Acute cell rejection of a kidney transplant in a patient of african origin: clinical observation
The origin of the recipient is one of the recipient-related factors that statistically significantly affects the outcomes of kidney transplantation, but this factor is not so relevant in our country. The article presents the first experience of kidney transplantation in a patient of African descent...
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| Format: | Article |
| Language: | Russian |
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Private institution educational organization of higher education "Medical University "ReaViz"
2023-05-01
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| Series: | Вестник медицинского института «Реавиз»: Реабилитация, врач и здоровье |
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| Online Access: | https://vestnik.reaviz.ru/jour/article/view/660 |
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| author | M. Sh. Khubutiya V. O. Aleksandrova A. G. Balkarov V. E. Vinogradov N. V. Zagorodnikova R. V. Storozhev N. V. Shmarina N. V. Borovkova I. V. Dmitriev |
| author_facet | M. Sh. Khubutiya V. O. Aleksandrova A. G. Balkarov V. E. Vinogradov N. V. Zagorodnikova R. V. Storozhev N. V. Shmarina N. V. Borovkova I. V. Dmitriev |
| author_sort | M. Sh. Khubutiya |
| collection | DOAJ |
| description | The origin of the recipient is one of the recipient-related factors that statistically significantly affects the outcomes of kidney transplantation, but this factor is not so relevant in our country. The article presents the first experience of kidney transplantation in a patient of African descent at the N.I. N.V. Sklifosovsky.Material and methods. Allogeneic renal graft transplantation from a post-mortem donor was performed in a 60-year-old African male patient with stage 5 chronic kidney disease as a result of hypertensive nephroangiosclerosis.Results. The early postoperative period was complicated by the development of acute cellular graft rejection grade 1a-b according to Banff. Anti-crisis therapy was performed with some positive effect, however, in the late postoperative period, a loss of renal graft function was noted, and the patient was returned to renal replacement therapy with program hemodialysis.Conclusion. Patients of African ancestry are at increased risk of adverse outcomes due to immunological causes and require more careful immunological selection of a donor organ, an enhanced immunosuppressive regimen, and close monitoring after transplantation. |
| format | Article |
| id | doaj-art-ab605af285904c8fa14b04f103eb421d |
| institution | Kabale University |
| issn | 2226-762X 2782-1579 |
| language | Russian |
| publishDate | 2023-05-01 |
| publisher | Private institution educational organization of higher education "Medical University "ReaViz" |
| record_format | Article |
| series | Вестник медицинского института «Реавиз»: Реабилитация, врач и здоровье |
| spelling | doaj-art-ab605af285904c8fa14b04f103eb421d2025-08-20T03:37:22ZrusPrivate institution educational organization of higher education "Medical University "ReaViz"Вестник медицинского института «Реавиз»: Реабилитация, врач и здоровье2226-762X2782-15792023-05-0113211211610.20340/vmi-rvz.2023.2.TX.1417Acute cell rejection of a kidney transplant in a patient of african origin: clinical observationM. Sh. Khubutiya0V. O. Aleksandrova1A. G. Balkarov2V. E. Vinogradov3N. V. Zagorodnikova4R. V. Storozhev5N. V. Shmarina6N. V. Borovkova7I. V. Dmitriev8N.V. Sklifosovsky Research Institute of Emergency Medicine; Moscow State Medical and Dental University named after A.I. Evdokimov; Research Institute of Healthcare Organization and Medical Management Department of Health of the City of MoscowN.V. Sklifosovsky Research Institute of Emergency MedicineN.V. Sklifosovsky Research Institute of Emergency Medicine; Pirogov Russian National Research Medical University; Research Institute of Healthcare Organization and Medical Management Department of Health of the City of MoscowResearch Institute of Healthcare Organization and Medical Management Department of Health of the City of Moscow; City Clinical Hospital No. 52 of the Moscow City Health DepartmentN.V. Sklifosovsky Research Institute of Emergency MedicineN.V. Sklifosovsky Research Institute of Emergency MedicineN.V. Sklifosovsky Research Institute of Emergency Medicine; Pirogov Russian National Research Medical UniversityN.V. Sklifosovsky Research Institute of Emergency Medicine; Pirogov Russian National Research Medical UniversityN.V. Sklifosovsky Research Institute of Emergency Medicine; Pirogov Russian National Research Medical UniversityThe origin of the recipient is one of the recipient-related factors that statistically significantly affects the outcomes of kidney transplantation, but this factor is not so relevant in our country. The article presents the first experience of kidney transplantation in a patient of African descent at the N.I. N.V. Sklifosovsky.Material and methods. Allogeneic renal graft transplantation from a post-mortem donor was performed in a 60-year-old African male patient with stage 5 chronic kidney disease as a result of hypertensive nephroangiosclerosis.Results. The early postoperative period was complicated by the development of acute cellular graft rejection grade 1a-b according to Banff. Anti-crisis therapy was performed with some positive effect, however, in the late postoperative period, a loss of renal graft function was noted, and the patient was returned to renal replacement therapy with program hemodialysis.Conclusion. Patients of African ancestry are at increased risk of adverse outcomes due to immunological causes and require more careful immunological selection of a donor organ, an enhanced immunosuppressive regimen, and close monitoring after transplantation.https://vestnik.reaviz.ru/jour/article/view/660kidney transplantationpatient of african descentacute rejection crisisloss of a kidney transplant |
| spellingShingle | M. Sh. Khubutiya V. O. Aleksandrova A. G. Balkarov V. E. Vinogradov N. V. Zagorodnikova R. V. Storozhev N. V. Shmarina N. V. Borovkova I. V. Dmitriev Acute cell rejection of a kidney transplant in a patient of african origin: clinical observation Вестник медицинского института «Реавиз»: Реабилитация, врач и здоровье kidney transplantation patient of african descent acute rejection crisis loss of a kidney transplant |
| title | Acute cell rejection of a kidney transplant in a patient of african origin: clinical observation |
| title_full | Acute cell rejection of a kidney transplant in a patient of african origin: clinical observation |
| title_fullStr | Acute cell rejection of a kidney transplant in a patient of african origin: clinical observation |
| title_full_unstemmed | Acute cell rejection of a kidney transplant in a patient of african origin: clinical observation |
| title_short | Acute cell rejection of a kidney transplant in a patient of african origin: clinical observation |
| title_sort | acute cell rejection of a kidney transplant in a patient of african origin clinical observation |
| topic | kidney transplantation patient of african descent acute rejection crisis loss of a kidney transplant |
| url | https://vestnik.reaviz.ru/jour/article/view/660 |
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