Choroid plexus enlargement contributes to motor severity via regional glymphatic dysfunction in Parkinson’s disease
Abstract Choroid plexus (CP) enlargement and glymphatic dysfunction have been implicated in neurodegeneration, but their roles in Parkinson’s disease (PD) remain unclear. This retrospective cross-sectional study examined associations among CP volume, perivascular spaces (PVS), and motor symptom seve...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-05-01
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| Series: | npj Parkinson's Disease |
| Online Access: | https://doi.org/10.1038/s41531-025-00971-8 |
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| _version_ | 1849731880364015616 |
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| author | Linyu Liu Qiang Weng Qing Cai Xintong Yu Weibin Huang Shaohua Xie Yan Shi Huiting Li Yuxuan Zhang Jianping Hu Mengcheng Li Guannan Chen Ning Wang Xiang Lin Ying Fu Yu Lin |
| author_facet | Linyu Liu Qiang Weng Qing Cai Xintong Yu Weibin Huang Shaohua Xie Yan Shi Huiting Li Yuxuan Zhang Jianping Hu Mengcheng Li Guannan Chen Ning Wang Xiang Lin Ying Fu Yu Lin |
| author_sort | Linyu Liu |
| collection | DOAJ |
| description | Abstract Choroid plexus (CP) enlargement and glymphatic dysfunction have been implicated in neurodegeneration, but their roles in Parkinson’s disease (PD) remain unclear. This retrospective cross-sectional study examined associations among CP volume, perivascular spaces (PVS), and motor symptom severity in 123 PD patients stratified by disease stage. MRI quantified CP volume and PVS, including dilated PVS (dPVS), across brain regions. CP-dPVS correlations were stronger in early-stage PD. Region-specific analyses revealed CP volume was associated with PVS in the midbrain and basal ganglia. CP-dPVS correlations emerged in midbrain, basal ganglia, and centrum semiovale. Correlation matrix and mediation analyses together confirmed that only basal ganglia dPVS was both significantly correlated with motor symptoms and served as a mediator, accounting for 30.52% of the association between CP volume and motor severity. These findings suggest that CP enlargement contributes to motor severity in PD, in part through regional glymphatic dysfunction localized to the basal ganglia. |
| format | Article |
| id | doaj-art-ab34a9d86a7e412cab747c020d3b7af2 |
| institution | DOAJ |
| issn | 2373-8057 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Parkinson's Disease |
| spelling | doaj-art-ab34a9d86a7e412cab747c020d3b7af22025-08-20T03:08:24ZengNature Portfolionpj Parkinson's Disease2373-80572025-05-011111910.1038/s41531-025-00971-8Choroid plexus enlargement contributes to motor severity via regional glymphatic dysfunction in Parkinson’s diseaseLinyu Liu0Qiang Weng1Qing Cai2Xintong Yu3Weibin Huang4Shaohua Xie5Yan Shi6Huiting Li7Yuxuan Zhang8Jianping Hu9Mengcheng Li10Guannan Chen11Ning Wang12Xiang Lin13Ying Fu14Yu Lin15Department of Neurology, First Affiliated Hospital, Fujian Medical UniversityDepartment of Radiology of First Affiliated Hospital, Fujian Medical UniversityDepartment of Neurology, First Affiliated Hospital, Fujian Medical UniversityDepartment of Neurology, First Affiliated Hospital, Fujian Medical UniversityDepartment of Neurology, First Affiliated Hospital, Fujian Medical UniversityDepartment of Molecular Medicine and Surgery, Karolinska InstitutetDepartment of Neurology, First Affiliated Hospital, Fujian Medical UniversityDepartment of Neurology, First Affiliated Hospital, Fujian Medical UniversityDepartment of Neurology, First Affiliated Hospital, Fujian Medical UniversityDepartment of Radiology of First Affiliated Hospital, Fujian Medical UniversityDepartment of Radiology of First Affiliated Hospital, Fujian Medical UniversityKey Laboratory of OptoElectronic Science and Technology for Medicine of Ministry of Education, Fujian Provincial Key Laboratory of Photonics Technology, Fujian Normal UniversityDepartment of Neurology, First Affiliated Hospital, Fujian Medical UniversityDepartment of Neurology, First Affiliated Hospital, Fujian Medical UniversityDepartment of Neurology, First Affiliated Hospital, Fujian Medical UniversityDepartment of Neurology, First Affiliated Hospital, Fujian Medical UniversityAbstract Choroid plexus (CP) enlargement and glymphatic dysfunction have been implicated in neurodegeneration, but their roles in Parkinson’s disease (PD) remain unclear. This retrospective cross-sectional study examined associations among CP volume, perivascular spaces (PVS), and motor symptom severity in 123 PD patients stratified by disease stage. MRI quantified CP volume and PVS, including dilated PVS (dPVS), across brain regions. CP-dPVS correlations were stronger in early-stage PD. Region-specific analyses revealed CP volume was associated with PVS in the midbrain and basal ganglia. CP-dPVS correlations emerged in midbrain, basal ganglia, and centrum semiovale. Correlation matrix and mediation analyses together confirmed that only basal ganglia dPVS was both significantly correlated with motor symptoms and served as a mediator, accounting for 30.52% of the association between CP volume and motor severity. These findings suggest that CP enlargement contributes to motor severity in PD, in part through regional glymphatic dysfunction localized to the basal ganglia.https://doi.org/10.1038/s41531-025-00971-8 |
| spellingShingle | Linyu Liu Qiang Weng Qing Cai Xintong Yu Weibin Huang Shaohua Xie Yan Shi Huiting Li Yuxuan Zhang Jianping Hu Mengcheng Li Guannan Chen Ning Wang Xiang Lin Ying Fu Yu Lin Choroid plexus enlargement contributes to motor severity via regional glymphatic dysfunction in Parkinson’s disease npj Parkinson's Disease |
| title | Choroid plexus enlargement contributes to motor severity via regional glymphatic dysfunction in Parkinson’s disease |
| title_full | Choroid plexus enlargement contributes to motor severity via regional glymphatic dysfunction in Parkinson’s disease |
| title_fullStr | Choroid plexus enlargement contributes to motor severity via regional glymphatic dysfunction in Parkinson’s disease |
| title_full_unstemmed | Choroid plexus enlargement contributes to motor severity via regional glymphatic dysfunction in Parkinson’s disease |
| title_short | Choroid plexus enlargement contributes to motor severity via regional glymphatic dysfunction in Parkinson’s disease |
| title_sort | choroid plexus enlargement contributes to motor severity via regional glymphatic dysfunction in parkinson s disease |
| url | https://doi.org/10.1038/s41531-025-00971-8 |
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