Distinct plasmablast developmental intermediates produce graded expression of IgM secretory transcripts
Summary: Differentiation into plasma cells (PCs) enables secretion of ∼10,000 immunoglobulin molecules per second. This extraordinary capacity requires the upregulation of PC transcriptional determinants that specify PC fate, increase immunoglobulin mRNA synthesis, coordinate alternative 3′ end proc...
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Main Authors: | Evelyn P. Sievert, Marissa C. Franke, Kayla B. Thomas, Yoseop Yoon, Yongsheng Shi, Roger Sciammas |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2025-02-01
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Series: | Cell Reports |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124725000543 |
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