Metal Nanomaterials: A Strategy to Combat Drug-Resistant Bacterial Infections
Bacterial infections pose a major challenge today due to the rise of drug resistance in pathogenic bacteria, creating an urgent need for the development of nonantibiotic therapies. Metal nanomaterials are increasingly recognized as promising antibacterial agents due to their unique physical and chem...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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American Association for the Advancement of Science (AAAS)
2025-01-01
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| Series: | Research |
| Online Access: | https://spj.science.org/doi/10.34133/research.0853 |
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| author | Yaran Wang Fan Wu Yijin Ren Yong Liu Henny C. Mei |
| author_facet | Yaran Wang Fan Wu Yijin Ren Yong Liu Henny C. Mei |
| author_sort | Yaran Wang |
| collection | DOAJ |
| description | Bacterial infections pose a major challenge today due to the rise of drug resistance in pathogenic bacteria, creating an urgent need for the development of nonantibiotic therapies. Metal nanomaterials are increasingly recognized as promising antibacterial agents due to their unique physical and chemical properties, which offer strong antibacterial capabilities and broad-spectrum activity against drug-resistant bacteria. Unlike traditional antibacterial therapies, metal nanomaterials rarely induce drug resistance because of their diverse antibacterial mechanisms, which destroy bacteria by directly damaging bacterial cells or generating oxidative stress. Metal nanomaterials have proven effective in treating various drug-resistant bacterial infections. This perspective highlights recent advances in metal nanomaterials for antimicrobial applications. Firstly, bacterial infections and the current dilemma are introduced. Next, recent progress in the antibacterial activity of metal nanomaterials against drug-resistant bacteria is summarized, along with the challenges in their antimicrobial applications. Finally, future prospects and remaining challenges associated with the use of metal nanomaterials to treat drug-resistant bacteria are discussed. |
| format | Article |
| id | doaj-art-ab522da18ac547fdb0946b90e9d6bae4 |
| institution | Kabale University |
| issn | 2639-5274 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | American Association for the Advancement of Science (AAAS) |
| record_format | Article |
| series | Research |
| spelling | doaj-art-ab522da18ac547fdb0946b90e9d6bae42025-08-21T14:11:31ZengAmerican Association for the Advancement of Science (AAAS)Research2639-52742025-01-01810.34133/research.0853Metal Nanomaterials: A Strategy to Combat Drug-Resistant Bacterial InfectionsYaran Wang0Fan Wu1Yijin Ren2Yong Liu3Henny C. Mei4State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Functional Polymer Materials, Ministry of Education, Institute of Polymer Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China.State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Functional Polymer Materials, Ministry of Education, Institute of Polymer Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China.Department of Orthodontics, University of Groningen and University Medical Center Groningen, Groningen, Netherlands.State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Functional Polymer Materials, Ministry of Education, Institute of Polymer Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China.Department of Biomaterials and Biomedical Technology, University of Groningen and University Medical Center Groningen, Groningen, Netherlands.Bacterial infections pose a major challenge today due to the rise of drug resistance in pathogenic bacteria, creating an urgent need for the development of nonantibiotic therapies. Metal nanomaterials are increasingly recognized as promising antibacterial agents due to their unique physical and chemical properties, which offer strong antibacterial capabilities and broad-spectrum activity against drug-resistant bacteria. Unlike traditional antibacterial therapies, metal nanomaterials rarely induce drug resistance because of their diverse antibacterial mechanisms, which destroy bacteria by directly damaging bacterial cells or generating oxidative stress. Metal nanomaterials have proven effective in treating various drug-resistant bacterial infections. This perspective highlights recent advances in metal nanomaterials for antimicrobial applications. Firstly, bacterial infections and the current dilemma are introduced. Next, recent progress in the antibacterial activity of metal nanomaterials against drug-resistant bacteria is summarized, along with the challenges in their antimicrobial applications. Finally, future prospects and remaining challenges associated with the use of metal nanomaterials to treat drug-resistant bacteria are discussed.https://spj.science.org/doi/10.34133/research.0853 |
| spellingShingle | Yaran Wang Fan Wu Yijin Ren Yong Liu Henny C. Mei Metal Nanomaterials: A Strategy to Combat Drug-Resistant Bacterial Infections Research |
| title | Metal Nanomaterials: A Strategy to Combat Drug-Resistant Bacterial Infections |
| title_full | Metal Nanomaterials: A Strategy to Combat Drug-Resistant Bacterial Infections |
| title_fullStr | Metal Nanomaterials: A Strategy to Combat Drug-Resistant Bacterial Infections |
| title_full_unstemmed | Metal Nanomaterials: A Strategy to Combat Drug-Resistant Bacterial Infections |
| title_short | Metal Nanomaterials: A Strategy to Combat Drug-Resistant Bacterial Infections |
| title_sort | metal nanomaterials a strategy to combat drug resistant bacterial infections |
| url | https://spj.science.org/doi/10.34133/research.0853 |
| work_keys_str_mv | AT yaranwang metalnanomaterialsastrategytocombatdrugresistantbacterialinfections AT fanwu metalnanomaterialsastrategytocombatdrugresistantbacterialinfections AT yijinren metalnanomaterialsastrategytocombatdrugresistantbacterialinfections AT yongliu metalnanomaterialsastrategytocombatdrugresistantbacterialinfections AT hennycmei metalnanomaterialsastrategytocombatdrugresistantbacterialinfections |