93233bc2c4f127042025-08-20T03:29:24ZindDiponegoro UniversityJurnal Gizi Indonesia: The Indonesian Journal of Nutrition2338-31192025-06-0113217018110.14710/jgi.13.2.170-18125938Exploring rice varietal effects on triglyceride/high density lipoprotein ratio in hyperlipidemia-induced wistar ratsYusie Rosmalinda0Etika Ratna Noer1https://orcid.org/0000-0002-1555-5944Mohammad Sulchan2Sya’bani Isnaen Khikmaturrohman3Martha Ardiaria4Firdaus Shadiqa Marsa5Via Anugrah Henny6Hartanti Sandi Wijayanti7https://orcid.org/0000-0002-7009-1011Binar Panunggal8https://orcid.org/0000-0002-7917-2010Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro, Semarang, Central Java, IndonesiaDepartment of Nutrition Science, Faculty of Medicine, Universitas Diponegoro, Semarang, Central Java, IndonesiaDepartment of Nutrition Science, Faculty of Medicine, Universitas Diponegoro, Semarang, Central Java, IndonesiaDepartment of Nutrition Science, Faculty of Medicine, Universitas Diponegoro, Semarang, Central Java, IndonesiaDepartment of Nutrition Science, Faculty of Medicine, Universitas Diponegoro, Semarang, Central Java, IndonesiaDepartment of Nutrition Science, Faculty of Medicine, Universitas Diponegoro, Semarang, Central Java, IndonesiaDepartment of Nutrition Science, Faculty of Medicine, Universitas Diponegoro, Semarang, Central Java, IndonesiaDepartment of Epidemiology and Preventive Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, JapanSchool of Nutrition and Health Sciences, Taipei Medical University, Taipei, TaiwanBackground: Excessive intake of white rice has been associated with elevated triglyceride (TG) levels and decreased high density lipoprotein (HDL) cholesterol concentrations. Conversely, black and red rice varieties have demonstrated favorable impacts on lipid metabolism. However, despite these benefits, their palatability and texture are often met with aversion by consumers. Consequently, it is imperative to investigate rice blends that are both well-received by individuals and exhibit pronounced efficacy in reducing the TG/HDL ratio. Objective: To investigate the differential effects on the TG/HDL ratio in rats administered different combinations of white, red, and black rice. Methods: This research follows a true experimental design incorporating pre- and post-tests with a control group. Thirty rats were initially fed a hyperlipidemic diet for 14 days. Subsequently, the rats were subjected to interventions involving different rice combinations for a duration of 28 days. These combinations included K(+) (positive control), P1 (100% white rice), P2 (21 g red and 4 g white rice), P3 (16 g black and 4 g white rice), and P4 (8 g black, 8 g red, and 4 g white rice). Triglyceride and HDL levels were quantified using the GPO-PAP and CHOD-PAP methods, respectively. Statistical analysis was performed utilizing ANOVA tests followed by LSD post-hoc tests for comparison. Results: Triglycerides decrease in P4 (-51.04±0.72) was the highest, followed by P3 (47.18±0.51), P2 (-34.60±1.07), P1 (-17.03±1, 06). Cholesterol HDL increase in P4 (49.36±1.68) was the highest, followed by P3 (42.71±0.41), P2 (38.09±0.76), P1 (30.64±0.90). The TG/HDL ratio in P1, P2, P3, and P4 were 0.21±0.092, -2.12±0.164, -2.45±0.123, -2.82±0.148, -3.18±0.371, respectively. The rice combination intervention had a significant decreased on the TG/HDL ratio (p=0.000). Conclusion: The intervention involving rice combinations resulted in a greater reduction in the TG/HDL ratio compared to the consumption of white rice alone. Among the various combinations tested, the combination of white, red, and black rice demonstrated the most significant reduction in the triglyceride to HDL-cholesterol (TG/HDL) ratio.https://ejournal.undip.ac.id/index.php/jgi/article/view/63269black ricehdlred ricetriglyceridewhite rice |
| spellingShingle | Yusie Rosmalinda Etika Ratna Noer Mohammad Sulchan Sya’bani Isnaen Khikmaturrohman Martha Ardiaria Firdaus Shadiqa Marsa Via Anugrah Henny Hartanti Sandi Wijayanti Binar Panunggal Exploring rice varietal effects on triglyceride/high density lipoprotein ratio in hyperlipidemia-induced wistar rats Jurnal Gizi Indonesia: The Indonesian Journal of Nutrition black rice hdl red rice triglyceride white rice |
| title | Exploring rice varietal effects on triglyceride/high density lipoprotein ratio in hyperlipidemia-induced wistar rats |
| title_full | Exploring rice varietal effects on triglyceride/high density lipoprotein ratio in hyperlipidemia-induced wistar rats |
| title_fullStr | Exploring rice varietal effects on triglyceride/high density lipoprotein ratio in hyperlipidemia-induced wistar rats |
| title_full_unstemmed | Exploring rice varietal effects on triglyceride/high density lipoprotein ratio in hyperlipidemia-induced wistar rats |
| title_short | Exploring rice varietal effects on triglyceride/high density lipoprotein ratio in hyperlipidemia-induced wistar rats |
| title_sort | exploring rice varietal effects on triglyceride high density lipoprotein ratio in hyperlipidemia induced wistar rats |
| topic | black rice hdl red rice triglyceride white rice |
| url | https://ejournal.undip.ac.id/index.php/jgi/article/view/63269 |
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