Effect of cyclosporin-A on the blood–retinal barrier permeability in streptozotocin-induced diabetes
Background: Our previous results showed that in retinas from streptozotocin (STZ)-induced diabetic rats there is an increased level of interleukin-1β (IL-1β ). This cytokine may be involved in the expression of the inducible isoform of the nitric oxide synthase (iNOS), with consequent synthesis of l...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2000-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1080/09629350020025764 |
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| _version_ | 1850171704477745152 |
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| author | Anália Carmo José G. Cunha-Vaz Arsélio P. Carvalho Maria Celeste Lopes |
| author_facet | Anália Carmo José G. Cunha-Vaz Arsélio P. Carvalho Maria Celeste Lopes |
| author_sort | Anália Carmo |
| collection | DOAJ |
| description | Background: Our previous results showed that in retinas from streptozotocin (STZ)-induced diabetic rats there is an increased level of interleukin-1β (IL-1β ). This cytokine may be involved in the expression of the inducible isoform of the nitric oxide synthase (iNOS), with consequent synthesis of large amounts of NO and
blood–retinal barrier (BRB) breakdown. |
| format | Article |
| id | doaj-art-ab7ef4c09137408492dd2b8906ff5da3 |
| institution | OA Journals |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2000-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-ab7ef4c09137408492dd2b8906ff5da32025-08-20T02:20:13ZengWileyMediators of Inflammation0962-93511466-18612000-01-019524324810.1080/09629350020025764Effect of cyclosporin-A on the blood–retinal barrier permeability in streptozotocin-induced diabetesAnália Carmo0José G. Cunha-Vaz1Arsélio P. Carvalho2Maria Celeste Lopes3Center of Ophthalmology, Institute for Biomedical Research on Light and Image, University of Coimbra, Coimbra, PortugalCenter of Ophthalmology, Institute for Biomedical Research on Light and Image, University of Coimbra, Coimbra, PortugalCenter for Neurosciences of Coimbra, Department of Zoology, University of Coimbra, Coimbra, PortugalCenter for Neurosciences of Coimbra, Department of Zoology, University of Coimbra, Coimbra, PortugalBackground: Our previous results showed that in retinas from streptozotocin (STZ)-induced diabetic rats there is an increased level of interleukin-1β (IL-1β ). This cytokine may be involved in the expression of the inducible isoform of the nitric oxide synthase (iNOS), with consequent synthesis of large amounts of NO and blood–retinal barrier (BRB) breakdown.http://dx.doi.org/10.1080/09629350020025764 |
| spellingShingle | Anália Carmo José G. Cunha-Vaz Arsélio P. Carvalho Maria Celeste Lopes Effect of cyclosporin-A on the blood–retinal barrier permeability in streptozotocin-induced diabetes Mediators of Inflammation |
| title | Effect of cyclosporin-A on the blood–retinal barrier permeability in streptozotocin-induced diabetes |
| title_full | Effect of cyclosporin-A on the blood–retinal barrier permeability in streptozotocin-induced diabetes |
| title_fullStr | Effect of cyclosporin-A on the blood–retinal barrier permeability in streptozotocin-induced diabetes |
| title_full_unstemmed | Effect of cyclosporin-A on the blood–retinal barrier permeability in streptozotocin-induced diabetes |
| title_short | Effect of cyclosporin-A on the blood–retinal barrier permeability in streptozotocin-induced diabetes |
| title_sort | effect of cyclosporin a on the blood retinal barrier permeability in streptozotocin induced diabetes |
| url | http://dx.doi.org/10.1080/09629350020025764 |
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