Inhibition of PTPRS function does not affect the survival or regeneration of dopaminergic neurons but alters synaptic function in the nigrostriatal pathway

Inhibition of PTPRS function does not affect the survival or regeneration of dopaminergic neurons but alters synaptic function in the nigrostriatal pathway

Parkinson's Disease (PD) is characterized by midbrain dopaminergic (mDA) neuron degeneration in the ventral midbrain, contributing to debilitating motor symptoms. This study investigated whether Protein Tyrosine Phosphatase Receptor Sigma (PTPRS), a known inhibitor of axonal growth through chon...

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Bibliographic Details
Main Authors: Joshua Peter, Kaejaren C.N. Caldwell, Lucas McClain, Jason Tchieu, Ashley E. Ross, Yu Luo
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Neurobiology of Disease
Subjects:
PTPRS
Dopaminergic neurons
Synapses
Parkinson's disease
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996125002396
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