Noncanonical function of Pannexin1 promotes cellular senescence and renal fibrosis post-acute kidney injury

Noncanonical function of Pannexin1 promotes cellular senescence and renal fibrosis post-acute kidney injury

Abstract Acute kidney injury (AKI) can lead to chronic kidney disease (CKD), a transition driven by cellular senescence, a state of irreversible cell-cycle arrest. However, the molecular mechanisms promoting this pathological process remain unclear. Here we show that the channel protein Pannexin1 (P...

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Main Authors: Liuwei Huang, Yanting Shen, Xiaoling Pan, Jiaqi Li, Caizhen Li, Lixin Ruan, Sitan He, Lanlan Huang, Kangyi Liu, Xin Zhao, Jian Geng, Jie Guo, Fan Fan Hou, Jun Wang
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-63152-4
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