Associations of Genetically Predicted NPR3 and NPR2 Perturbation and Preeclampsia Risk: A Two-Sample Mendelian Randomization Analysis
Conclusion: This study employed the MR paradigm to provide genetic evidence supporting the protective effects of CNP (through reduced NPR3 function) on the risk of preeclampsia. However, it is important to gather additional evidence from other sources before moving forward with clinical development...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2025-01-01
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| Series: | International Journal of Hypertension |
| Online Access: | http://dx.doi.org/10.1155/ijhy/9972031 |
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| _version_ | 1849328445349167104 |
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| author | Roxane de La Harpe Tormod Rogne Michael Nyberg Héléne T. Cronjé Stephen Burgess Ville Karhunen Dipender Gill |
| author_facet | Roxane de La Harpe Tormod Rogne Michael Nyberg Héléne T. Cronjé Stephen Burgess Ville Karhunen Dipender Gill |
| author_sort | Roxane de La Harpe |
| collection | DOAJ |
| description | Conclusion: This study employed the MR paradigm to provide genetic evidence supporting the protective effects of CNP (through reduced NPR3 function) on the risk of preeclampsia. However, it is important to gather additional evidence from other sources before moving forward with clinical development efforts to explore CNP as a potential treatment for preeclampsia. |
| format | Article |
| id | doaj-art-ab6951be054d4c8faf7f0537a653bc47 |
| institution | Kabale University |
| issn | 2090-0392 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Hypertension |
| spelling | doaj-art-ab6951be054d4c8faf7f0537a653bc472025-08-20T03:47:36ZengWileyInternational Journal of Hypertension2090-03922025-01-01202510.1155/ijhy/9972031Associations of Genetically Predicted NPR3 and NPR2 Perturbation and Preeclampsia Risk: A Two-Sample Mendelian Randomization AnalysisRoxane de La Harpe0Tormod Rogne1Michael Nyberg2Héléne T. Cronjé3Stephen Burgess4Ville Karhunen5Dipender Gill6Department of MedicineDepartment of Community Medicine and Global HealthResearch and Early DevelopmentMRC Biostatistics UnitMRC Biostatistics UnitMRC Biostatistics UnitDepartment of Epidemiology and BiostatisticsConclusion: This study employed the MR paradigm to provide genetic evidence supporting the protective effects of CNP (through reduced NPR3 function) on the risk of preeclampsia. However, it is important to gather additional evidence from other sources before moving forward with clinical development efforts to explore CNP as a potential treatment for preeclampsia.http://dx.doi.org/10.1155/ijhy/9972031 |
| spellingShingle | Roxane de La Harpe Tormod Rogne Michael Nyberg Héléne T. Cronjé Stephen Burgess Ville Karhunen Dipender Gill Associations of Genetically Predicted NPR3 and NPR2 Perturbation and Preeclampsia Risk: A Two-Sample Mendelian Randomization Analysis International Journal of Hypertension |
| title | Associations of Genetically Predicted NPR3 and NPR2 Perturbation and Preeclampsia Risk: A Two-Sample Mendelian Randomization Analysis |
| title_full | Associations of Genetically Predicted NPR3 and NPR2 Perturbation and Preeclampsia Risk: A Two-Sample Mendelian Randomization Analysis |
| title_fullStr | Associations of Genetically Predicted NPR3 and NPR2 Perturbation and Preeclampsia Risk: A Two-Sample Mendelian Randomization Analysis |
| title_full_unstemmed | Associations of Genetically Predicted NPR3 and NPR2 Perturbation and Preeclampsia Risk: A Two-Sample Mendelian Randomization Analysis |
| title_short | Associations of Genetically Predicted NPR3 and NPR2 Perturbation and Preeclampsia Risk: A Two-Sample Mendelian Randomization Analysis |
| title_sort | associations of genetically predicted npr3 and npr2 perturbation and preeclampsia risk a two sample mendelian randomization analysis |
| url | http://dx.doi.org/10.1155/ijhy/9972031 |
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