Abnormalities of lipid metabolism in the progression and treatment of depression
Depression represents a global health challenge with complex etiology and significant societal impact. Recent advancements reveal a critical role of lipid metabolism dysregulation in the pathogenesis and severity of depressive disorders. This review elucidates the impact of lipid imbalance on depres...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-05-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2025.1589663/full |
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| author | Xinchi Luan Xuezhe Wang Ying Shi Ying Shi Xinyi Zhang Yilin Wang Miao Zhou Zhaoyi Wu Zijiao Liu Xiaoxuan Li Lihua Zhang Tianyi Shao Ruolan Chen Xianming Chu Hongyun Wei Hongyun Wei |
| author_facet | Xinchi Luan Xuezhe Wang Ying Shi Ying Shi Xinyi Zhang Yilin Wang Miao Zhou Zhaoyi Wu Zijiao Liu Xiaoxuan Li Lihua Zhang Tianyi Shao Ruolan Chen Xianming Chu Hongyun Wei Hongyun Wei |
| author_sort | Xinchi Luan |
| collection | DOAJ |
| description | Depression represents a global health challenge with complex etiology and significant societal impact. Recent advancements reveal a critical role of lipid metabolism dysregulation in the pathogenesis and severity of depressive disorders. This review elucidates the impact of lipid imbalance on depression highlighting how dyslipidemia not only makes individuals prone to depression but also exacerbates the progression of depression (including the occurrence of some comorbidities of depression). On this basis, we have summarized that abnormal lipid metabolism may serve as a diagnostic and therapeutic target for depression. We discuss the perturbation of lipid homeostasis in depression, marked by altered triglycerides and high-density lipoprotein levels, and the potential of these lipids as biomarkers for diagnostic precision and therapeutic efficacy. Special emphasis is placed on the molecular mechanisms where lipids influence neuronal function and stress responses, thereby affecting mood and cognitive outcomes. Furthermore, we explore the comorbidity of depression with other systemic illnesses, suggesting a shared lipid-mediated metabolic pathway. Given the integral role of lipids in neural architecture and signaling, targeting lipid metabolism could offer novel therapeutic avenues, enhancing neuroplasticity and potentially mitigating depressive symptoms. Our synthesis aims to pave the way for future investigations into lipid-centric strategies to combat depression, advocating for a metabolic reorientation in mental health therapeutics. |
| format | Article |
| id | doaj-art-ab5ac92e7a7f4568bf320910f819a2f3 |
| institution | DOAJ |
| issn | 1664-0640 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj-art-ab5ac92e7a7f4568bf320910f819a2f32025-08-20T03:21:50ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402025-05-011610.3389/fpsyt.2025.15896631589663Abnormalities of lipid metabolism in the progression and treatment of depressionXinchi Luan0Xuezhe Wang1Ying Shi2Ying Shi3Xinyi Zhang4Yilin Wang5Miao Zhou6Zhaoyi Wu7Zijiao Liu8Xiaoxuan Li9Lihua Zhang10Tianyi Shao11Ruolan Chen12Xianming Chu13Hongyun Wei14Hongyun Wei15Department of Oncology, Key Laboratory of Cancer Molecular and Translational Research, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, ChinaDepartment of Cardiology, The Affiliated Hospital of Qingdao University, Qingdao, ChinaDepartment of Gastroenterology, the affiliated hospital of Qingdao university, Qingdao, Shandong, ChinaCenter of Tumor Immunology and Cytotherapy, Medical Research Center, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, ChinaSchool of Basic Medicine, Qingdao University, Qingdao, Shandong, ChinaSchool of Basic Medicine, Qingdao University, Qingdao, Shandong, ChinaSchool of Basic Medicine, Qingdao University, Qingdao, Shandong, ChinaDepartment of Gastroenterology, the affiliated hospital of Qingdao university, Qingdao, Shandong, ChinaShandong First Medical University & Shandong Academy of Medical Sciences, Jinan, ChinaDepartment of Oncology, Key Laboratory of Cancer Molecular and Translational Research, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, ChinaDepartment of Oncology, Key Laboratory of Cancer Molecular and Translational Research, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, ChinaSchool of Basic Medicine, Qingdao University, Qingdao, Shandong, ChinaDepartment of Cardiology, The Affiliated Hospital of Qingdao University, Qingdao, ChinaDepartment of Cardiology, The Affiliated Hospital of Qingdao University, Qingdao, ChinaDepartment of Gastroenterology, the affiliated hospital of Qingdao university, Qingdao, Shandong, ChinaCenter of Tumor Immunology and Cytotherapy, Medical Research Center, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, ChinaDepression represents a global health challenge with complex etiology and significant societal impact. Recent advancements reveal a critical role of lipid metabolism dysregulation in the pathogenesis and severity of depressive disorders. This review elucidates the impact of lipid imbalance on depression highlighting how dyslipidemia not only makes individuals prone to depression but also exacerbates the progression of depression (including the occurrence of some comorbidities of depression). On this basis, we have summarized that abnormal lipid metabolism may serve as a diagnostic and therapeutic target for depression. We discuss the perturbation of lipid homeostasis in depression, marked by altered triglycerides and high-density lipoprotein levels, and the potential of these lipids as biomarkers for diagnostic precision and therapeutic efficacy. Special emphasis is placed on the molecular mechanisms where lipids influence neuronal function and stress responses, thereby affecting mood and cognitive outcomes. Furthermore, we explore the comorbidity of depression with other systemic illnesses, suggesting a shared lipid-mediated metabolic pathway. Given the integral role of lipids in neural architecture and signaling, targeting lipid metabolism could offer novel therapeutic avenues, enhancing neuroplasticity and potentially mitigating depressive symptoms. Our synthesis aims to pave the way for future investigations into lipid-centric strategies to combat depression, advocating for a metabolic reorientation in mental health therapeutics.https://www.frontiersin.org/articles/10.3389/fpsyt.2025.1589663/fulldepressionlipid metabolismdyslipidemiabiomarkerstherapeutic targetscomorbidity |
| spellingShingle | Xinchi Luan Xuezhe Wang Ying Shi Ying Shi Xinyi Zhang Yilin Wang Miao Zhou Zhaoyi Wu Zijiao Liu Xiaoxuan Li Lihua Zhang Tianyi Shao Ruolan Chen Xianming Chu Hongyun Wei Hongyun Wei Abnormalities of lipid metabolism in the progression and treatment of depression Frontiers in Psychiatry depression lipid metabolism dyslipidemia biomarkers therapeutic targets comorbidity |
| title | Abnormalities of lipid metabolism in the progression and treatment of depression |
| title_full | Abnormalities of lipid metabolism in the progression and treatment of depression |
| title_fullStr | Abnormalities of lipid metabolism in the progression and treatment of depression |
| title_full_unstemmed | Abnormalities of lipid metabolism in the progression and treatment of depression |
| title_short | Abnormalities of lipid metabolism in the progression and treatment of depression |
| title_sort | abnormalities of lipid metabolism in the progression and treatment of depression |
| topic | depression lipid metabolism dyslipidemia biomarkers therapeutic targets comorbidity |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2025.1589663/full |
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