Prevalence and Antimicrobial-Resistant Features of Shigella Species in East Africa from 2015–2022: A Systematic Review and Meta-Analysis
Background. Shigellosis is the most common cause of epidemic dysentery found worldwide, particularly in developing countries, where it causes infant diarrhea and mortality. The prevalence of Shigella species resistant to commonly used antimicrobial drugs has steadily increased. The purpose of this r...
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| Format: | Article |
| Language: | English |
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Wiley
2023-01-01
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| Series: | Interdisciplinary Perspectives on Infectious Diseases |
| Online Access: | http://dx.doi.org/10.1155/2023/8277976 |
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| author | Basha Ayele Getenet Beyene Mekdelawit Alemayehu Aman Dekebo Zeleke Mekonnen Gashaw Nigussie |
| author_facet | Basha Ayele Getenet Beyene Mekdelawit Alemayehu Aman Dekebo Zeleke Mekonnen Gashaw Nigussie |
| author_sort | Basha Ayele |
| collection | DOAJ |
| description | Background. Shigellosis is the most common cause of epidemic dysentery found worldwide, particularly in developing countries, where it causes infant diarrhea and mortality. The prevalence of Shigella species resistant to commonly used antimicrobial drugs has steadily increased. The purpose of this review is to describe the prevalence and antimicrobial resistance (AMR) characteristics of Shigella species in East Africa between 2015 and 2022. Methods. Studies were identified using a computerized search of Medline/PubMed, Google Scholar, and Web of Science databases, with a detailed search strategy and cross-checking of reference lists for studies published between 2015 and 2022. Articles presenting data on prevalence and AMR, accessibility of the full-length article, and publication dates between 2015 and 2022 were the eligibility criteria for inclusion in the review. Original research reports written in English were considered. The heterogeneities of the studies were examined, and a meta-analysis was performed to estimate the pooled prevalence and AMR using a random effects model. Results. The pooled prevalence of Shigella species in East Africa was 6.2% (95% CI −0.20–12.60), according to an analysis of 22 studies. Shigella species prevalence was 4.0% in Ethiopia, 14.6% in Kenya, 0.7% in Sudan, 5.2% in South Sudan, and 20.6% in Somalia. The association of Shigella infection significantly varied among the countries (p=0.01). Among the antibiotics tested, most Shigella isolates were susceptible to ciprofloxacin, norfloxacin, nalidixic acid, and ceftriaxone. Despite the fact that the reports varied in study sites and time, Shigella species were resistant to tetracycline, ampicillin, amoxicillin, chloramphenicol, and co-trimoxazole. Conclusion. The pooled estimate indicates high burden of Shigella infection in East Africa, as well as a high proportion of drug resistance pattern to tetracycline, ampicillin, chloramphenicol, and amoxicillin. Therefore, initiating and scale-up of performing drug susceptibility test for each shigellosis case need to be considered and strengthened. |
| format | Article |
| id | doaj-art-ab6fc6d52c8b44da99804845b1e1fc53 |
| institution | Kabale University |
| issn | 1687-7098 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Interdisciplinary Perspectives on Infectious Diseases |
| spelling | doaj-art-ab6fc6d52c8b44da99804845b1e1fc532025-08-20T03:24:30ZengWileyInterdisciplinary Perspectives on Infectious Diseases1687-70982023-01-01202310.1155/2023/8277976Prevalence and Antimicrobial-Resistant Features of Shigella Species in East Africa from 2015–2022: A Systematic Review and Meta-AnalysisBasha Ayele0Getenet Beyene1Mekdelawit Alemayehu2Aman Dekebo3Zeleke Mekonnen4Gashaw Nigussie5Department of Medical Laboratory ScienceSchool of Medical Laboratory SciencesArmauer Hansen Research InstituteDepartment of Applied ChemistrySchool of Medical Laboratory SciencesArmauer Hansen Research InstituteBackground. Shigellosis is the most common cause of epidemic dysentery found worldwide, particularly in developing countries, where it causes infant diarrhea and mortality. The prevalence of Shigella species resistant to commonly used antimicrobial drugs has steadily increased. The purpose of this review is to describe the prevalence and antimicrobial resistance (AMR) characteristics of Shigella species in East Africa between 2015 and 2022. Methods. Studies were identified using a computerized search of Medline/PubMed, Google Scholar, and Web of Science databases, with a detailed search strategy and cross-checking of reference lists for studies published between 2015 and 2022. Articles presenting data on prevalence and AMR, accessibility of the full-length article, and publication dates between 2015 and 2022 were the eligibility criteria for inclusion in the review. Original research reports written in English were considered. The heterogeneities of the studies were examined, and a meta-analysis was performed to estimate the pooled prevalence and AMR using a random effects model. Results. The pooled prevalence of Shigella species in East Africa was 6.2% (95% CI −0.20–12.60), according to an analysis of 22 studies. Shigella species prevalence was 4.0% in Ethiopia, 14.6% in Kenya, 0.7% in Sudan, 5.2% in South Sudan, and 20.6% in Somalia. The association of Shigella infection significantly varied among the countries (p=0.01). Among the antibiotics tested, most Shigella isolates were susceptible to ciprofloxacin, norfloxacin, nalidixic acid, and ceftriaxone. Despite the fact that the reports varied in study sites and time, Shigella species were resistant to tetracycline, ampicillin, amoxicillin, chloramphenicol, and co-trimoxazole. Conclusion. The pooled estimate indicates high burden of Shigella infection in East Africa, as well as a high proportion of drug resistance pattern to tetracycline, ampicillin, chloramphenicol, and amoxicillin. Therefore, initiating and scale-up of performing drug susceptibility test for each shigellosis case need to be considered and strengthened.http://dx.doi.org/10.1155/2023/8277976 |
| spellingShingle | Basha Ayele Getenet Beyene Mekdelawit Alemayehu Aman Dekebo Zeleke Mekonnen Gashaw Nigussie Prevalence and Antimicrobial-Resistant Features of Shigella Species in East Africa from 2015–2022: A Systematic Review and Meta-Analysis Interdisciplinary Perspectives on Infectious Diseases |
| title | Prevalence and Antimicrobial-Resistant Features of Shigella Species in East Africa from 2015–2022: A Systematic Review and Meta-Analysis |
| title_full | Prevalence and Antimicrobial-Resistant Features of Shigella Species in East Africa from 2015–2022: A Systematic Review and Meta-Analysis |
| title_fullStr | Prevalence and Antimicrobial-Resistant Features of Shigella Species in East Africa from 2015–2022: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Prevalence and Antimicrobial-Resistant Features of Shigella Species in East Africa from 2015–2022: A Systematic Review and Meta-Analysis |
| title_short | Prevalence and Antimicrobial-Resistant Features of Shigella Species in East Africa from 2015–2022: A Systematic Review and Meta-Analysis |
| title_sort | prevalence and antimicrobial resistant features of shigella species in east africa from 2015 2022 a systematic review and meta analysis |
| url | http://dx.doi.org/10.1155/2023/8277976 |
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