Analysis of the APOB Gene and Apolipoprotein B Serum Levels in a Mexican Population with Acute Coronary Syndrome: Association with the Single Nucleotide Variants rs1469513, rs673548, rs676210, and rs1042034
Apolipoprotein B (APOB) is associated with the development of atherosclerosis and consequently in the acute coronary syndrome (ACS) physiopathology. Single number variants (SNVs) in apolipoprotein B gene (APOB) influence over the susceptibility for this syndrome. The aim of this study was to determi...
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Wiley
2022-01-01
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| Series: | Genetics Research |
| Online Access: | http://dx.doi.org/10.1155/2022/4901090 |
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| author | Maricela Aceves-Ramírez Yeminia Valle Fidel Casillas-Muñoz Diana Emilia Martínez-Fernández Brenda Parra-Reyna Víctor Arturo López-Moreno Héctor Enrique Flores-Salinas Emmanuel Valdés-Alvarado José Francisco Muñoz-Valle Texali García-Garduño Jorge Ramón Padilla-Gutiérrez |
| author_facet | Maricela Aceves-Ramírez Yeminia Valle Fidel Casillas-Muñoz Diana Emilia Martínez-Fernández Brenda Parra-Reyna Víctor Arturo López-Moreno Héctor Enrique Flores-Salinas Emmanuel Valdés-Alvarado José Francisco Muñoz-Valle Texali García-Garduño Jorge Ramón Padilla-Gutiérrez |
| author_sort | Maricela Aceves-Ramírez |
| collection | DOAJ |
| description | Apolipoprotein B (APOB) is associated with the development of atherosclerosis and consequently in the acute coronary syndrome (ACS) physiopathology. Single number variants (SNVs) in apolipoprotein B gene (APOB) influence over the susceptibility for this syndrome. The aim of this study was to determine the impact of the rs1469513, rs673548, rs676210, and rs1042034 SNVs and serum levels of APOB in the risk of ACS in a population from western Mexico. We included 300 patients in the group of cases (ACSG) and 300 individuals in the control group (CG). APOB levels were evaluated by immunonephelometry, and SNVs were genotyped with TaqMan probes. We found significant allelic and genotypic differences between groups for rs673548 and rs676210 (OR = 1.33, p=0.030, OR = 2.69, p<0.001) and rs1042034 (OR = 0.50, p=0.037) SNVs. We found a risk haplotype TAGT (OR: 2.14, IC 1.50–3.04, p<0.001). Our findings support a significant risk association between rs673548 and rs676210 variants for ACS; meanwhile, rs1042034 could be considered protective factor in a western Mexican population. Also, in this population, haplotype TAGT may confer 2.14 times a higher risk. APOB serum levels were compared by genotype variants in both groups without any significant statistical difference. |
| format | Article |
| id | doaj-art-ab3959417a2c436cb6c149da98751a42 |
| institution | Kabale University |
| issn | 1469-5073 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Genetics Research |
| spelling | doaj-art-ab3959417a2c436cb6c149da98751a422025-08-20T03:39:40ZengWileyGenetics Research1469-50732022-01-01202210.1155/2022/4901090Analysis of the APOB Gene and Apolipoprotein B Serum Levels in a Mexican Population with Acute Coronary Syndrome: Association with the Single Nucleotide Variants rs1469513, rs673548, rs676210, and rs1042034Maricela Aceves-Ramírez0Yeminia Valle1Fidel Casillas-Muñoz2Diana Emilia Martínez-Fernández3Brenda Parra-Reyna4Víctor Arturo López-Moreno5Héctor Enrique Flores-Salinas6Emmanuel Valdés-Alvarado7José Francisco Muñoz-Valle8Texali García-Garduño9Jorge Ramón Padilla-Gutiérrez10Instituto de Investigación en Ciencias Biomédicas (IICB)Instituto de Investigación en Ciencias Biomédicas (IICB)Instituto de Investigación en Ciencias Biomédicas (IICB)Instituto de Investigación en Ciencias Biomédicas (IICB)Instituto de Investigación en Ciencias Biomédicas (IICB)Especialidad en CardiologíaEspecialidad en CardiologíaInstituto de Investigación en Ciencias Biomédicas (IICB)Instituto de Investigación en Ciencias Biomédicas (IICB)Instituto de Investigación en Ciencias Biomédicas (IICB)Instituto de Investigación en Ciencias Biomédicas (IICB)Apolipoprotein B (APOB) is associated with the development of atherosclerosis and consequently in the acute coronary syndrome (ACS) physiopathology. Single number variants (SNVs) in apolipoprotein B gene (APOB) influence over the susceptibility for this syndrome. The aim of this study was to determine the impact of the rs1469513, rs673548, rs676210, and rs1042034 SNVs and serum levels of APOB in the risk of ACS in a population from western Mexico. We included 300 patients in the group of cases (ACSG) and 300 individuals in the control group (CG). APOB levels were evaluated by immunonephelometry, and SNVs were genotyped with TaqMan probes. We found significant allelic and genotypic differences between groups for rs673548 and rs676210 (OR = 1.33, p=0.030, OR = 2.69, p<0.001) and rs1042034 (OR = 0.50, p=0.037) SNVs. We found a risk haplotype TAGT (OR: 2.14, IC 1.50–3.04, p<0.001). Our findings support a significant risk association between rs673548 and rs676210 variants for ACS; meanwhile, rs1042034 could be considered protective factor in a western Mexican population. Also, in this population, haplotype TAGT may confer 2.14 times a higher risk. APOB serum levels were compared by genotype variants in both groups without any significant statistical difference.http://dx.doi.org/10.1155/2022/4901090 |
| spellingShingle | Maricela Aceves-Ramírez Yeminia Valle Fidel Casillas-Muñoz Diana Emilia Martínez-Fernández Brenda Parra-Reyna Víctor Arturo López-Moreno Héctor Enrique Flores-Salinas Emmanuel Valdés-Alvarado José Francisco Muñoz-Valle Texali García-Garduño Jorge Ramón Padilla-Gutiérrez Analysis of the APOB Gene and Apolipoprotein B Serum Levels in a Mexican Population with Acute Coronary Syndrome: Association with the Single Nucleotide Variants rs1469513, rs673548, rs676210, and rs1042034 Genetics Research |
| title | Analysis of the APOB Gene and Apolipoprotein B Serum Levels in a Mexican Population with Acute Coronary Syndrome: Association with the Single Nucleotide Variants rs1469513, rs673548, rs676210, and rs1042034 |
| title_full | Analysis of the APOB Gene and Apolipoprotein B Serum Levels in a Mexican Population with Acute Coronary Syndrome: Association with the Single Nucleotide Variants rs1469513, rs673548, rs676210, and rs1042034 |
| title_fullStr | Analysis of the APOB Gene and Apolipoprotein B Serum Levels in a Mexican Population with Acute Coronary Syndrome: Association with the Single Nucleotide Variants rs1469513, rs673548, rs676210, and rs1042034 |
| title_full_unstemmed | Analysis of the APOB Gene and Apolipoprotein B Serum Levels in a Mexican Population with Acute Coronary Syndrome: Association with the Single Nucleotide Variants rs1469513, rs673548, rs676210, and rs1042034 |
| title_short | Analysis of the APOB Gene and Apolipoprotein B Serum Levels in a Mexican Population with Acute Coronary Syndrome: Association with the Single Nucleotide Variants rs1469513, rs673548, rs676210, and rs1042034 |
| title_sort | analysis of the apob gene and apolipoprotein b serum levels in a mexican population with acute coronary syndrome association with the single nucleotide variants rs1469513 rs673548 rs676210 and rs1042034 |
| url | http://dx.doi.org/10.1155/2022/4901090 |
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