Silent magnetic resonance angiography diagnostic value of intracranial unruptured aneurysms
Abstract Silent magnetic resonance angiography (S-MRA) is primarily utilized to assess the blood flow in aneurysms and parent vessels of treated intracranial aneurysms. This study aimed to compare the diagnostic value of S-MRA and three-dimensional time of flight (3D-TOF) MRA for unruptured intracra...
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Nature Portfolio
2025-02-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-87646-9 |
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| author | Bin Lv Tingyang Zhang Ning Wang Lu Liu Mingyu Li Meng Li Mingguang Sun Xiao Zang Xinfeng Liu Rongju Zhang Xiangyu Cao Zhihua Du Jun Wang Jinhao Lyu Xueyang Wang Qi Duan Fangfang Guo Xin Lou Chenglin Tian |
| author_facet | Bin Lv Tingyang Zhang Ning Wang Lu Liu Mingyu Li Meng Li Mingguang Sun Xiao Zang Xinfeng Liu Rongju Zhang Xiangyu Cao Zhihua Du Jun Wang Jinhao Lyu Xueyang Wang Qi Duan Fangfang Guo Xin Lou Chenglin Tian |
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| description | Abstract Silent magnetic resonance angiography (S-MRA) is primarily utilized to assess the blood flow in aneurysms and parent vessels of treated intracranial aneurysms. This study aimed to compare the diagnostic value of S-MRA and three-dimensional time of flight (3D-TOF) MRA for unruptured intracranial aneurysms. We included patients diagnosed with unruptured intracranial aneurysms using digital subtraction angiography (DSA) who subsequently underwent S-MRA and 3D-TOF MRA. Two independent neuroimaging and neurointerventional doctors evaluated the DSA images and measured aneurysm dimensions. Using DSA results as the gold standard, we determined the sensitivity and specificity of S-MRA and 3D-TOF MRA, as well as their accuracy in measuring aneurysm size and identifying aneurysms with daughter sacs. We detected a total of 41 intracranial aneurysms (in 37 patients) on both S-MRA and 3D-TOF MRA, with both techniques achieving a sensitivity and specificity of 100%. For aneurysm height, the intraclass correlation coefficient (ICC) was 0.977 (P < 0.001) between S-MRA and DSA, and 0.908 (P < 0.001) between 3D-TOF MRA and DSA. For neck width, the ICC was 0.663 (P < 0.001) between S-MRA and DSA, and 0.563 (P < 0.001) between 3D-TOF MRA and DSA. In terms of daughter aneurysm detection, 3D-TOF MRA Sensitivity 40%; specificity 92%: positive predictive value 100%; S-MRA sensitivity 60%; specificity 89%; positive predictive value 42%. In conclusion, S-MRA and 3D-TOF MRA did not significantly differ in aneurysm detection ability. For the detection of aneurysm with dauthger sacs indicators, the sensitivity is also higher. |
| format | Article |
| id | doaj-art-ab74a92612494137a077e0ba4165791b |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-ab74a92612494137a077e0ba4165791b2025-02-09T12:36:21ZengNature PortfolioScientific Reports2045-23222025-02-011511810.1038/s41598-025-87646-9Silent magnetic resonance angiography diagnostic value of intracranial unruptured aneurysmsBin Lv0Tingyang Zhang1Ning Wang2Lu Liu3Mingyu Li4Meng Li5Mingguang Sun6Xiao Zang7Xinfeng Liu8Rongju Zhang9Xiangyu Cao10Zhihua Du11Jun Wang12Jinhao Lyu13Xueyang Wang14Qi Duan15Fangfang Guo16Xin Lou17Chenglin Tian18Department of Neurology, the First Medical Center, Chinese PLA General HospitalDepartment of Radiology, the First Medical Center, Chinese PLA General HospitalDepartment of Neurology, the First Medical Center, Chinese PLA General HospitalTaiyuan Wanbailin Medical Group Central HospitalDepartment of Internal Medicine, Gucheng County Hospital of Traditional Chinese MedicineDepartment of Radiology, the First Medical Center, Chinese PLA General HospitalDepartment of Neurology, Beijing Hospital of Integrated Traditional Chinese and Western MedicineDepartment of Radiology, the First Medical Center, Chinese PLA General HospitalDepartment of Neurology, the First Medical Center, Chinese PLA General HospitalDepartment of Neurology, the First Medical Center, Chinese PLA General HospitalDepartment of Neurology, the First Medical Center, Chinese PLA General HospitalDepartment of Neurology, the First Medical Center, Chinese PLA General HospitalDepartment of Neurology, the First Medical Center, Chinese PLA General HospitalDepartment of Radiology, the First Medical Center, Chinese PLA General HospitalDepartment of Radiology, the First Medical Center, Chinese PLA General HospitalDepartment of Radiology, the First Medical Center, Chinese PLA General HospitalDepartment of OutpatientDepartment of Radiology, the First Medical Center, Chinese PLA General HospitalDepartment of Neurology, the First Medical Center, Chinese PLA General HospitalAbstract Silent magnetic resonance angiography (S-MRA) is primarily utilized to assess the blood flow in aneurysms and parent vessels of treated intracranial aneurysms. This study aimed to compare the diagnostic value of S-MRA and three-dimensional time of flight (3D-TOF) MRA for unruptured intracranial aneurysms. We included patients diagnosed with unruptured intracranial aneurysms using digital subtraction angiography (DSA) who subsequently underwent S-MRA and 3D-TOF MRA. Two independent neuroimaging and neurointerventional doctors evaluated the DSA images and measured aneurysm dimensions. Using DSA results as the gold standard, we determined the sensitivity and specificity of S-MRA and 3D-TOF MRA, as well as their accuracy in measuring aneurysm size and identifying aneurysms with daughter sacs. We detected a total of 41 intracranial aneurysms (in 37 patients) on both S-MRA and 3D-TOF MRA, with both techniques achieving a sensitivity and specificity of 100%. For aneurysm height, the intraclass correlation coefficient (ICC) was 0.977 (P < 0.001) between S-MRA and DSA, and 0.908 (P < 0.001) between 3D-TOF MRA and DSA. For neck width, the ICC was 0.663 (P < 0.001) between S-MRA and DSA, and 0.563 (P < 0.001) between 3D-TOF MRA and DSA. In terms of daughter aneurysm detection, 3D-TOF MRA Sensitivity 40%; specificity 92%: positive predictive value 100%; S-MRA sensitivity 60%; specificity 89%; positive predictive value 42%. In conclusion, S-MRA and 3D-TOF MRA did not significantly differ in aneurysm detection ability. For the detection of aneurysm with dauthger sacs indicators, the sensitivity is also higher.https://doi.org/10.1038/s41598-025-87646-9S-MRA3D-TOF MRAIntracranial aneurysmsSubarachnoid hemorrhageThe ultrashort echo time. |
| spellingShingle | Bin Lv Tingyang Zhang Ning Wang Lu Liu Mingyu Li Meng Li Mingguang Sun Xiao Zang Xinfeng Liu Rongju Zhang Xiangyu Cao Zhihua Du Jun Wang Jinhao Lyu Xueyang Wang Qi Duan Fangfang Guo Xin Lou Chenglin Tian Silent magnetic resonance angiography diagnostic value of intracranial unruptured aneurysms Scientific Reports S-MRA 3D-TOF MRA Intracranial aneurysms Subarachnoid hemorrhage The ultrashort echo time. |
| title | Silent magnetic resonance angiography diagnostic value of intracranial unruptured aneurysms |
| title_full | Silent magnetic resonance angiography diagnostic value of intracranial unruptured aneurysms |
| title_fullStr | Silent magnetic resonance angiography diagnostic value of intracranial unruptured aneurysms |
| title_full_unstemmed | Silent magnetic resonance angiography diagnostic value of intracranial unruptured aneurysms |
| title_short | Silent magnetic resonance angiography diagnostic value of intracranial unruptured aneurysms |
| title_sort | silent magnetic resonance angiography diagnostic value of intracranial unruptured aneurysms |
| topic | S-MRA 3D-TOF MRA Intracranial aneurysms Subarachnoid hemorrhage The ultrashort echo time. |
| url | https://doi.org/10.1038/s41598-025-87646-9 |
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