Hypoxic glioma-derived exosomal miR-25-3p promotes macrophage M2 polarization by activating the PI3K-AKT-mTOR signaling pathway

Hypoxic glioma-derived exosomal miR-25-3p promotes macrophage M2 polarization by activating the PI3K-AKT-mTOR signaling pathway

Abstract Background Exosomes (EXO) play crucial roles in intercellular communication and glioma microenvironment modulation. Tumor-associated macrophages are more likely to become M2-like type macrophages in the immunosuppressive microenvironment. Here, we aimed to investigate the effects and molecu...

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Bibliographic Details
Main Authors: Zhiwei Xue, Junzhi Liu, Wenchen Xing, Feiyu Mu, Yanzhao Wu, Jiangli Zhao, Xuchen Liu, Donghai Wang, Jian Wang, Xingang Li, Jiwei Wang, Bin Huang
Format: Article
Language:English
Published: BMC 2024-10-01
Series:Journal of Nanobiotechnology
Subjects:
Glioma
Exosomes
miRNAs
PHLPP2
AKT-mTOR
Online Access:https://doi.org/10.1186/s12951-024-02888-5
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