Paederia scandens extract alleviates obesity via modulating the gut microbiota and serum metabolome disorder
Obesity is increasingly becoming a challenge with China’s economic development. There is an urgent need to identify more affordable methods to combat this condition. Paederia scandens (PS), a cost-effective herbal remedy widely used in China for treating inflammation and pain, shows potential in thi...
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Frontiers Media S.A.
2025-04-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2025.1554537/full |
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| author | Yuanyuan Yang Jinglei Si Jiayuan Mo Jin Li Bin Pan Yi Pan Lihe Jiang Decai Wang Xueping Feng |
| author_facet | Yuanyuan Yang Jinglei Si Jiayuan Mo Jin Li Bin Pan Yi Pan Lihe Jiang Decai Wang Xueping Feng |
| author_sort | Yuanyuan Yang |
| collection | DOAJ |
| description | Obesity is increasingly becoming a challenge with China’s economic development. There is an urgent need to identify more affordable methods to combat this condition. Paederia scandens (PS), a cost-effective herbal remedy widely used in China for treating inflammation and pain, shows potential in this regard. To investigate its anti-obesity mechanisms, we established a high-fat diet (HFD)-induced obesity model in mice. The obese mice subsequently received daily oral gavage of PS extract for 21 consecutive days. Upon the completion of the experiment, blood samples were collected to analyze lipid profiles, including total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL-C), and low-density lipoprotein (LDL-C). Abdominal adipose tissue was subjected to hematoxylin–eosin (HE) staining for histological analysis, while fecal samples underwent 16S rRNA sequencing to assess gut microbiota composition. Our findings revealed that PS supplementation significantly reduced body weight, lipid metabolism biomarkers, and adipocyte size. PS treatment also restored gut microbial diversity, with 19 specific microbial taxa and 25 KEGG pathways identified as potential mediators of its anti-obesity effects. Notably, PS modulated key obesity-associated gut microbiota, including Alistipes, Lachnoclostridium, Odoribacter, Prevotellaceae UCG-001, Rikenellaceae RC9-gut group, and norank_g Bacteroidales S24-7 group. Serum metabolomics analysis implicated L-ascorbic acid, stevioside, allopurinol, and gingerol, along with amino acid and energy metabolism pathways, in the anti-obesity mechanism of PS. These results provide novel theoretical insights into the therapeutic potential of PS for obesity prevention and treatment. |
| format | Article |
| id | doaj-art-ab3b18fd7c86452ba890c39c6c8a310e |
| institution | OA Journals |
| issn | 1664-302X |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj-art-ab3b18fd7c86452ba890c39c6c8a310e2025-08-20T02:12:06ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2025-04-011610.3389/fmicb.2025.15545371554537Paederia scandens extract alleviates obesity via modulating the gut microbiota and serum metabolome disorderYuanyuan Yang0Jinglei Si1Jiayuan Mo2Jin Li3Bin Pan4Yi Pan5Lihe Jiang6Decai Wang7Xueping Feng8School of Basic Medicine, Youjiang Medical University for Nationalities, Baise, ChinaCollege of Animal Science & Technology, Guangxi University, Nanning, ChinaCollege of Animal Science, Anhui Science and Technology University, Chuzhou, ChinaLaboratory Animal Center, Youjiang Medical University for Nationalities, Baise, ChinaLaboratory Animal Center, Youjiang Medical University for Nationalities, Baise, ChinaLaboratory Animal Center, Youjiang Medical University for Nationalities, Baise, ChinaSchool of Basic Medicine, Youjiang Medical University for Nationalities, Baise, ChinaLibrary, Youjiang Medical University for Nationalities, Baise, ChinaSchool of Basic Medicine, Youjiang Medical University for Nationalities, Baise, ChinaObesity is increasingly becoming a challenge with China’s economic development. There is an urgent need to identify more affordable methods to combat this condition. Paederia scandens (PS), a cost-effective herbal remedy widely used in China for treating inflammation and pain, shows potential in this regard. To investigate its anti-obesity mechanisms, we established a high-fat diet (HFD)-induced obesity model in mice. The obese mice subsequently received daily oral gavage of PS extract for 21 consecutive days. Upon the completion of the experiment, blood samples were collected to analyze lipid profiles, including total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL-C), and low-density lipoprotein (LDL-C). Abdominal adipose tissue was subjected to hematoxylin–eosin (HE) staining for histological analysis, while fecal samples underwent 16S rRNA sequencing to assess gut microbiota composition. Our findings revealed that PS supplementation significantly reduced body weight, lipid metabolism biomarkers, and adipocyte size. PS treatment also restored gut microbial diversity, with 19 specific microbial taxa and 25 KEGG pathways identified as potential mediators of its anti-obesity effects. Notably, PS modulated key obesity-associated gut microbiota, including Alistipes, Lachnoclostridium, Odoribacter, Prevotellaceae UCG-001, Rikenellaceae RC9-gut group, and norank_g Bacteroidales S24-7 group. Serum metabolomics analysis implicated L-ascorbic acid, stevioside, allopurinol, and gingerol, along with amino acid and energy metabolism pathways, in the anti-obesity mechanism of PS. These results provide novel theoretical insights into the therapeutic potential of PS for obesity prevention and treatment.https://www.frontiersin.org/articles/10.3389/fmicb.2025.1554537/fullPaederia scandensobesityhigh-fat inducedmicrobesmetabolites |
| spellingShingle | Yuanyuan Yang Jinglei Si Jiayuan Mo Jin Li Bin Pan Yi Pan Lihe Jiang Decai Wang Xueping Feng Paederia scandens extract alleviates obesity via modulating the gut microbiota and serum metabolome disorder Frontiers in Microbiology Paederia scandens obesity high-fat induced microbes metabolites |
| title | Paederia scandens extract alleviates obesity via modulating the gut microbiota and serum metabolome disorder |
| title_full | Paederia scandens extract alleviates obesity via modulating the gut microbiota and serum metabolome disorder |
| title_fullStr | Paederia scandens extract alleviates obesity via modulating the gut microbiota and serum metabolome disorder |
| title_full_unstemmed | Paederia scandens extract alleviates obesity via modulating the gut microbiota and serum metabolome disorder |
| title_short | Paederia scandens extract alleviates obesity via modulating the gut microbiota and serum metabolome disorder |
| title_sort | paederia scandens extract alleviates obesity via modulating the gut microbiota and serum metabolome disorder |
| topic | Paederia scandens obesity high-fat induced microbes metabolites |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2025.1554537/full |
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