Serpentine Supravenous Hyperpigmentation, a Phenomenon Following the Administration of Chemotherapeutic Agents: A Systematic Review
ABSTRACT Background Serpentine supravenous hyperpigmentation (SSH) is known as a phenomenon occurring during the infusion of chemotherapy agents in the underlying veins. Chemotherapy agents have potential to cause infusion reactions when used systematically. Linear hyperpigmentation and reticular hy...
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Wiley
2024-12-01
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| Series: | Health Science Reports |
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| Online Access: | https://doi.org/10.1002/hsr2.70294 |
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| author | Hanieh Radkhah Saba Maleki Razman Arabzadeh Bahri |
| author_facet | Hanieh Radkhah Saba Maleki Razman Arabzadeh Bahri |
| author_sort | Hanieh Radkhah |
| collection | DOAJ |
| description | ABSTRACT Background Serpentine supravenous hyperpigmentation (SSH) is known as a phenomenon occurring during the infusion of chemotherapy agents in the underlying veins. Chemotherapy agents have potential to cause infusion reactions when used systematically. Linear hyperpigmentation and reticular hyperpigmentation are the differential diagnosis for this phenomenon. The aim of the present study was to systematically review the serpentine supravenous dermatitis induced by chemotherapeutic agents. Methods A comprehensive search was conducted in Scopus, PubMed, Embase, and Web of Science bibliometric databases on February 7, 2023. The search keywords were categorized into two groups: SSH and chemotherapy. Any combination between keywords was used for the systematic search. We included any type of article that evaluated the SSH in cancer patients after the infusion of chemotherapeutic agents, including observational studies with at least one eligible patient based on our criteria, case series, and case reports. Studies that reported SSH in non‐cancer patients or caused by any medications other than chemotherapeutic agents were excluded. Results Twenty‐five studies were included based on our inclusion criteria consisting of 26 patients. A total of 13 different cancers were reported in the included studies. Lung cancer was the most reported cancer. Also, the mostly reported region of this dermatitis was forearm which was reported in 13 studies. Docetaxel has been used in a total of 11 articles in this study and has independently induced serpentine supravenous dermatitis in seven studies, which is the mostly reported chemotherapeutic agent resulting into serpentine supravenous dermatitis. Most of these skin lesions were self‐limiting and with a normal histopathological finding. Conclusion SSH is a dermatologic reaction, which mostly occur when there is peripheral venous access for the injection of chemotherapeutic agents. The skin lesion will improve spontaneously and have a benign course with no abnormal histopathological pathological finding. |
| format | Article |
| id | doaj-art-ab710fd546cb46a5a8a86f12c48f81c6 |
| institution | DOAJ |
| issn | 2398-8835 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Health Science Reports |
| spelling | doaj-art-ab710fd546cb46a5a8a86f12c48f81c62025-08-20T02:51:12ZengWileyHealth Science Reports2398-88352024-12-01712n/an/a10.1002/hsr2.70294Serpentine Supravenous Hyperpigmentation, a Phenomenon Following the Administration of Chemotherapeutic Agents: A Systematic ReviewHanieh Radkhah0Saba Maleki1Razman Arabzadeh Bahri2Internal Medicine Department, School of Medicine, Sina Hospital Tehran University of Medical Sciences Tehran IranSchool of Medicine Guilan University of Medical Sciences (GUMS) Rasht Guilan Province IranSchool of Medicine Tehran University of Medical Sciences Tehran IranABSTRACT Background Serpentine supravenous hyperpigmentation (SSH) is known as a phenomenon occurring during the infusion of chemotherapy agents in the underlying veins. Chemotherapy agents have potential to cause infusion reactions when used systematically. Linear hyperpigmentation and reticular hyperpigmentation are the differential diagnosis for this phenomenon. The aim of the present study was to systematically review the serpentine supravenous dermatitis induced by chemotherapeutic agents. Methods A comprehensive search was conducted in Scopus, PubMed, Embase, and Web of Science bibliometric databases on February 7, 2023. The search keywords were categorized into two groups: SSH and chemotherapy. Any combination between keywords was used for the systematic search. We included any type of article that evaluated the SSH in cancer patients after the infusion of chemotherapeutic agents, including observational studies with at least one eligible patient based on our criteria, case series, and case reports. Studies that reported SSH in non‐cancer patients or caused by any medications other than chemotherapeutic agents were excluded. Results Twenty‐five studies were included based on our inclusion criteria consisting of 26 patients. A total of 13 different cancers were reported in the included studies. Lung cancer was the most reported cancer. Also, the mostly reported region of this dermatitis was forearm which was reported in 13 studies. Docetaxel has been used in a total of 11 articles in this study and has independently induced serpentine supravenous dermatitis in seven studies, which is the mostly reported chemotherapeutic agent resulting into serpentine supravenous dermatitis. Most of these skin lesions were self‐limiting and with a normal histopathological finding. Conclusion SSH is a dermatologic reaction, which mostly occur when there is peripheral venous access for the injection of chemotherapeutic agents. The skin lesion will improve spontaneously and have a benign course with no abnormal histopathological pathological finding.https://doi.org/10.1002/hsr2.70294chemotherapydocetaxelserpentine supravenous hyperpigmentation |
| spellingShingle | Hanieh Radkhah Saba Maleki Razman Arabzadeh Bahri Serpentine Supravenous Hyperpigmentation, a Phenomenon Following the Administration of Chemotherapeutic Agents: A Systematic Review Health Science Reports chemotherapy docetaxel serpentine supravenous hyperpigmentation |
| title | Serpentine Supravenous Hyperpigmentation, a Phenomenon Following the Administration of Chemotherapeutic Agents: A Systematic Review |
| title_full | Serpentine Supravenous Hyperpigmentation, a Phenomenon Following the Administration of Chemotherapeutic Agents: A Systematic Review |
| title_fullStr | Serpentine Supravenous Hyperpigmentation, a Phenomenon Following the Administration of Chemotherapeutic Agents: A Systematic Review |
| title_full_unstemmed | Serpentine Supravenous Hyperpigmentation, a Phenomenon Following the Administration of Chemotherapeutic Agents: A Systematic Review |
| title_short | Serpentine Supravenous Hyperpigmentation, a Phenomenon Following the Administration of Chemotherapeutic Agents: A Systematic Review |
| title_sort | serpentine supravenous hyperpigmentation a phenomenon following the administration of chemotherapeutic agents a systematic review |
| topic | chemotherapy docetaxel serpentine supravenous hyperpigmentation |
| url | https://doi.org/10.1002/hsr2.70294 |
| work_keys_str_mv | AT haniehradkhah serpentinesupravenoushyperpigmentationaphenomenonfollowingtheadministrationofchemotherapeuticagentsasystematicreview AT sabamaleki serpentinesupravenoushyperpigmentationaphenomenonfollowingtheadministrationofchemotherapeuticagentsasystematicreview AT razmanarabzadehbahri serpentinesupravenoushyperpigmentationaphenomenonfollowingtheadministrationofchemotherapeuticagentsasystematicreview |