Thiazolopyrimidinium systems with a quaternized nitrogen atom as promising anticancer agents
Thiazolopyrimidinium systems with a quaternized nitrogen atom are attracting increasing attention in the development of new anticancer drugs. Their unique chemical structure and potential biological properties make them promising candidates for the development of effective drugs. In recent years, re...
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| Format: | Article |
| Language: | Russian |
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Academician I.P. Pavlov First St. Petersburg State Medical University
2024-11-01
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| Series: | Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова |
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| Online Access: | https://www.sci-notes.ru/jour/article/view/1068 |
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| author | B. V. Paponov O. S. Shemchuk D. N. Maistrenko O. E. Molchanov V. V. Sharoyko K. N. Semenov |
| author_facet | B. V. Paponov O. S. Shemchuk D. N. Maistrenko O. E. Molchanov V. V. Sharoyko K. N. Semenov |
| author_sort | B. V. Paponov |
| collection | DOAJ |
| description | Thiazolopyrimidinium systems with a quaternized nitrogen atom are attracting increasing attention in the development of new anticancer drugs. Their unique chemical structure and potential biological properties make them promising candidates for the development of effective drugs. In recent years, researches have shown that these compounds have significant activity against various types of tumors due to their ability to interact with cellular targets, disrupting processes critical for the survival and proliferation of tumor cells. This review examines the current state of researches on thiazolopyrimidines, including synthesis, mechanisms of action, and evaluation of their antitumor potential, with an emphasis on the importance of the quaternized nitrogen atom in their biological activity. |
| format | Article |
| id | doaj-art-ab36df80daf54fb984e234f98a4bd20e |
| institution | DOAJ |
| issn | 1607-4181 2541-8807 |
| language | Russian |
| publishDate | 2024-11-01 |
| publisher | Academician I.P. Pavlov First St. Petersburg State Medical University |
| record_format | Article |
| series | Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова |
| spelling | doaj-art-ab36df80daf54fb984e234f98a4bd20e2025-08-20T03:00:54ZrusAcademician I.P. Pavlov First St. Petersburg State Medical UniversityУчёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова1607-41812541-88072024-11-01312101810.24884/1607-4181-2024-31-2-10-18678Thiazolopyrimidinium systems with a quaternized nitrogen atom as promising anticancer agentsB. V. Paponov0O. S. Shemchuk1D. N. Maistrenko2O. E. Molchanov3V. V. Sharoyko4K. N. Semenov5Pavlov UniversityPavlov University; A.M. Granov Russian Research Centre for Radiology and Surgical TechnologiesA.M. Granov Russian Research Centre for Radiology and Surgical TechnologiesA.M. Granov Russian Research Centre for Radiology and Surgical TechnologiesPavlov University; A.M. Granov Russian Research Centre for Radiology and Surgical Technologies; St Petersburg UniversityPavlov University; A.M. Granov Russian Research Centre for Radiology and Surgical Technologies; St Petersburg UniversityThiazolopyrimidinium systems with a quaternized nitrogen atom are attracting increasing attention in the development of new anticancer drugs. Their unique chemical structure and potential biological properties make them promising candidates for the development of effective drugs. In recent years, researches have shown that these compounds have significant activity against various types of tumors due to their ability to interact with cellular targets, disrupting processes critical for the survival and proliferation of tumor cells. This review examines the current state of researches on thiazolopyrimidines, including synthesis, mechanisms of action, and evaluation of their antitumor potential, with an emphasis on the importance of the quaternized nitrogen atom in their biological activity.https://www.sci-notes.ru/jour/article/view/1068quinolinequaternized atomtopoisomerasecytostaticsliposomes |
| spellingShingle | B. V. Paponov O. S. Shemchuk D. N. Maistrenko O. E. Molchanov V. V. Sharoyko K. N. Semenov Thiazolopyrimidinium systems with a quaternized nitrogen atom as promising anticancer agents Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова quinoline quaternized atom topoisomerase cytostatics liposomes |
| title | Thiazolopyrimidinium systems with a quaternized nitrogen atom as promising anticancer agents |
| title_full | Thiazolopyrimidinium systems with a quaternized nitrogen atom as promising anticancer agents |
| title_fullStr | Thiazolopyrimidinium systems with a quaternized nitrogen atom as promising anticancer agents |
| title_full_unstemmed | Thiazolopyrimidinium systems with a quaternized nitrogen atom as promising anticancer agents |
| title_short | Thiazolopyrimidinium systems with a quaternized nitrogen atom as promising anticancer agents |
| title_sort | thiazolopyrimidinium systems with a quaternized nitrogen atom as promising anticancer agents |
| topic | quinoline quaternized atom topoisomerase cytostatics liposomes |
| url | https://www.sci-notes.ru/jour/article/view/1068 |
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