Sudden death in a child with epilepsy: potential cerebellar mechanisms?
Epilepsy is the most common neurological disorder in humans. People with epilepsy are more likely to die prematurely than those without epilepsy, with the most common epilepsy-related category of death being sudden unexpected death in epilepsy (SUDEP). The central mechanisms underlying the fatal pro...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Thieme Revinter Publicações
2011-08-01
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| Series: | Arquivos de Neuro-Psiquiatria |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2011000500024&lng=en&tlng=en |
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| _version_ | 1850244855629873152 |
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| author | Fulvio A. Scorza Vera C. Terra Ricardo M. Arida Américo C. Sakamoto Ronald M. Harper |
| author_facet | Fulvio A. Scorza Vera C. Terra Ricardo M. Arida Américo C. Sakamoto Ronald M. Harper |
| author_sort | Fulvio A. Scorza |
| collection | DOAJ |
| description | Epilepsy is the most common neurological disorder in humans. People with epilepsy are more likely to die prematurely than those without epilepsy, with the most common epilepsy-related category of death being sudden unexpected death in epilepsy (SUDEP). The central mechanisms underlying the fatal process remain unclear, but cardiac and respiratory mechanisms appear to be involved. Recently, cerebellar, thalamic, basal ganglia and limbic brain structures have been shown to be implicated in respiratory and cardiac rate regulation. We discuss here the potential mechanisms underlying the fatal process, with a description of cerebellar actions likely failing in that SUDEP process. |
| format | Article |
| id | doaj-art-ab5a44488e0848b68c399551a77cdf9a |
| institution | OA Journals |
| issn | 1678-4227 |
| language | English |
| publishDate | 2011-08-01 |
| publisher | Thieme Revinter Publicações |
| record_format | Article |
| series | Arquivos de Neuro-Psiquiatria |
| spelling | doaj-art-ab5a44488e0848b68c399551a77cdf9a2025-08-20T01:59:38ZengThieme Revinter PublicaçõesArquivos de Neuro-Psiquiatria1678-42272011-08-0169470771010.1590/S0004-282X2011000500024S0004-282X2011000500024Sudden death in a child with epilepsy: potential cerebellar mechanisms?Fulvio A. Scorza0Vera C. Terra1Ricardo M. Arida2Américo C. Sakamoto3Ronald M. Harper4Universidade Federal de São PauloUniversidade de São PauloUniversidade Federal de São PauloUniversidade de São PauloUniversity of CaliforniaEpilepsy is the most common neurological disorder in humans. People with epilepsy are more likely to die prematurely than those without epilepsy, with the most common epilepsy-related category of death being sudden unexpected death in epilepsy (SUDEP). The central mechanisms underlying the fatal process remain unclear, but cardiac and respiratory mechanisms appear to be involved. Recently, cerebellar, thalamic, basal ganglia and limbic brain structures have been shown to be implicated in respiratory and cardiac rate regulation. We discuss here the potential mechanisms underlying the fatal process, with a description of cerebellar actions likely failing in that SUDEP process.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2011000500024&lng=en&tlng=enSUDEPepilepsiacerebelomecanismos respiratórioscrises |
| spellingShingle | Fulvio A. Scorza Vera C. Terra Ricardo M. Arida Américo C. Sakamoto Ronald M. Harper Sudden death in a child with epilepsy: potential cerebellar mechanisms? Arquivos de Neuro-Psiquiatria SUDEP epilepsia cerebelo mecanismos respiratórios crises |
| title | Sudden death in a child with epilepsy: potential cerebellar mechanisms? |
| title_full | Sudden death in a child with epilepsy: potential cerebellar mechanisms? |
| title_fullStr | Sudden death in a child with epilepsy: potential cerebellar mechanisms? |
| title_full_unstemmed | Sudden death in a child with epilepsy: potential cerebellar mechanisms? |
| title_short | Sudden death in a child with epilepsy: potential cerebellar mechanisms? |
| title_sort | sudden death in a child with epilepsy potential cerebellar mechanisms |
| topic | SUDEP epilepsia cerebelo mecanismos respiratórios crises |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2011000500024&lng=en&tlng=en |
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