Dynamism, Sensitivity, and Consequences of Mesenchymal and Stem-Like Phenotype of Cancer Cells
There are remarkable similarities in the description of cancer stem cells (CSCs) and cancer cells with mesenchymal phenotype. Both cell types are highly tumorigenic, resistant against common anticancer treatment, and thought to cause metastatic growth. Moreover, cancer cells are able to switch betwe...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2018/4516454 |
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| author | Petra Gener Joaquin Seras-Franzoso Patricia González Callejo Fernanda Andrade Diana Rafael Francesc Martínez Sara Montero Diego Arango Joan Sayós Ibane Abasolo Simó Schwartz |
| author_facet | Petra Gener Joaquin Seras-Franzoso Patricia González Callejo Fernanda Andrade Diana Rafael Francesc Martínez Sara Montero Diego Arango Joan Sayós Ibane Abasolo Simó Schwartz |
| author_sort | Petra Gener |
| collection | DOAJ |
| description | There are remarkable similarities in the description of cancer stem cells (CSCs) and cancer cells with mesenchymal phenotype. Both cell types are highly tumorigenic, resistant against common anticancer treatment, and thought to cause metastatic growth. Moreover, cancer cells are able to switch between CSC and non-CSC phenotypes and vice versa, to ensure the necessary balance within the tumor. Likewise, cancer cells can switch between epithelial and mesenchymal phenotypes via well-described transition (EMT/MET) that is thought to be crucial for tumor propagation. In this review, we discuss whether, and to which extend, the CSCs and mesenchymal cancer cells are overlapping phenomena in terms of mechanisms, origin, and implication for cancer treatment. As well, we describe the dynamism of both phenotypes and involvement of the tumor microenvironment in CSC reversion and in EMT. |
| format | Article |
| id | doaj-art-ab438e8899c942bd90f48cd7b03a8d0f |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-ab438e8899c942bd90f48cd7b03a8d0f2025-08-20T03:39:40ZengWileyStem Cells International1687-966X1687-96782018-01-01201810.1155/2018/45164544516454Dynamism, Sensitivity, and Consequences of Mesenchymal and Stem-Like Phenotype of Cancer CellsPetra Gener0Joaquin Seras-Franzoso1Patricia González Callejo2Fernanda Andrade3Diana Rafael4Francesc Martínez5Sara Montero6Diego Arango7Joan Sayós8Ibane Abasolo9Simó Schwartz10Drug Delivery and Targeting Group, CIBBIM-Nanomedicine, Vall d’Hebron Institut de Recerca (VHIR), Vall d’Hebron Barcelona Hospital Campus, 08035 Barcelona, SpainDrug Delivery and Targeting Group, CIBBIM-Nanomedicine, Vall d’Hebron Institut de Recerca (VHIR), Vall d’Hebron Barcelona Hospital Campus, 08035 Barcelona, SpainDrug Delivery and Targeting Group, CIBBIM-Nanomedicine, Vall d’Hebron Institut de Recerca (VHIR), Vall d’Hebron Barcelona Hospital Campus, 08035 Barcelona, SpainDrug Delivery and Targeting Group, CIBBIM-Nanomedicine, Vall d’Hebron Institut de Recerca (VHIR), Vall d’Hebron Barcelona Hospital Campus, 08035 Barcelona, SpainDrug Delivery and Targeting Group, CIBBIM-Nanomedicine, Vall d’Hebron Institut de Recerca (VHIR), Vall d’Hebron Barcelona Hospital Campus, 08035 Barcelona, SpainDrug Delivery and Targeting Group, CIBBIM-Nanomedicine, Vall d’Hebron Institut de Recerca (VHIR), Vall d’Hebron Barcelona Hospital Campus, 08035 Barcelona, SpainDrug Delivery and Targeting Group, CIBBIM-Nanomedicine, Vall d’Hebron Institut de Recerca (VHIR), Vall d’Hebron Barcelona Hospital Campus, 08035 Barcelona, SpainBiomedical Research in Digestive Tract Tumors, CIBBIM-Nanomedicine, Vall d’Hebron Institut de Recerca, Universitat Autonoma de Barcelona, Barcelona, SpainImmune Regulation and Immunotherapy, CIBBIM-Nanomedicine, Vall d’Hebron Institut de Recerca, Universitat Autonoma de Barcelona, Barcelona, SpainDrug Delivery and Targeting Group, CIBBIM-Nanomedicine, Vall d’Hebron Institut de Recerca (VHIR), Vall d’Hebron Barcelona Hospital Campus, 08035 Barcelona, SpainDrug Delivery and Targeting Group, CIBBIM-Nanomedicine, Vall d’Hebron Institut de Recerca (VHIR), Vall d’Hebron Barcelona Hospital Campus, 08035 Barcelona, SpainThere are remarkable similarities in the description of cancer stem cells (CSCs) and cancer cells with mesenchymal phenotype. Both cell types are highly tumorigenic, resistant against common anticancer treatment, and thought to cause metastatic growth. Moreover, cancer cells are able to switch between CSC and non-CSC phenotypes and vice versa, to ensure the necessary balance within the tumor. Likewise, cancer cells can switch between epithelial and mesenchymal phenotypes via well-described transition (EMT/MET) that is thought to be crucial for tumor propagation. In this review, we discuss whether, and to which extend, the CSCs and mesenchymal cancer cells are overlapping phenomena in terms of mechanisms, origin, and implication for cancer treatment. As well, we describe the dynamism of both phenotypes and involvement of the tumor microenvironment in CSC reversion and in EMT.http://dx.doi.org/10.1155/2018/4516454 |
| spellingShingle | Petra Gener Joaquin Seras-Franzoso Patricia González Callejo Fernanda Andrade Diana Rafael Francesc Martínez Sara Montero Diego Arango Joan Sayós Ibane Abasolo Simó Schwartz Dynamism, Sensitivity, and Consequences of Mesenchymal and Stem-Like Phenotype of Cancer Cells Stem Cells International |
| title | Dynamism, Sensitivity, and Consequences of Mesenchymal and Stem-Like Phenotype of Cancer Cells |
| title_full | Dynamism, Sensitivity, and Consequences of Mesenchymal and Stem-Like Phenotype of Cancer Cells |
| title_fullStr | Dynamism, Sensitivity, and Consequences of Mesenchymal and Stem-Like Phenotype of Cancer Cells |
| title_full_unstemmed | Dynamism, Sensitivity, and Consequences of Mesenchymal and Stem-Like Phenotype of Cancer Cells |
| title_short | Dynamism, Sensitivity, and Consequences of Mesenchymal and Stem-Like Phenotype of Cancer Cells |
| title_sort | dynamism sensitivity and consequences of mesenchymal and stem like phenotype of cancer cells |
| url | http://dx.doi.org/10.1155/2018/4516454 |
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