Evaluation of Glucose 6-Phosphate Dehydrogenase, Pyruvate Kinase, and New Generation Inflammation Biomarkers in Prolonged Neonatal Jaundice
<i>Background and Objectives</i>: To evaluate the clinical findings of glucose 6-phosphate dehydrogenase (G6PD) and pyruvate kinase (PK) deficiency in prolonged jaundice and to determine whether the systemic immune inflammation index (SII), neutrophil-to-lymphocyte ratio (NLR), and plate...
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2024-09-01
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| author | Omer Okuyan Seyma Dumur Neval Elgormus Hafize Uzun |
| author_facet | Omer Okuyan Seyma Dumur Neval Elgormus Hafize Uzun |
| author_sort | Omer Okuyan |
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| description | <i>Background and Objectives</i>: To evaluate the clinical findings of glucose 6-phosphate dehydrogenase (G6PD) and pyruvate kinase (PK) deficiency in prolonged jaundice and to determine whether the systemic immune inflammation index (SII), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) can be used in the diagnosis of neonatal prolonged jaundice. <i>Materials and Methods</i>: Among full-term neonates with hyperbilirubinemia who were admitted to Medicine Hospital between January 2019 and January 2024 with the complaint of jaundice, 167 infants with a serum bilirubin level above 10 mg/dL, whose jaundice persisted after the 10th day, were included in this study. <i>Results</i>: G6PD activity was negatively correlated with NLR, SII, age, and hematocrit (Hct). There was a weak negative correlation between G6PD and NLR and a moderate negative correlation between G6PD activity and SII when adjusted for age and Hct. PK activity showed no significant correlation with G6PD, NLR, PLR, SII, age, and Hct. A linear relationship was observed between G6PD activity and SII and NLR. <i>Conclusions</i>: NLR and SII can be easily calculated in the evaluation of prolonged jaundice in G6PD deficiency has a considerable advantage. NLR and SII levels may contribute by preventing further tests for prolonged jaundice and regulating its treatment. It may be useful to form an opinion in emergencies and in early diagnostic period. |
| format | Article |
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| institution | OA Journals |
| issn | 1010-660X 1648-9144 |
| language | English |
| publishDate | 2024-09-01 |
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| spelling | doaj-art-ab77ab2f02574467a251f4581cf29d8a2025-08-20T01:55:40ZengMDPI AGMedicina1010-660X1648-91442024-09-01609149110.3390/medicina60091491Evaluation of Glucose 6-Phosphate Dehydrogenase, Pyruvate Kinase, and New Generation Inflammation Biomarkers in Prolonged Neonatal JaundiceOmer Okuyan0Seyma Dumur1Neval Elgormus2Hafize Uzun3Department of Pediatrics, Medicine Hospital, Faculty of Medicine, Istanbul Atlas University, 34408 Istanbul, TurkeyDepartment of Medical Biochemistry, Faculty of Medicine, Istanbul Atlas University, 34408 Istanbul, TurkeyDepartment of Microbiology, Faculty of Medicine, Istanbul Atlas University, 34408 Istanbul, TurkeyDepartment of Medical Biochemistry, Faculty of Medicine, Istanbul Atlas University, 34408 Istanbul, Turkey<i>Background and Objectives</i>: To evaluate the clinical findings of glucose 6-phosphate dehydrogenase (G6PD) and pyruvate kinase (PK) deficiency in prolonged jaundice and to determine whether the systemic immune inflammation index (SII), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) can be used in the diagnosis of neonatal prolonged jaundice. <i>Materials and Methods</i>: Among full-term neonates with hyperbilirubinemia who were admitted to Medicine Hospital between January 2019 and January 2024 with the complaint of jaundice, 167 infants with a serum bilirubin level above 10 mg/dL, whose jaundice persisted after the 10th day, were included in this study. <i>Results</i>: G6PD activity was negatively correlated with NLR, SII, age, and hematocrit (Hct). There was a weak negative correlation between G6PD and NLR and a moderate negative correlation between G6PD activity and SII when adjusted for age and Hct. PK activity showed no significant correlation with G6PD, NLR, PLR, SII, age, and Hct. A linear relationship was observed between G6PD activity and SII and NLR. <i>Conclusions</i>: NLR and SII can be easily calculated in the evaluation of prolonged jaundice in G6PD deficiency has a considerable advantage. NLR and SII levels may contribute by preventing further tests for prolonged jaundice and regulating its treatment. It may be useful to form an opinion in emergencies and in early diagnostic period.https://www.mdpi.com/1648-9144/60/9/1491prolonged jaundicebreast milkglucose 6-phosphate dehydrogenasepyruvate kinasesystemic immune inflammation indexneutrophil-to-lymphocyte ratio |
| spellingShingle | Omer Okuyan Seyma Dumur Neval Elgormus Hafize Uzun Evaluation of Glucose 6-Phosphate Dehydrogenase, Pyruvate Kinase, and New Generation Inflammation Biomarkers in Prolonged Neonatal Jaundice Medicina prolonged jaundice breast milk glucose 6-phosphate dehydrogenase pyruvate kinase systemic immune inflammation index neutrophil-to-lymphocyte ratio |
| title | Evaluation of Glucose 6-Phosphate Dehydrogenase, Pyruvate Kinase, and New Generation Inflammation Biomarkers in Prolonged Neonatal Jaundice |
| title_full | Evaluation of Glucose 6-Phosphate Dehydrogenase, Pyruvate Kinase, and New Generation Inflammation Biomarkers in Prolonged Neonatal Jaundice |
| title_fullStr | Evaluation of Glucose 6-Phosphate Dehydrogenase, Pyruvate Kinase, and New Generation Inflammation Biomarkers in Prolonged Neonatal Jaundice |
| title_full_unstemmed | Evaluation of Glucose 6-Phosphate Dehydrogenase, Pyruvate Kinase, and New Generation Inflammation Biomarkers in Prolonged Neonatal Jaundice |
| title_short | Evaluation of Glucose 6-Phosphate Dehydrogenase, Pyruvate Kinase, and New Generation Inflammation Biomarkers in Prolonged Neonatal Jaundice |
| title_sort | evaluation of glucose 6 phosphate dehydrogenase pyruvate kinase and new generation inflammation biomarkers in prolonged neonatal jaundice |
| topic | prolonged jaundice breast milk glucose 6-phosphate dehydrogenase pyruvate kinase systemic immune inflammation index neutrophil-to-lymphocyte ratio |
| url | https://www.mdpi.com/1648-9144/60/9/1491 |
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