Protection of Salvia miltiorrhizae to the Spleen and Thymus of Rats with Severe Acute Pancreatitis or Obstructive Jaundice
Objective. To investigate the therapeutic effects and mechanism of Salvia miltiorrhizae in the treatment of SAP and OJ. Methods. A total of 288 rats were used for SAP- and OJ-associated experiments. The rats were randomly divided into sham-operated group, model control group and treated group. The m...
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| Format: | Article |
| Language: | English |
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Wiley
2009-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2009/186136 |
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| _version_ | 1850171694665170944 |
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| author | Zhang Xiping Li Chuyang Zhang Jie Ruan Yuefang Ma Meili |
| author_facet | Zhang Xiping Li Chuyang Zhang Jie Ruan Yuefang Ma Meili |
| author_sort | Zhang Xiping |
| collection | DOAJ |
| description | Objective. To investigate the therapeutic effects and mechanism of Salvia miltiorrhizae in the treatment of SAP and OJ. Methods. A total of 288 rats were used for SAP- and OJ-associated experiments. The rats were randomly divided into sham-operated group, model control group and treated group. The mortality rates of rats, contents of endotoxin and PLA2 in blood, patholodgical changes of different indexes in spleen and thymus were observed. Results. The contents of endotoxin and PLA2 in treated group were significantly lower than those in model control group.The pathological severity scores of spleen and thymus of SAP rats as well as that of spleen of OJ rats in treated groups were significantly lower than those in model control groups (P<.05). The staining intensity as well as the product of the staining intensity and positive rate of Bax protein of spleen in model control group were significantly higher than those in treated groups (P<.01) , and the apoptosis index of spleen in treated group was significantly lower than that in model control group (P<.01).
Conclusion. Salvia miltiorrhizae exerts protective effects on the spleen and thymus of SAP rats and spleen of OJ rats. |
| format | Article |
| id | doaj-art-ab5c8fc6639442fe860fede0918fcb0c |
| institution | OA Journals |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-ab5c8fc6639442fe860fede0918fcb0c2025-08-20T02:20:13ZengWileyMediators of Inflammation0962-93511466-18612009-01-01200910.1155/2009/186136186136Protection of Salvia miltiorrhizae to the Spleen and Thymus of Rats with Severe Acute Pancreatitis or Obstructive JaundiceZhang Xiping0Li Chuyang1Zhang Jie2Ruan Yuefang3Ma Meili4Department of General Surgery, Hangzhou First People’s Hospital, Hangzhou 310006, Zhejiang Province, ChinaLibrary, Hangzhou First People’s Hospital, Hangzhou 310006, Zhejiang Province, ChinaThe First College of Clinical Medicine, Zhejiang University of Traditional Chinese Medicine, Hangzhou 3100053, ChinaThe First College of Clinical Medicine, Zhejiang University of Traditional Chinese Medicine, Hangzhou 3100053, ChinaDepartment of Nephropathy, 117 Hospital of People’s Liberation Army, Hangzhou 310013, Zhejiang Province, ChinaObjective. To investigate the therapeutic effects and mechanism of Salvia miltiorrhizae in the treatment of SAP and OJ. Methods. A total of 288 rats were used for SAP- and OJ-associated experiments. The rats were randomly divided into sham-operated group, model control group and treated group. The mortality rates of rats, contents of endotoxin and PLA2 in blood, patholodgical changes of different indexes in spleen and thymus were observed. Results. The contents of endotoxin and PLA2 in treated group were significantly lower than those in model control group.The pathological severity scores of spleen and thymus of SAP rats as well as that of spleen of OJ rats in treated groups were significantly lower than those in model control groups (P<.05). The staining intensity as well as the product of the staining intensity and positive rate of Bax protein of spleen in model control group were significantly higher than those in treated groups (P<.01) , and the apoptosis index of spleen in treated group was significantly lower than that in model control group (P<.01). Conclusion. Salvia miltiorrhizae exerts protective effects on the spleen and thymus of SAP rats and spleen of OJ rats.http://dx.doi.org/10.1155/2009/186136 |
| spellingShingle | Zhang Xiping Li Chuyang Zhang Jie Ruan Yuefang Ma Meili Protection of Salvia miltiorrhizae to the Spleen and Thymus of Rats with Severe Acute Pancreatitis or Obstructive Jaundice Mediators of Inflammation |
| title | Protection of Salvia miltiorrhizae to the Spleen and Thymus of Rats with Severe Acute Pancreatitis or Obstructive Jaundice |
| title_full | Protection of Salvia miltiorrhizae to the Spleen and Thymus of Rats with Severe Acute Pancreatitis or Obstructive Jaundice |
| title_fullStr | Protection of Salvia miltiorrhizae to the Spleen and Thymus of Rats with Severe Acute Pancreatitis or Obstructive Jaundice |
| title_full_unstemmed | Protection of Salvia miltiorrhizae to the Spleen and Thymus of Rats with Severe Acute Pancreatitis or Obstructive Jaundice |
| title_short | Protection of Salvia miltiorrhizae to the Spleen and Thymus of Rats with Severe Acute Pancreatitis or Obstructive Jaundice |
| title_sort | protection of salvia miltiorrhizae to the spleen and thymus of rats with severe acute pancreatitis or obstructive jaundice |
| url | http://dx.doi.org/10.1155/2009/186136 |
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