Spectralis Optical Coherence Tomography for Evaluating Ocular Hypertensive and Glaucoma Suspect Eyes: Real-World Data from Taiwan
<b>Objectives</b>: The aim of this research was to evaluate the diagnostic performance of Spectralis optical coherence tomography (OCT) parameters for ocular hypertensive (OH) and glaucoma suspect (GS) eyes in an Asian population from Taiwan. <b>Methods</b>: This retrospectiv...
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MDPI AG
2025-05-01
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| author | Man-Sze Wong Chao-Wei Wu Yue-Cune Chang Hsin-Yi Chen |
| author_facet | Man-Sze Wong Chao-Wei Wu Yue-Cune Chang Hsin-Yi Chen |
| author_sort | Man-Sze Wong |
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| description | <b>Objectives</b>: The aim of this research was to evaluate the diagnostic performance of Spectralis optical coherence tomography (OCT) parameters for ocular hypertensive (OH) and glaucoma suspect (GS) eyes in an Asian population from Taiwan. <b>Methods</b>: This retrospective cross-sectional study included 258 OH (mean deviation [MD]: −1.10 ± 1.75 dB), 380 GS (MD: −1.24 ± 2.63 dB), and 742 normal (MD: −1.47 ± 3.29 dB) eyes. The diagnostic performance of Spectralis OCT parameters, including optic nerve head (ONH) and macular parameters, was compared among groups. The area under the receiver operating characteristic curve (AUC) of each parameter signified its power to differentiate between normal and OH or GS eyes. <b>Results</b>: In various scanning protocols, circumpapillary retinal nerve fiber layer (NFL)-temporal (AUC = 0.538), macular NFL-outer temporal (AUC = 0.611), and retinal average thickness (RAT)_1.8 (AUC = 0.578) were the best parameters in distinguishing OH eyes from normal eyes. Moreover, minimum rim width (MRW)-mean global (AUC = 0.737), macular NFL-outer temporal (AUC = 0.558), and RAT_2.8 (AUC = 0.543) were the best parameters in distinguishing GS eyes from normal eyes. After adjusting for age and refraction effects, we determined that the AUCs for OH and GS were 0.694 and 0.646, respectively. <b>Conclusions</b>: Our real-world data indicate that Spectralis OCT parameters show some potential for early glaucoma detection and monitoring, but their current diagnostic effectiveness remains limited. When managing OH eyes, caution is required in evaluating macular retinal NFL thickness in addition to the ONH. Bruch’s membrane opening–MRW is a potential objective indicator of ONH changes in GS eyes. |
| format | Article |
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| institution | DOAJ |
| issn | 2075-4418 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | MDPI AG |
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| series | Diagnostics |
| spelling | doaj-art-ab33c4be11ea4e85b4ba39d7dede577c2025-08-20T03:14:31ZengMDPI AGDiagnostics2075-44182025-05-011510125610.3390/diagnostics15101256Spectralis Optical Coherence Tomography for Evaluating Ocular Hypertensive and Glaucoma Suspect Eyes: Real-World Data from TaiwanMan-Sze Wong0Chao-Wei Wu1Yue-Cune Chang2Hsin-Yi Chen3School of Medicine, College of Medicine, Fu Jen Catholic University, New Taipei City 242062, TaiwanOphthalmology, Cishan Hospital, Ministry of Health and Welfare, Kaohsiung City 84247, TaiwanDepartment of Mathematics, Tamkang University, New Taipei City 25137, TaiwanSchool of Medicine, College of Medicine, Fu Jen Catholic University, New Taipei City 242062, Taiwan<b>Objectives</b>: The aim of this research was to evaluate the diagnostic performance of Spectralis optical coherence tomography (OCT) parameters for ocular hypertensive (OH) and glaucoma suspect (GS) eyes in an Asian population from Taiwan. <b>Methods</b>: This retrospective cross-sectional study included 258 OH (mean deviation [MD]: −1.10 ± 1.75 dB), 380 GS (MD: −1.24 ± 2.63 dB), and 742 normal (MD: −1.47 ± 3.29 dB) eyes. The diagnostic performance of Spectralis OCT parameters, including optic nerve head (ONH) and macular parameters, was compared among groups. The area under the receiver operating characteristic curve (AUC) of each parameter signified its power to differentiate between normal and OH or GS eyes. <b>Results</b>: In various scanning protocols, circumpapillary retinal nerve fiber layer (NFL)-temporal (AUC = 0.538), macular NFL-outer temporal (AUC = 0.611), and retinal average thickness (RAT)_1.8 (AUC = 0.578) were the best parameters in distinguishing OH eyes from normal eyes. Moreover, minimum rim width (MRW)-mean global (AUC = 0.737), macular NFL-outer temporal (AUC = 0.558), and RAT_2.8 (AUC = 0.543) were the best parameters in distinguishing GS eyes from normal eyes. After adjusting for age and refraction effects, we determined that the AUCs for OH and GS were 0.694 and 0.646, respectively. <b>Conclusions</b>: Our real-world data indicate that Spectralis OCT parameters show some potential for early glaucoma detection and monitoring, but their current diagnostic effectiveness remains limited. When managing OH eyes, caution is required in evaluating macular retinal NFL thickness in addition to the ONH. Bruch’s membrane opening–MRW is a potential objective indicator of ONH changes in GS eyes.https://www.mdpi.com/2075-4418/15/10/1256optical coherence tomographyocular hypertensiveglaucoma suspectTaiwan |
| spellingShingle | Man-Sze Wong Chao-Wei Wu Yue-Cune Chang Hsin-Yi Chen Spectralis Optical Coherence Tomography for Evaluating Ocular Hypertensive and Glaucoma Suspect Eyes: Real-World Data from Taiwan Diagnostics optical coherence tomography ocular hypertensive glaucoma suspect Taiwan |
| title | Spectralis Optical Coherence Tomography for Evaluating Ocular Hypertensive and Glaucoma Suspect Eyes: Real-World Data from Taiwan |
| title_full | Spectralis Optical Coherence Tomography for Evaluating Ocular Hypertensive and Glaucoma Suspect Eyes: Real-World Data from Taiwan |
| title_fullStr | Spectralis Optical Coherence Tomography for Evaluating Ocular Hypertensive and Glaucoma Suspect Eyes: Real-World Data from Taiwan |
| title_full_unstemmed | Spectralis Optical Coherence Tomography for Evaluating Ocular Hypertensive and Glaucoma Suspect Eyes: Real-World Data from Taiwan |
| title_short | Spectralis Optical Coherence Tomography for Evaluating Ocular Hypertensive and Glaucoma Suspect Eyes: Real-World Data from Taiwan |
| title_sort | spectralis optical coherence tomography for evaluating ocular hypertensive and glaucoma suspect eyes real world data from taiwan |
| topic | optical coherence tomography ocular hypertensive glaucoma suspect Taiwan |
| url | https://www.mdpi.com/2075-4418/15/10/1256 |
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