Radiocobalt-Labeling of a Polypyridylamine Chelate Conjugated to GE11 for EGFR-Targeted Theranostics

Radiocobalt-Labeling of a Polypyridylamine Chelate Conjugated to GE11 for EGFR-Targeted Theranostics

The overexpression of the epidermal growth factor receptor (EGFR) in certain types of prostate cancers and glioblastoma makes it a promising target for targeted radioligand therapy. In this context, pairing an EGFR-targeting peptide with the emerging theranostic pair comprising the Auger electron em...

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Bibliographic Details
Main Authors: Lorraine Gaenaelle Gé, Mathias Bogetoft Danielsen, Aaraby Yoheswaran Nielsen, Mathias Lander Skavenborg, Niels Langkjær, Helge Thisgaard, Christine J. McKenzie
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Molecules
Subjects:
theranostics
Co isotopes (<sup>58m</sup>Co
<sup>57</sup>Co and <sup>55</sup>Co)
polypyridyl chelator
GE11
EGFR targeting
Online Access:https://www.mdpi.com/1420-3049/30/2/212
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