Use of Metallic Nanoparticles Synthesized from Plant Extracts in Wound Healing—A Review
Wound healing is rarely seen as a problem in healthy individuals; however, under certain pathophysiological conditions, this process can be impaired, leading to the emergence of chronic wounds, which are themselves a serious public health problem. This work aimed to review the most important recent...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-10-01
|
| Series: | Applied Nano |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2673-3501/5/4/14 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850239702081208320 |
|---|---|
| author | Anaís Bezerra de Gusmão Priscilla Barbosa Sales de Albuquerque Ana Carolina de Carvalho Correia |
| author_facet | Anaís Bezerra de Gusmão Priscilla Barbosa Sales de Albuquerque Ana Carolina de Carvalho Correia |
| author_sort | Anaís Bezerra de Gusmão |
| collection | DOAJ |
| description | Wound healing is rarely seen as a problem in healthy individuals; however, under certain pathophysiological conditions, this process can be impaired, leading to the emergence of chronic wounds, which are themselves a serious public health problem. This work aimed to review the most important recent literature on the use of nanoparticles of Ag, Au, and Zn produced from plant extracts and their application as healing agents. To that end, we provide an insight into the pathophysiology of wound healing and the main routes to obtaining metallic nanoparticles. The methodology of synthesis, which is part of the so-called green synthesis, has been the focus of several studies on the use of medicinal plants as a substrate to produce silver, gold, and zinc nanoparticles. Their use as wound healing agents is closely related to their natural antimicrobial, anti-inflammatory, and cicatrizing properties. Finally, we address in vitro and in vivo studies on the efficiency of metallic nanoparticles (MNPs) synthesized from plant extracts and applied to wound healing in different pharmaceutical forms. For instance, the excellent wound contraction rates obtained from silver and gold NPs, respectively, were obtained from <i>Euphorbia milii</i> (92%) and <i>Plectranthus aliciae</i> (almost 97%) extracts in in vivo and in vitro analyses. Based on the satisfactory results, we find that MNPs are a potential therapeutic alternative compared to traditional synthetic healing agents and foresee the production of new pharmaceutical drugs. |
| format | Article |
| id | doaj-art-ab44581923bd4248b8265161d835dcda |
| institution | OA Journals |
| issn | 2673-3501 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Nano |
| spelling | doaj-art-ab44581923bd4248b8265161d835dcda2025-08-20T02:01:05ZengMDPI AGApplied Nano2673-35012024-10-015420522610.3390/applnano5040014Use of Metallic Nanoparticles Synthesized from Plant Extracts in Wound Healing—A ReviewAnaís Bezerra de Gusmão0Priscilla Barbosa Sales de Albuquerque1Ana Carolina de Carvalho Correia2Garanhuns College of Science, Education and Technology, University of Pernambuco, Garanhuns 55294-902, PE, BrazilInstituto de Ciências Biológicas, Universidade de Pernambuco, Rua Arnóbio Marques, 310, Recife 50100-130, PE, BrazilGaranhuns College of Science, Education and Technology, University of Pernambuco, Garanhuns 55294-902, PE, BrazilWound healing is rarely seen as a problem in healthy individuals; however, under certain pathophysiological conditions, this process can be impaired, leading to the emergence of chronic wounds, which are themselves a serious public health problem. This work aimed to review the most important recent literature on the use of nanoparticles of Ag, Au, and Zn produced from plant extracts and their application as healing agents. To that end, we provide an insight into the pathophysiology of wound healing and the main routes to obtaining metallic nanoparticles. The methodology of synthesis, which is part of the so-called green synthesis, has been the focus of several studies on the use of medicinal plants as a substrate to produce silver, gold, and zinc nanoparticles. Their use as wound healing agents is closely related to their natural antimicrobial, anti-inflammatory, and cicatrizing properties. Finally, we address in vitro and in vivo studies on the efficiency of metallic nanoparticles (MNPs) synthesized from plant extracts and applied to wound healing in different pharmaceutical forms. For instance, the excellent wound contraction rates obtained from silver and gold NPs, respectively, were obtained from <i>Euphorbia milii</i> (92%) and <i>Plectranthus aliciae</i> (almost 97%) extracts in in vivo and in vitro analyses. Based on the satisfactory results, we find that MNPs are a potential therapeutic alternative compared to traditional synthetic healing agents and foresee the production of new pharmaceutical drugs.https://www.mdpi.com/2673-3501/5/4/14green synthesismetallic nanoparticlesnanotechnologynatural treatmentplant extractswound healing |
| spellingShingle | Anaís Bezerra de Gusmão Priscilla Barbosa Sales de Albuquerque Ana Carolina de Carvalho Correia Use of Metallic Nanoparticles Synthesized from Plant Extracts in Wound Healing—A Review Applied Nano green synthesis metallic nanoparticles nanotechnology natural treatment plant extracts wound healing |
| title | Use of Metallic Nanoparticles Synthesized from Plant Extracts in Wound Healing—A Review |
| title_full | Use of Metallic Nanoparticles Synthesized from Plant Extracts in Wound Healing—A Review |
| title_fullStr | Use of Metallic Nanoparticles Synthesized from Plant Extracts in Wound Healing—A Review |
| title_full_unstemmed | Use of Metallic Nanoparticles Synthesized from Plant Extracts in Wound Healing—A Review |
| title_short | Use of Metallic Nanoparticles Synthesized from Plant Extracts in Wound Healing—A Review |
| title_sort | use of metallic nanoparticles synthesized from plant extracts in wound healing a review |
| topic | green synthesis metallic nanoparticles nanotechnology natural treatment plant extracts wound healing |
| url | https://www.mdpi.com/2673-3501/5/4/14 |
| work_keys_str_mv | AT anaisbezerradegusmao useofmetallicnanoparticlessynthesizedfromplantextractsinwoundhealingareview AT priscillabarbosasalesdealbuquerque useofmetallicnanoparticlessynthesizedfromplantextractsinwoundhealingareview AT anacarolinadecarvalhocorreia useofmetallicnanoparticlessynthesizedfromplantextractsinwoundhealingareview |