pH-Dependent Drug Delivery Systems for Ulcerative Colitis Treatment
Inflammatory bowel diseases (IBDs), such as ulcerative colitis (UC) or Crohn’s disease, are becoming a growing global problem due to the limitations of current treatments, which fail to address the needs of patients effectively. UC is characterized by the widespread inflammation of the mucosal linin...
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MDPI AG
2025-02-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/17/2/226 |
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| author | Yana Gvozdeva Radiana Staynova |
| author_facet | Yana Gvozdeva Radiana Staynova |
| author_sort | Yana Gvozdeva |
| collection | DOAJ |
| description | Inflammatory bowel diseases (IBDs), such as ulcerative colitis (UC) or Crohn’s disease, are becoming a growing global problem due to the limitations of current treatments, which fail to address the needs of patients effectively. UC is characterized by the widespread inflammation of the mucosal lining, affecting both the rectum and the entire length of the colon. Over the past forty years, traditional treatments for IBDs have primarily relied on anti-inflammatory drugs and immunosuppressive medications. Treatment could be more effective if drugs could be specifically targeted to act directly on the colon. Conventional drug delivery systems for IBDs encounter numerous challenges on their way to the colon, such as physiological barriers and disease severity. To address these issues, pH-dependent carriers have emerged as a promising advancement, offering a more effective and tolerable treatment for UC. These carriers enable localized, targeted action, reducing side effects and preventing the premature clearance of drugs from inflamed colon tissues. pH-responsive systems are a leading approach for targeted drug release in colitis treatment as they take advantage of the varying pH levels throughout the gastrointestinal tract (GIT). By incorporating pH-sensitive polymers, they ensure drug protection and controlled release in the lower GIT. This review will discuss the advantages and limitations of pH-dependent drug delivery systems for colon-targeted drug delivery. |
| format | Article |
| id | doaj-art-ab798878e5c349eea77e8ab9ba4f71e1 |
| institution | DOAJ |
| issn | 1999-4923 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | MDPI AG |
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| series | Pharmaceutics |
| spelling | doaj-art-ab798878e5c349eea77e8ab9ba4f71e12025-08-20T02:44:50ZengMDPI AGPharmaceutics1999-49232025-02-0117222610.3390/pharmaceutics17020226pH-Dependent Drug Delivery Systems for Ulcerative Colitis TreatmentYana Gvozdeva0Radiana Staynova1Department of Pharmaceutical Sciences, Faculty of Pharmacy, Medical University of Plovdiv, 4002 Plovdiv, BulgariaDepartment of Organisation and Economics of Pharmacy, Faculty of Pharmacy, Medical University of Plovdiv, 4002 Plovdiv, BulgariaInflammatory bowel diseases (IBDs), such as ulcerative colitis (UC) or Crohn’s disease, are becoming a growing global problem due to the limitations of current treatments, which fail to address the needs of patients effectively. UC is characterized by the widespread inflammation of the mucosal lining, affecting both the rectum and the entire length of the colon. Over the past forty years, traditional treatments for IBDs have primarily relied on anti-inflammatory drugs and immunosuppressive medications. Treatment could be more effective if drugs could be specifically targeted to act directly on the colon. Conventional drug delivery systems for IBDs encounter numerous challenges on their way to the colon, such as physiological barriers and disease severity. To address these issues, pH-dependent carriers have emerged as a promising advancement, offering a more effective and tolerable treatment for UC. These carriers enable localized, targeted action, reducing side effects and preventing the premature clearance of drugs from inflamed colon tissues. pH-responsive systems are a leading approach for targeted drug release in colitis treatment as they take advantage of the varying pH levels throughout the gastrointestinal tract (GIT). By incorporating pH-sensitive polymers, they ensure drug protection and controlled release in the lower GIT. This review will discuss the advantages and limitations of pH-dependent drug delivery systems for colon-targeted drug delivery.https://www.mdpi.com/1999-4923/17/2/226ulcerative colitispH-dependent drug delivery systemspH-responsive polymerspH-sensitive carriercolon-targeted drug delivery |
| spellingShingle | Yana Gvozdeva Radiana Staynova pH-Dependent Drug Delivery Systems for Ulcerative Colitis Treatment Pharmaceutics ulcerative colitis pH-dependent drug delivery systems pH-responsive polymers pH-sensitive carrier colon-targeted drug delivery |
| title | pH-Dependent Drug Delivery Systems for Ulcerative Colitis Treatment |
| title_full | pH-Dependent Drug Delivery Systems for Ulcerative Colitis Treatment |
| title_fullStr | pH-Dependent Drug Delivery Systems for Ulcerative Colitis Treatment |
| title_full_unstemmed | pH-Dependent Drug Delivery Systems for Ulcerative Colitis Treatment |
| title_short | pH-Dependent Drug Delivery Systems for Ulcerative Colitis Treatment |
| title_sort | ph dependent drug delivery systems for ulcerative colitis treatment |
| topic | ulcerative colitis pH-dependent drug delivery systems pH-responsive polymers pH-sensitive carrier colon-targeted drug delivery |
| url | https://www.mdpi.com/1999-4923/17/2/226 |
| work_keys_str_mv | AT yanagvozdeva phdependentdrugdeliverysystemsforulcerativecolitistreatment AT radianastaynova phdependentdrugdeliverysystemsforulcerativecolitistreatment |