Statin effects on the lipidome: Predicting statin usage and implications for cardiovascular risk prediction

Statin therapy is a highly successful and cost-effective strategy for the prevention and treatment of cardiovascular diseases (CVD). Adjusting for statin usage is crucial when exploring the association of the lipidome with CVD to avoid erroneous conclusions. However, practical challenges arise in re...

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Main Authors:	Changyu Yi, Kevin Huynh, Yvette Schooneveldt, Gavriel Olshansky, Amy Liang, Tingting Wang, Habtamu B. Beyene, Aleksandar Dakic, Jingqin Wu, Michelle Cinel, Natalie A. Mellett, Gerald F. Watts, Joseph Hung, Jennie Hui, John Beilby, Joanne E. Curran, John Blangero, Eric K. Moses, John Simes, Andrew M. Tonkin, Leonard Kritharides, David Sullivan, Jonathan E. Shaw, Dianna J. Magliano, Agus Salim, Corey Giles, Peter J. Meikle, A. Tonkin, P. Aylward, D. Colquhoun, P. Glasziou, P. Harris, D. Hunt, A. Keech, S. MacMahon, P. Magnus, D. Newel, P. Nestel, N. Sharpe, J. Shaw, R.J. Simes, P. Thompson, A. Thomson, M. West, H. White, S. Simes, W. Hague, S. Caleo, J. Hall, A. Martin, S. Mulray, P. Barter, L. Beilin, R. Collins, J. McNeil, P. Meier, H. Willimott, D. Smithers, P. Wallace, J. Baker, M. Hobbs, D. Sullivan, N. Anderson, G. Hankey, J. Watson, M. Arulchelvam, S. Chup, J. Daly, J. Hanna, A. Leach, M. Lee, J. Loughhead, H. Lundie-Jenkin, J. Morrison, S. Netting, A. Nguyen, H. Pater, R. Philip, G. Pinna, D. Rattos, S. Ryerson, V. Sazhin, R. Walsh, A. Clague, M. Mackie, J. Yallop, K. Boss, M. Whiting, M. Shepard, J. Leach, M. Gandy, J. Joughin, J. Seabrook, R. Abraham, J. Allen, F. Bates, I. Beinart, E. Breed, D. Brown, N. Bunyan, D. Calvert, T. Campbell, D. Condon-Paoloni, B. Conway, L. Coupland, J. Crowe, N. Cunio, B. Cuthbert, N. Cuthbert, S. D’Arcy, P. Davidson, B. Dwyer, J. England, C. Friend, G. Fulcher, S. Grant, K. Hellestrand, M. Kava, L. Kritharides, D. McGill, H. McKee, A. McLean, M. Neaverson, G. Nelson, M. O’Neill, C. Onuma, F. O’Reilly, A. Owensby, D. Owensby, J. Padley, G. Parnell, S. Paterson, C. Pawsey, R. Portley, K. Quinn, D. Ramsay, M. Russell, J. Ryan, B. Sambrook, L. Shields, J. Silberberg, S. Sinclair, P. Taverner, D. Taylor, M. Taylor, M. Threlfall, J. Turner, A. Viles, J. Waites, R. Walker, W. Walsh, K. Wee, P. West, R. Wikramanayake, D. Wilcken, J. Woods, R.K. Barnett, Z. Bogetic, H. Briggs, A. Broughton, L. Brown, A. Buncle, P. Calafiore, L. Carrick, Y. Cavenett, L. Champness, R. Clark, H. Connor, J. Counsell, J. Deague, G. Derwent-Smith, A. Driscoll, B. Feldtmann, L. Fisher, B. Forge, A. Hamer, H. Harrap, S. Hodgens, M. Hooten, J. Hurley, B. Jackson, J. Johns, J. Krafchek, H. Larwill, I. Lyall, S. Marks, M. Martin, B. Mason, J. McCabe, C. Medley, L. Morgan, L. Mullan, D. Ogilvy, G. Phelps, P. Phillips, H. Prendergast, D. Rose, G. Rudge, W. Ryan, M. Sallaberger, G. Savige, B. Sia, A. Soward, C. Steinfort, K. Tankard, J. Tippett, B. Tyack, J. Voukelatis, M. Wahlqvist, N. Walker, S. Whitten, R. Yee, M. Zanoni, R. Ziffer, K. Anderson, G. Aroney, C. Atkinson, K. Boyd, R. Bradfield, G. Cameron, D. Careless, A. Carle, P. Carroll, T. Carruthers, D. Chaseling, B. Cooke, S. Coverdale, B. Currie, M. d’Emden, F. Ekin, R. Elder, T. Elsley, L. Ferry, C. Gnanaharan, K. Graham, K. Gunawardane, C. Hadfield, C. Halliday, R. Halliday, A. Heyworth, B. Hicks, P. Hicks, T. Htut, L. Hughes, J. Humphries, H. LeGood, J. Nye, D. O’Brien, G. Real, K. Roberts, L. RossLee, J. Sampson, I. Scott, H. Smith, V. Smith-Orr, Y. Tan, B. Wicks, J. Wicks, S. Woodhouse, J. Bradley, L. Callaway, A. Calvert, J. Crettenden, A. Dufek, B. Dunn, C. Dunphy, D. Gow, I. Hamilton-Craig, K. Herewane, S. Keynes, L. McLeay, R. McLeay, L. Ng, C. Thomas, P. Tideman, L. Wilson, R. Yeend, C. Zhang, Y. Zhang, P. Bradshaw, M. Brooks, R. Burton, J. Garrett, K. Gotch-Martin, J. Hargan, B. Hockings, G. Lane, S. Ross, R. Cutforth, D. D’Silva, W. Hitchener, V. Kimber, G. Kirkland, P. Neid, R. Parkes, B. Singh, C. Singh, M. Smith, S. Smith, M. Templer, N. Whitehouse, R. Allen-Narker, R. Anandaraja, S. Anandaraja, P. Barclay, S. Baskaranathan, P. Bridgman, J. Brown, J. Bruning, J. Calton, M. Clark, D. Clarke, T. Cook, R. Coxon, M. Denton, A. Doone, R. Easthope, J. Elliott, C. Ellis, P. FosterPratt, C. Frenneux, M. Frenneux, D. Friedlander, D. Fry, L. Gibson, M. Gluyas, A. Hall, K. Hall, H. Hart, P. Healy, J. Hedley, P. Heuser, H. Ikram, D. Jardine, J. Kenyon, H. King, T. Kirk, T. Lawson, P. Leslie, G. Lewis, E. Low, R. Luke, S. Mann, D. McClean, D. McHaffie, L. Nairn, H. Patel, L. Pearce, K. Ramanathan, R. Rankin, J. Reddy, S. Reuben, R. Ronaldson, D. Roy, H. Roy, P. Scobie, D. Scott, J. Scott, K. Skjellerup, R. Stewart, D. Walters, T. Wilkins, A. Vitanachy, P. Wright, A. Zambanini
Format:	Article
Language:	English
Published:	Elsevier 2025-05-01
Series:	Journal of Lipid Research
Subjects:	lipidomics cardiovascular disease statins regularized linear models
Online Access:	http://www.sciencedirect.com/science/article/pii/S0022227525000604
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_version_	1850277674923065344
author	Changyu Yi Kevin Huynh Yvette Schooneveldt Gavriel Olshansky Amy Liang Tingting Wang Habtamu B. Beyene Aleksandar Dakic Jingqin Wu Michelle Cinel Natalie A. Mellett Gerald F. Watts Joseph Hung Jennie Hui John Beilby Joanne E. Curran John Blangero Eric K. Moses John Simes Andrew M. Tonkin Leonard Kritharides David Sullivan Jonathan E. Shaw Dianna J. Magliano Agus Salim Corey Giles Peter J. Meikle A. Tonkin P. Aylward D. Colquhoun P. Glasziou P. Harris D. Hunt A. Keech S. MacMahon P. Magnus D. Newel P. Nestel N. Sharpe J. Shaw R.J. Simes P. Thompson A. Thomson M. West H. White A. Thomson S. Simes D. Colquhoun W. Hague S. MacMahon R.J. Simes R.J. Simes P. Glasziou S. Caleo J. Hall A. Martin S. Mulray P. Barter L. Beilin R. Collins J. McNeil P. Meier H. Willimott P. Harris W. Hague D. Smithers A. Tonkin P. Wallace H. Willimott D. Hunt J. Baker P. Aylward P. Harris M. Hobbs P. Thompson N. Sharpe D. Hunt M. West P. Thompson H. White P. Aylward D. Colquhoun D. Sullivan A. Keech P. Thompson S. MacMahon A. Tonkin M. West H. White N. Anderson G. Hankey R.J. Simes S. Simes J. Watson R.J. Simes N. Sharpe A. Thomson A. Tonkin H. White W. Hague J. Baker M. Arulchelvam S. Chup J. Daly J. Hanna A. Leach M. Lee J. Loughhead H. Lundie-Jenkin J. Morrison A. Martin S. Mulray S. Netting A. Nguyen H. Pater R. Philip G. Pinna D. Rattos S. Ryerson V. Sazhin S. Simes R. Walsh A. Keech R.J. Simes A. Clague M. Mackie J. Yallop K. Boss S. MacMahon M. Whiting M. Shepard J. Leach M. Gandy J. Joughin J. Seabrook R. Abraham J. Allen F. Bates I. Beinart E. Breed D. Brown N. Bunyan D. Calvert T. Campbell D. Condon-Paoloni B. Conway L. Coupland J. Crowe N. Cunio B. Cuthbert N. Cuthbert S. D’Arcy P. Davidson B. Dwyer J. England C. Friend G. Fulcher S. Grant K. Hellestrand M. Kava L. Kritharides D. McGill H. McKee A. McLean M. Neaverson G. Nelson M. O’Neill C. Onuma F. O’Reilly A. Owensby D. Owensby J. Padley G. Parnell S. Paterson C. Pawsey R. Portley K. Quinn D. Ramsay M. Russell J. Ryan B. Sambrook L. Shields J. Silberberg S. Sinclair D. Sullivan P. Taverner D. Taylor M. Taylor M. Threlfall J. Turner A. Viles J. Waites R. Walker W. Walsh K. Wee P. West R. Wikramanayake D. Wilcken J. Woods R.K. Barnett Z. Bogetic H. Briggs A. Broughton L. Brown A. Buncle P. Calafiore L. Carrick Y. Cavenett L. Champness R. Clark H. Connor J. Counsell J. Deague G. Derwent-Smith A. Driscoll B. Feldtmann L. Fisher B. Forge A. Hamer H. Harrap S. Hodgens M. Hooten J. Hurley B. Jackson J. Johns J. Krafchek H. Larwill I. Lyall S. Marks M. Martin B. Mason J. McCabe C. Medley L. Morgan L. Mullan D. Ogilvy G. Phelps P. Phillips H. Prendergast D. Rose G. Rudge W. Ryan M. Sallaberger G. Savige B. Sia A. Soward C. Steinfort K. Tankard J. Tippett B. Tyack J. Voukelatis M. Wahlqvist N. Walker S. Whitten R. Yee M. Zanoni R. Ziffer K. Anderson G. Aroney C. Atkinson K. Boyd R. Bradfield G. Cameron D. Careless A. Carle P. Carroll T. Carruthers D. Chaseling B. Cooke S. Coverdale B. Currie M. d’Emden F. Ekin R. Elder T. Elsley L. Ferry C. Gnanaharan K. Graham K. Gunawardane C. Hadfield C. Halliday R. Halliday A. Heyworth B. Hicks P. Hicks T. Htut L. Hughes J. Humphries H. LeGood J. Nye D. O’Brien G. Real K. Roberts L. RossLee J. Sampson I. Scott H. Smith V. Smith-Orr Y. Tan B. Wicks J. Wicks S. Woodhouse J. Bradley L. Callaway A. Calvert J. Crettenden A. Dufek B. Dunn C. Dunphy D. Gow I. Hamilton-Craig K. Herewane S. Keynes L. McLeay R. McLeay L. Ng C. Thomas P. Tideman L. Wilson R. Yeend C. Zhang Y. Zhang P. Bradshaw M. Brooks R. Burton J. Garrett K. Gotch-Martin J. Hargan B. Hockings G. Lane S. Ross R. Cutforth D. D’Silva W. Hitchener V. Kimber G. Kirkland P. Neid R. Parkes B. Singh C. Singh M. Smith S. Smith M. Templer N. Whitehouse R. Allen-Narker R. Anandaraja S. Anandaraja P. Barclay S. Baskaranathan P. Bridgman J. Brown J. Bruning J. Calton A. Clague M. Clark D. Clarke T. Cook R. Coxon M. Denton A. Doone R. Easthope J. Elliott C. Ellis P. FosterPratt C. Frenneux M. Frenneux D. Friedlander D. Fry L. Gibson M. Gluyas A. Hall K. Hall A. Hamer H. Hart P. Healy J. Hedley P. Heuser H. Ikram D. Jardine J. Kenyon H. King T. Kirk T. Lawson P. Leslie G. Lewis E. Low R. Luke S. Mann D. McClean D. McHaffie L. Nairn H. Patel L. Pearce K. Ramanathan R. Rankin J. Reddy S. Reuben R. Ronaldson D. Roy H. Roy P. Scobie D. Scott J. Scott K. Skjellerup R. Stewart D. Walters T. Wilkins A. Vitanachy P. Wright A. Zambanini
author_facet	Changyu Yi Kevin Huynh Yvette Schooneveldt Gavriel Olshansky Amy Liang Tingting Wang Habtamu B. Beyene Aleksandar Dakic Jingqin Wu Michelle Cinel Natalie A. Mellett Gerald F. Watts Joseph Hung Jennie Hui John Beilby Joanne E. Curran John Blangero Eric K. Moses John Simes Andrew M. Tonkin Leonard Kritharides David Sullivan Jonathan E. Shaw Dianna J. Magliano Agus Salim Corey Giles Peter J. Meikle A. Tonkin P. Aylward D. Colquhoun P. Glasziou P. Harris D. Hunt A. Keech S. MacMahon P. Magnus D. Newel P. Nestel N. Sharpe J. Shaw R.J. Simes P. Thompson A. Thomson M. West H. White A. Thomson S. Simes D. Colquhoun W. Hague S. MacMahon R.J. Simes R.J. Simes P. Glasziou S. Caleo J. Hall A. Martin S. Mulray P. Barter L. Beilin R. Collins J. McNeil P. Meier H. Willimott P. Harris W. Hague D. Smithers A. Tonkin P. Wallace H. Willimott D. Hunt J. Baker P. Aylward P. Harris M. Hobbs P. Thompson N. Sharpe D. Hunt M. West P. Thompson H. White P. Aylward D. Colquhoun D. Sullivan A. Keech P. Thompson S. MacMahon A. Tonkin M. West H. White N. Anderson G. Hankey R.J. Simes S. Simes J. Watson R.J. Simes N. Sharpe A. Thomson A. Tonkin H. White W. Hague J. Baker M. Arulchelvam S. Chup J. Daly J. Hanna A. Leach M. Lee J. Loughhead H. Lundie-Jenkin J. Morrison A. Martin S. Mulray S. Netting A. Nguyen H. Pater R. Philip G. Pinna D. Rattos S. Ryerson V. Sazhin S. Simes R. Walsh A. Keech R.J. Simes A. Clague M. Mackie J. Yallop K. Boss S. MacMahon M. Whiting M. Shepard J. Leach M. Gandy J. Joughin J. Seabrook R. Abraham J. Allen F. Bates I. Beinart E. Breed D. Brown N. Bunyan D. Calvert T. Campbell D. Condon-Paoloni B. Conway L. Coupland J. Crowe N. Cunio B. Cuthbert N. Cuthbert S. D’Arcy P. Davidson B. Dwyer J. England C. Friend G. Fulcher S. Grant K. Hellestrand M. Kava L. Kritharides D. McGill H. McKee A. McLean M. Neaverson G. Nelson M. O’Neill C. Onuma F. O’Reilly A. Owensby D. Owensby J. Padley G. Parnell S. Paterson C. Pawsey R. Portley K. Quinn D. Ramsay M. Russell J. Ryan B. Sambrook L. Shields J. Silberberg S. Sinclair D. Sullivan P. Taverner D. Taylor M. Taylor M. Threlfall J. Turner A. Viles J. Waites R. Walker W. Walsh K. Wee P. West R. Wikramanayake D. Wilcken J. Woods R.K. Barnett Z. Bogetic H. Briggs A. Broughton L. Brown A. Buncle P. Calafiore L. Carrick Y. Cavenett L. Champness R. Clark H. Connor J. Counsell J. Deague G. Derwent-Smith A. Driscoll B. Feldtmann L. Fisher B. Forge A. Hamer H. Harrap S. Hodgens M. Hooten J. Hurley B. Jackson J. Johns J. Krafchek H. Larwill I. Lyall S. Marks M. Martin B. Mason J. McCabe C. Medley L. Morgan L. Mullan D. Ogilvy G. Phelps P. Phillips H. Prendergast D. Rose G. Rudge W. Ryan M. Sallaberger G. Savige B. Sia A. Soward C. Steinfort K. Tankard J. Tippett B. Tyack J. Voukelatis M. Wahlqvist N. Walker S. Whitten R. Yee M. Zanoni R. Ziffer K. Anderson G. Aroney C. Atkinson K. Boyd R. Bradfield G. Cameron D. Careless A. Carle P. Carroll T. Carruthers D. Chaseling B. Cooke S. Coverdale B. Currie M. d’Emden F. Ekin R. Elder T. Elsley L. Ferry C. Gnanaharan K. Graham K. Gunawardane C. Hadfield C. Halliday R. Halliday A. Heyworth B. Hicks P. Hicks T. Htut L. Hughes J. Humphries H. LeGood J. Nye D. O’Brien G. Real K. Roberts L. RossLee J. Sampson I. Scott H. Smith V. Smith-Orr Y. Tan B. Wicks J. Wicks S. Woodhouse J. Bradley L. Callaway A. Calvert J. Crettenden A. Dufek B. Dunn C. Dunphy D. Gow I. Hamilton-Craig K. Herewane S. Keynes L. McLeay R. McLeay L. Ng C. Thomas P. Tideman L. Wilson R. Yeend C. Zhang Y. Zhang P. Bradshaw M. Brooks R. Burton J. Garrett K. Gotch-Martin J. Hargan B. Hockings G. Lane S. Ross R. Cutforth D. D’Silva W. Hitchener V. Kimber G. Kirkland P. Neid R. Parkes B. Singh C. Singh M. Smith S. Smith M. Templer N. Whitehouse R. Allen-Narker R. Anandaraja S. Anandaraja P. Barclay S. Baskaranathan P. Bridgman J. Brown J. Bruning J. Calton A. Clague M. Clark D. Clarke T. Cook R. Coxon M. Denton A. Doone R. Easthope J. Elliott C. Ellis P. FosterPratt C. Frenneux M. Frenneux D. Friedlander D. Fry L. Gibson M. Gluyas A. Hall K. Hall A. Hamer H. Hart P. Healy J. Hedley P. Heuser H. Ikram D. Jardine J. Kenyon H. King T. Kirk T. Lawson P. Leslie G. Lewis E. Low R. Luke S. Mann D. McClean D. McHaffie L. Nairn H. Patel L. Pearce K. Ramanathan R. Rankin J. Reddy S. Reuben R. Ronaldson D. Roy H. Roy P. Scobie D. Scott J. Scott K. Skjellerup R. Stewart D. Walters T. Wilkins A. Vitanachy P. Wright A. Zambanini
author_sort	Changyu Yi
collection	DOAJ
description	Statin therapy is a highly successful and cost-effective strategy for the prevention and treatment of cardiovascular diseases (CVD). Adjusting for statin usage is crucial when exploring the association of the lipidome with CVD to avoid erroneous conclusions. However, practical challenges arise in real-world scenarios due to the frequent absence of statin usage information. To address this limitation, we demonstrate that statin usage can be accurately predicted using lipidomic data. Using three large population datasets and a longitudinal clinical study, we show that lipidomic-based statin prediction models exhibit high prediction accuracy in external validation. Furthermore, we introduce a re-weighted model, designed to overcome a ubiquitous limitation of prediction models, namely the need for predictor alignment between training and target data. We demonstrated that the re-weighted models achieved comparable prediction accuracy to ad hoc models which use the aligned predictor between training and target data. This innovation holds promise for significantly enhancing the transferability of statin prediction and other ‘omics prediction models, especially in situations where predictor alignment is incomplete. Our statin prediction model now allows for the inclusion of statin usage in lipidomic analyses of cohorts even where statin use is not available, improving the interpretability of the resulting analyses.
format	Article
id	doaj-art-ab544963e7b6430a9dcf345b05ab5315
institution	OA Journals
issn	0022-2275
language	English
publishDate	2025-05-01
publisher	Elsevier
record_format	Article
series	Journal of Lipid Research
spelling	doaj-art-ab544963e7b6430a9dcf345b05ab53152025-08-20T01:49:47ZengElsevierJournal of Lipid Research0022-22752025-05-0166510080010.1016/j.jlr.2025.100800Statin effects on the lipidome: Predicting statin usage and implications for cardiovascular risk predictionChangyu Yi0Kevin Huynh1Yvette Schooneveldt2Gavriel Olshansky3Amy Liang4Tingting Wang5Habtamu B. Beyene6Aleksandar Dakic7Jingqin Wu8Michelle Cinel9Natalie A. Mellett10Gerald F. Watts11Joseph Hung12Jennie Hui13John Beilby14Joanne E. Curran15John Blangero16Eric K. Moses17John Simes18Andrew M. Tonkin19Leonard Kritharides20David Sullivan21Jonathan E. Shaw22Dianna J. Magliano23Agus Salim24Corey Giles25Peter J. Meikle26A. TonkinP. AylwardD. ColquhounP. GlasziouP. HarrisD. HuntA. KeechS. MacMahonP. MagnusD. NewelP. NestelN. SharpeJ. ShawR.J. SimesP. ThompsonA. ThomsonM. WestH. WhiteA. ThomsonS. SimesD. ColquhounW. HagueS. MacMahonR.J. SimesR.J. SimesP. GlasziouS. CaleoJ. HallA. MartinS. MulrayP. BarterL. BeilinR. CollinsJ. McNeilP. MeierH. WillimottP. HarrisW. HagueD. SmithersA. TonkinP. WallaceH. WillimottD. HuntJ. BakerP. AylwardP. HarrisM. HobbsP. ThompsonN. SharpeD. HuntM. WestP. ThompsonH. WhiteP. AylwardD. ColquhounD. SullivanA. KeechP. ThompsonS. MacMahonA. TonkinM. WestH. WhiteN. AndersonG. HankeyR.J. SimesS. SimesJ. WatsonR.J. SimesN. SharpeA. ThomsonA. TonkinH. WhiteW. HagueJ. BakerM. ArulchelvamS. ChupJ. DalyJ. HannaA. LeachM. LeeJ. LoughheadH. Lundie-JenkinJ. MorrisonA. MartinS. MulrayS. NettingA. NguyenH. PaterR. PhilipG. PinnaD. RattosS. RyersonV. SazhinS. SimesR. WalshA. KeechR.J. SimesA. ClagueM. MackieJ. YallopK. BossS. MacMahonM. WhitingM. ShepardJ. LeachM. GandyJ. JoughinJ. SeabrookR. AbrahamJ. AllenF. BatesI. BeinartE. BreedD. BrownN. BunyanD. CalvertT. CampbellD. Condon-PaoloniB. ConwayL. CouplandJ. CroweN. CunioB. CuthbertN. CuthbertS. D’ArcyP. DavidsonB. DwyerJ. EnglandC. FriendG. FulcherS. GrantK. HellestrandM. KavaL. KritharidesD. McGillH. McKeeA. McLeanM. NeaversonG. NelsonM. O’NeillC. OnumaF. O’ReillyA. OwensbyD. OwensbyJ. PadleyG. ParnellS. PatersonC. PawseyR. PortleyK. QuinnD. RamsayM. RussellJ. RyanB. SambrookL. ShieldsJ. SilberbergS. SinclairD. SullivanP. TavernerD. TaylorM. TaylorM. ThrelfallJ. TurnerA. VilesJ. WaitesR. WalkerW. WalshK. WeeP. WestR. WikramanayakeD. WilckenJ. WoodsR.K. BarnettZ. BogeticH. BriggsA. BroughtonL. BrownA. BuncleP. CalafioreL. CarrickY. CavenettL. ChampnessR. ClarkH. ConnorJ. CounsellJ. DeagueG. Derwent-SmithA. DriscollB. FeldtmannL. FisherB. ForgeA. HamerH. HarrapS. HodgensM. HootenJ. HurleyB. JacksonJ. JohnsJ. KrafchekH. LarwillI. LyallS. MarksM. MartinB. MasonJ. McCabeC. MedleyL. MorganL. MullanD. OgilvyG. PhelpsP. PhillipsH. PrendergastD. RoseG. RudgeW. RyanM. SallabergerG. SavigeB. SiaA. SowardC. SteinfortK. TankardJ. TippettB. TyackJ. VoukelatisM. WahlqvistN. WalkerS. WhittenR. YeeM. ZanoniR. ZifferK. AndersonG. AroneyC. AtkinsonK. BoydR. BradfieldG. CameronD. CarelessA. CarleP. CarrollT. CarruthersD. ChaselingB. CookeS. CoverdaleB. CurrieM. d’EmdenF. EkinR. ElderT. ElsleyL. FerryC. GnanaharanK. GrahamK. GunawardaneC. HadfieldC. HallidayR. HallidayA. HeyworthB. HicksP. HicksT. HtutL. HughesJ. HumphriesH. LeGoodJ. NyeD. O’BrienG. RealK. RobertsL. RossLeeJ. SampsonI. ScottH. SmithV. Smith-OrrY. TanB. WicksJ. WicksS. WoodhouseJ. BradleyL. CallawayA. CalvertJ. CrettendenA. DufekB. DunnC. DunphyD. GowI. Hamilton-CraigK. HerewaneS. KeynesL. McLeayR. McLeayL. NgC. ThomasP. TidemanL. WilsonR. YeendC. ZhangY. ZhangP. BradshawM. BrooksR. BurtonJ. GarrettK. Gotch-MartinJ. HarganB. HockingsG. LaneS. RossR. CutforthD. D’SilvaW. HitchenerV. KimberG. KirklandP. NeidR. ParkesB. SinghC. SinghM. SmithS. SmithM. TemplerN. WhitehouseR. Allen-NarkerR. AnandarajaS. AnandarajaP. BarclayS. BaskaranathanP. BridgmanJ. BrownJ. BruningJ. CaltonA. ClagueM. ClarkD. ClarkeT. CookR. CoxonM. DentonA. DooneR. EasthopeJ. ElliottC. EllisP. FosterPrattC. FrenneuxM. FrenneuxD. FriedlanderD. FryL. GibsonM. GluyasA. HallK. HallA. HamerH. HartP. HealyJ. HedleyP. HeuserH. IkramD. JardineJ. KenyonH. KingT. KirkT. LawsonP. LeslieG. LewisE. LowR. LukeS. MannD. McCleanD. McHaffieL. NairnH. PatelL. PearceK. RamanathanR. RankinJ. ReddyS. ReubenR. RonaldsonD. RoyH. RoyP. ScobieD. ScottJ. ScottK. SkjellerupR. StewartD. WaltersT. WilkinsA. VitanachyP. WrightA. ZambaniniDiabetes and Population Health, Baker Heart and Diabetes Institute, Melbourne, Australia; Baker Department of Cardiometabolic Health, Melbourne University, Melbourne, Australia; Baker Department of Cardiovascular Research Translation and Implementation, La Trobe University, Melbourne, AustraliaDiabetes and Population Health, Baker Heart and Diabetes Institute, Melbourne, Australia; Baker Department of Cardiometabolic Health, Melbourne University, Melbourne, Australia; Baker Department of Cardiovascular Research Translation and Implementation, La Trobe University, Melbourne, AustraliaDiabetes and Population Health, Baker Heart and Diabetes Institute, Melbourne, Australia; Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, AustraliaDiabetes and Population Health, Baker Heart and Diabetes Institute, Melbourne, Australia; Baker Department of Cardiometabolic Health, Melbourne University, Melbourne, AustraliaDiabetes and Population Health, Baker Heart and Diabetes Institute, Melbourne, AustraliaDiabetes and Population Health, Baker Heart and Diabetes Institute, Melbourne, Australia; Baker Department of Cardiometabolic Health, Melbourne University, Melbourne, Australia; Baker Department of Cardiovascular Research Translation and Implementation, La Trobe University, Melbourne, AustraliaDiabetes and Population Health, Baker Heart and Diabetes Institute, Melbourne, Australia; Baker Department of Cardiometabolic Health, Melbourne University, Melbourne, Australia; Baker Department of Cardiovascular Research Translation and Implementation, La Trobe University, Melbourne, Australia; Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, AustraliaDiabetes and Population Health, Baker Heart and Diabetes Institute, Melbourne, AustraliaDiabetes and Population Health, Baker Heart and Diabetes Institute, Melbourne, AustraliaDiabetes and Population Health, Baker Heart and Diabetes Institute, Melbourne, AustraliaDiabetes and Population Health, Baker Heart and Diabetes Institute, Melbourne, AustraliaSchool of Medicine, University of Western Australia, Perth, Australia; Lipid Disorders Clinic, Department of Cardiology, Royal Perth Hospital, Perth, AustraliaSchool of Medicine, University of Western Australia, Perth, AustraliaSchool of Biomedical Sciences, University of Western Australia, Perth, Australia; School of Population and Global Health, University of Western Australia, Perth, AustraliaSchool of Biomedical Sciences, University of Western Australia, Perth, AustraliaSouth Texas Diabetes and Obesity Institute, The University of Texas Rio Grande Valley, Brownsville, TX, USASouth Texas Diabetes and Obesity Institute, The University of Texas Rio Grande Valley, Brownsville, TX, USAMenzies Institute for Medical Research, University of Tasmania, Hobart, AustraliaNational Health and Medical Research Council of Australia (NHMRC), Clinical Trials Centre, University of Sydney, Sydney, AustraliaSchool of Public Health and Preventive Medicine, Monash University, Melbourne, AustraliaAtherosclerosis and Vascular Biology Laboratory, ANZAC Medical Research Institute, Sydney, Australia; Concord Repatriation General Hospital, Sydney Local Health District, Sydney, AustraliaNational Health and Medical Research Council of Australia (NHMRC), Clinical Trials Centre, University of Sydney, Sydney, Australia; New South Wales Health Pathology, Sydney, AustraliaDiabetes and Population Health, Baker Heart and Diabetes Institute, Melbourne, Australia; Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Australia; Clinical Diabetes and Epidemiology, Baker Heart and Diabetes Institute, Melbourne, AustraliaDiabetes and Population Health, Baker Heart and Diabetes Institute, Melbourne, Australia; Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, AustraliaDiabetes and Population Health, Baker Heart and Diabetes Institute, Melbourne, Australia; Baker Department of Cardiometabolic Health, Melbourne University, Melbourne, Australia; Melbourne School of Population and Global Health and School of Mathematics and Statistics, The University of Melbourne, Melbourne, AustraliaDiabetes and Population Health, Baker Heart and Diabetes Institute, Melbourne, Australia; Baker Department of Cardiometabolic Health, Melbourne University, Melbourne, Australia; Baker Department of Cardiovascular Research Translation and Implementation, La Trobe University, Melbourne, Australia; For correspondence: Corey Giles; Peter J. MeikleDiabetes and Population Health, Baker Heart and Diabetes Institute, Melbourne, Australia; Baker Department of Cardiometabolic Health, Melbourne University, Melbourne, Australia; Baker Department of Cardiovascular Research Translation and Implementation, La Trobe University, Melbourne, Australia; Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Australia; For correspondence: Corey Giles; Peter J. MeikleStatin therapy is a highly successful and cost-effective strategy for the prevention and treatment of cardiovascular diseases (CVD). Adjusting for statin usage is crucial when exploring the association of the lipidome with CVD to avoid erroneous conclusions. However, practical challenges arise in real-world scenarios due to the frequent absence of statin usage information. To address this limitation, we demonstrate that statin usage can be accurately predicted using lipidomic data. Using three large population datasets and a longitudinal clinical study, we show that lipidomic-based statin prediction models exhibit high prediction accuracy in external validation. Furthermore, we introduce a re-weighted model, designed to overcome a ubiquitous limitation of prediction models, namely the need for predictor alignment between training and target data. We demonstrated that the re-weighted models achieved comparable prediction accuracy to ad hoc models which use the aligned predictor between training and target data. This innovation holds promise for significantly enhancing the transferability of statin prediction and other ‘omics prediction models, especially in situations where predictor alignment is incomplete. Our statin prediction model now allows for the inclusion of statin usage in lipidomic analyses of cohorts even where statin use is not available, improving the interpretability of the resulting analyses.http://www.sciencedirect.com/science/article/pii/S0022227525000604lipidomicscardiovascular diseasestatinsregularized linear models
spellingShingle	Changyu Yi Kevin Huynh Yvette Schooneveldt Gavriel Olshansky Amy Liang Tingting Wang Habtamu B. Beyene Aleksandar Dakic Jingqin Wu Michelle Cinel Natalie A. Mellett Gerald F. Watts Joseph Hung Jennie Hui John Beilby Joanne E. Curran John Blangero Eric K. Moses John Simes Andrew M. Tonkin Leonard Kritharides David Sullivan Jonathan E. Shaw Dianna J. Magliano Agus Salim Corey Giles Peter J. Meikle A. Tonkin P. Aylward D. Colquhoun P. Glasziou P. Harris D. Hunt A. Keech S. MacMahon P. Magnus D. Newel P. Nestel N. Sharpe J. Shaw R.J. Simes P. Thompson A. Thomson M. West H. White A. Thomson S. Simes D. Colquhoun W. Hague S. MacMahon R.J. Simes R.J. Simes P. Glasziou S. Caleo J. Hall A. Martin S. Mulray P. Barter L. Beilin R. Collins J. McNeil P. Meier H. Willimott P. Harris W. Hague D. Smithers A. Tonkin P. Wallace H. Willimott D. Hunt J. Baker P. Aylward P. Harris M. Hobbs P. Thompson N. Sharpe D. Hunt M. West P. Thompson H. White P. Aylward D. Colquhoun D. Sullivan A. Keech P. Thompson S. MacMahon A. Tonkin M. West H. White N. Anderson G. Hankey R.J. Simes S. Simes J. Watson R.J. Simes N. Sharpe A. Thomson A. Tonkin H. White W. Hague J. Baker M. Arulchelvam S. Chup J. Daly J. Hanna A. Leach M. Lee J. Loughhead H. Lundie-Jenkin J. Morrison A. Martin S. Mulray S. Netting A. Nguyen H. Pater R. Philip G. Pinna D. Rattos S. Ryerson V. Sazhin S. Simes R. Walsh A. Keech R.J. Simes A. Clague M. Mackie J. Yallop K. Boss S. MacMahon M. Whiting M. Shepard J. Leach M. Gandy J. Joughin J. Seabrook R. Abraham J. Allen F. Bates I. Beinart E. Breed D. Brown N. Bunyan D. Calvert T. Campbell D. Condon-Paoloni B. Conway L. Coupland J. Crowe N. Cunio B. Cuthbert N. Cuthbert S. D’Arcy P. Davidson B. Dwyer J. England C. Friend G. Fulcher S. Grant K. Hellestrand M. Kava L. Kritharides D. McGill H. McKee A. McLean M. Neaverson G. Nelson M. O’Neill C. Onuma F. O’Reilly A. Owensby D. Owensby J. Padley G. Parnell S. Paterson C. Pawsey R. Portley K. Quinn D. Ramsay M. Russell J. Ryan B. Sambrook L. Shields J. Silberberg S. Sinclair D. Sullivan P. Taverner D. Taylor M. Taylor M. Threlfall J. Turner A. Viles J. Waites R. Walker W. Walsh K. Wee P. West R. Wikramanayake D. Wilcken J. Woods R.K. Barnett Z. Bogetic H. Briggs A. Broughton L. Brown A. Buncle P. Calafiore L. Carrick Y. Cavenett L. Champness R. Clark H. Connor J. Counsell J. Deague G. Derwent-Smith A. Driscoll B. Feldtmann L. Fisher B. Forge A. Hamer H. Harrap S. Hodgens M. Hooten J. Hurley B. Jackson J. Johns J. Krafchek H. Larwill I. Lyall S. Marks M. Martin B. Mason J. McCabe C. Medley L. Morgan L. Mullan D. Ogilvy G. Phelps P. Phillips H. Prendergast D. Rose G. Rudge W. Ryan M. Sallaberger G. Savige B. Sia A. Soward C. Steinfort K. Tankard J. Tippett B. Tyack J. Voukelatis M. Wahlqvist N. Walker S. Whitten R. Yee M. Zanoni R. Ziffer K. Anderson G. Aroney C. Atkinson K. Boyd R. Bradfield G. Cameron D. Careless A. Carle P. Carroll T. Carruthers D. Chaseling B. Cooke S. Coverdale B. Currie M. d’Emden F. Ekin R. Elder T. Elsley L. Ferry C. Gnanaharan K. Graham K. Gunawardane C. Hadfield C. Halliday R. Halliday A. Heyworth B. Hicks P. Hicks T. Htut L. Hughes J. Humphries H. LeGood J. Nye D. O’Brien G. Real K. Roberts L. RossLee J. Sampson I. Scott H. Smith V. Smith-Orr Y. Tan B. Wicks J. Wicks S. Woodhouse J. Bradley L. Callaway A. Calvert J. Crettenden A. Dufek B. Dunn C. Dunphy D. Gow I. Hamilton-Craig K. Herewane S. Keynes L. McLeay R. McLeay L. Ng C. Thomas P. Tideman L. Wilson R. Yeend C. Zhang Y. Zhang P. Bradshaw M. Brooks R. Burton J. Garrett K. Gotch-Martin J. Hargan B. Hockings G. Lane S. Ross R. Cutforth D. D’Silva W. Hitchener V. Kimber G. Kirkland P. Neid R. Parkes B. Singh C. Singh M. Smith S. Smith M. Templer N. Whitehouse R. Allen-Narker R. Anandaraja S. Anandaraja P. Barclay S. Baskaranathan P. Bridgman J. Brown J. Bruning J. Calton A. Clague M. Clark D. Clarke T. Cook R. Coxon M. Denton A. Doone R. Easthope J. Elliott C. Ellis P. FosterPratt C. Frenneux M. Frenneux D. Friedlander D. Fry L. Gibson M. Gluyas A. Hall K. Hall A. Hamer H. Hart P. Healy J. Hedley P. Heuser H. Ikram D. Jardine J. Kenyon H. King T. Kirk T. Lawson P. Leslie G. Lewis E. Low R. Luke S. Mann D. McClean D. McHaffie L. Nairn H. Patel L. Pearce K. Ramanathan R. Rankin J. Reddy S. Reuben R. Ronaldson D. Roy H. Roy P. Scobie D. Scott J. Scott K. Skjellerup R. Stewart D. Walters T. Wilkins A. Vitanachy P. Wright A. Zambanini Statin effects on the lipidome: Predicting statin usage and implications for cardiovascular risk prediction Journal of Lipid Research lipidomics cardiovascular disease statins regularized linear models
title	Statin effects on the lipidome: Predicting statin usage and implications for cardiovascular risk prediction
title_full	Statin effects on the lipidome: Predicting statin usage and implications for cardiovascular risk prediction
title_fullStr	Statin effects on the lipidome: Predicting statin usage and implications for cardiovascular risk prediction
title_full_unstemmed	Statin effects on the lipidome: Predicting statin usage and implications for cardiovascular risk prediction
title_short	Statin effects on the lipidome: Predicting statin usage and implications for cardiovascular risk prediction
title_sort	statin effects on the lipidome predicting statin usage and implications for cardiovascular risk prediction
topic	lipidomics cardiovascular disease statins regularized linear models
url	http://www.sciencedirect.com/science/article/pii/S0022227525000604
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Statin effects on the lipidome: Predicting statin usage and implications for cardiovascular risk prediction

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