Antibiotic-associated diarrhea: state-of-the-art
The aim of review. To analyse modern concepts on antibiotic-associated diarrhea, to determine its place in the pattern of total morbidity.Key points. Wide antibiotic application in all sections of medicine along with beneficial action has series of essential side effects, including antibiotic-associ...
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| Format: | Article |
| Language: | Russian |
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Gastro LLC
2014-11-01
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| Series: | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
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| Online Access: | https://www.gastro-j.ru/jour/article/view/1144 |
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| _version_ | 1823860069564940288 |
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| author | D. V. Piliev S. I. Achkasov T. K. Korneva O. I. Sushkov |
| author_facet | D. V. Piliev S. I. Achkasov T. K. Korneva O. I. Sushkov |
| author_sort | D. V. Piliev |
| collection | DOAJ |
| description | The aim of review. To analyse modern concepts on antibiotic-associated diarrhea, to determine its place in the pattern of total morbidity.Key points. Wide antibiotic application in all sections of medicine along with beneficial action has series of essential side effects, including antibiotic-associated diarrhea. Its extreme and most severe manifestation is pseudomembranous colitis, caused by toxin-producing Clostridium difficile strains. This etiological agent in modern world has got significant association with hospitals and assisted-care facilities, therefore it can spread in out-patient conditions as well at the present time. Mutations resulting in antibiotic resistance, increasing toxin production or promoting sporulation, considerably increase virulence and prevalence of these opportunistic microorganisms.Conclusion. The further studies on development of effective prophylactic and treatment methods of antibiotic-associated diarrhea are required, especially for most severe complication — pseudomembranous colitis. It is necessary to limit application of antibiotics, develop strict indications to their application. |
| format | Article |
| id | doaj-art-ab55b3b8f29143ed9c10b2c30bc807fc |
| institution | Kabale University |
| issn | 1382-4376 2658-6673 |
| language | Russian |
| publishDate | 2014-11-01 |
| publisher | Gastro LLC |
| record_format | Article |
| series | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| spelling | doaj-art-ab55b3b8f29143ed9c10b2c30bc807fc2025-02-10T16:14:39ZrusGastro LLCРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии1382-43762658-66732014-11-012455462739Antibiotic-associated diarrhea: state-of-the-artD. V. Piliev0S. I. Achkasov1T. K. Korneva2O. I. Sushkov3Federal state-funded institution «State Scientific Center of Coloproctology» Ministry of heathcare of the Russian FederationFederal state-funded institution «State Scientific Center of Coloproctology» Ministry of heathcare of the Russian FederationFederal state-funded institution «State Scientific Center of Coloproctology» Ministry of heathcare of the Russian FederationFederal state-funded institution «State Scientific Center of Coloproctology» Ministry of heathcare of the Russian FederationThe aim of review. To analyse modern concepts on antibiotic-associated diarrhea, to determine its place in the pattern of total morbidity.Key points. Wide antibiotic application in all sections of medicine along with beneficial action has series of essential side effects, including antibiotic-associated diarrhea. Its extreme and most severe manifestation is pseudomembranous colitis, caused by toxin-producing Clostridium difficile strains. This etiological agent in modern world has got significant association with hospitals and assisted-care facilities, therefore it can spread in out-patient conditions as well at the present time. Mutations resulting in antibiotic resistance, increasing toxin production or promoting sporulation, considerably increase virulence and prevalence of these opportunistic microorganisms.Conclusion. The further studies on development of effective prophylactic and treatment methods of antibiotic-associated diarrhea are required, especially for most severe complication — pseudomembranous colitis. It is necessary to limit application of antibiotics, develop strict indications to their application.https://www.gastro-j.ru/jour/article/view/1144antibiotic-associated diarrheapseudomembranous colitisantibioticsprobioticsprophylaxistreatment |
| spellingShingle | D. V. Piliev S. I. Achkasov T. K. Korneva O. I. Sushkov Antibiotic-associated diarrhea: state-of-the-art Российский журнал гастроэнтерологии, гепатологии, колопроктологии antibiotic-associated diarrhea pseudomembranous colitis antibiotics probiotics prophylaxis treatment |
| title | Antibiotic-associated diarrhea: state-of-the-art |
| title_full | Antibiotic-associated diarrhea: state-of-the-art |
| title_fullStr | Antibiotic-associated diarrhea: state-of-the-art |
| title_full_unstemmed | Antibiotic-associated diarrhea: state-of-the-art |
| title_short | Antibiotic-associated diarrhea: state-of-the-art |
| title_sort | antibiotic associated diarrhea state of the art |
| topic | antibiotic-associated diarrhea pseudomembranous colitis antibiotics probiotics prophylaxis treatment |
| url | https://www.gastro-j.ru/jour/article/view/1144 |
| work_keys_str_mv | AT dvpiliev antibioticassociateddiarrheastateoftheart AT siachkasov antibioticassociateddiarrheastateoftheart AT tkkorneva antibioticassociateddiarrheastateoftheart AT oisushkov antibioticassociateddiarrheastateoftheart |